Guardians Secure Series Win Over Orioles 4-2
Thursday, April 16, 2026, 6:10 PM ET · Progressive Field
Cleveland Guardians 4, Baltimore Orioles 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won Baltimore Orioles vs Cleveland Guardians?
Cleveland Guardians beat Baltimore Orioles 4-2 at Progressive Field on April 16, 2026.
Who was favored in Baltimore Orioles vs Cleveland Guardians?
Cleveland Guardians were the favorite at DraftKings, moneyline -136 (about 58% implied). The favorite won.
The Cleveland Guardians clinched the series against the Baltimore Orioles with a 4-2 victory at Progressive Field, marking a successful conclusion to their four-game matchup, which they won 3-1 overall. This win is particularly significant as it comes after a challenging stretch for the Guardians, who had lost their last two games prior to this contest.
In the recent form leading up to the game, the Guardians had a record of 4-6 over their last ten games, with an average of 4.3 runs scored and 4.6 runs allowed per game. Their last five games showed a slightly improved scoring average of 4.8 runs but also highlighted defensive struggles, allowing an average of 5.4 runs. In their previous outings, they faced the St. Louis Cardinals, losing two close games before this victory, which was crucial for regaining some momentum.
On the other hand, the Orioles had a better record of 6-4 in their last ten games, though they were also on a two-game losing streak heading into this match. They averaged 4.5 runs scored and 4.3 runs allowed during this stretch. Their recent games included a series against the Arizona Diamondbacks, where they lost two consecutive games, which may have contributed to their struggles in this matchup.
The Guardians played this game at home, where they had a record of 11-9 for the season. Their performance at Progressive Field has been relatively balanced, with a home record of 2-2 in their last five games. Conversely, the Orioles, with a season record of 9-10, had a mixed away record of 3-1 over their last four games, showcasing their ability to compete on the road.
In terms of head-to-head matchups, the Guardians have had the upper hand recently, winning four of the last seven encounters against the Orioles. Their previous meetings included a series in July 2025, where the Guardians won three out of four games, indicating a competitive rivalry.
Injury concerns affected both teams, with the Guardians missing key players such as Slade Cecconi (arm), Rhys Hoskins (back), and Shawn Armstrong (calf), which could have an impact on their depth and performance. The Orioles were also dealing with injuries, including Tyler O'Neill (shoulder), Felix Bautista (shoulder), Christian Franklin (hand), Ryan Helsley (elbow), and Ryan Mountcastle (oblique), which limited their options.
The betting market, as provided by DraftKings, had the Guardians favored at -136 on the money line, with a spread of -1.5 and a total set at 8.0 runs. The odds indicated a slight preference for the Guardians to win, reflecting their home advantage and recent performance.
The game's scoring plays were highlighted by José Ramírez, who opened the scoring with a two-run homer in the first inning, followed by contributions from Steven Kwan and Brayan Valera, who added runs in the fifth and sixth innings, respectively. The Orioles managed to score late in the game, with a sacrifice fly from Gunnar Henderson and a double from Pete Alonso, but it was not enough to overcome the Guardians' lead.
Overall, this match showcased the Guardians' ability to bounce back after recent setbacks, while the Orioles will need to address their recent struggles to remain competitive as the season progresses.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | CLE -136 | 8 o -102 / u -118 | Baltimore Orioles +113 · Cleveland Guardians -136 |
Injury report
- Slade Cecconi15-Day-ILArmCleveland Guardians
- Rhys Hoskins10-Day-ILBackCleveland Guardians
- Shawn Armstrong60-Day-ILCalfCleveland Guardians
- Tyler O'Neill10-Day-ILShoulderBaltimore Orioles
- Felix Bautista60-Day-ILShoulderBaltimore Orioles
- Christian Franklin10-Day-ILHandBaltimore Orioles
- Ryan Helsley60-Day-ILElbowBaltimore Orioles
- Ryan Mountcastle60-Day-ILObliqueBaltimore Orioles
Recent form
Cleveland Guardians
Last 10: 4-6Streak L24.3 scored · 4.6 allowed per game2-2 at home
- L3-5at St. Louis CardinalsApr 15
- L5-6at St. Louis CardinalsApr 14
- W9-3at St. Louis CardinalsApr 13
- L1-13at Atlanta BravesApr 12
- W6-0at Atlanta BravesApr 11
- L5-11at Atlanta BravesApr 10
- W10-2vs Kansas City RoyalsApr 8
- W2-1vs Kansas City RoyalsApr 7
- L2-4vs Kansas City RoyalsApr 6
- L0-1vs Chicago CubsApr 5
Baltimore Orioles
Last 10: 6-4Streak L24.5 scored · 4.3 allowed per game3-1 away
- L5-8vs Arizona DiamondbacksApr 15
- L3-4vs Arizona DiamondbacksApr 14
- W9-7vs Arizona DiamondbacksApr 13
- W6-2vs San Francisco GiantsApr 12
- W6-2vs San Francisco GiantsApr 11
- L3-6vs San Francisco GiantsApr 10
- W5-3at Chicago White SoxApr 8
- W4-2at Chicago White SoxApr 7
- W2-1at Chicago White SoxApr 6
- L2-8at Pittsburgh PiratesApr 5
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Tampa Bay | - | 56 | L1 | .597 | 83 |
| New York | 3.5 | 60 | W2 | .571 | 80 |
| Boston | 8.5 | 65 | L2 | .536 | 75 |
| Toronto | 14.5 | 71 | W1 | .493 | 69 |
| Baltimore | 14.5 | 71 | L2 | .493 | 69 |
| Chicago | - | 66 | L1 | .525 | 73 |
| Cleveland | 3 | 69 | L1 | .504 | 70 |
| Minnesota | 6.5 | 73 | L1 | .479 | 67 |
| Detroit | 9 | 75 | W1 | .460 | 64 |
| Kansas City | 11.5 | 78 | L3 | .443 | 62 |
How the scoring went
- 1st Inning0-2Ramírez homered to right center (388 feet), DeLauter scored.
- 5th Inning0-3Kwan singled to right, Rocchio scored.
- 6th Inning0-4Valera singled to left, Ramírez scored, Manzardo to second.
- 9th Inning1-4Henderson hit sacrifice fly to right, Taveras scored, Alexander to third.
- 9th Inning2-4Alonso doubled to right, Alexander scored, Ward to third.
Win probability
Above the line favours Cleveland Guardians, below favours Baltimore Orioles.
Venue
- Progressive FieldCleveland, Ohio
- Attendance14748
- OfficialsCarlos Torres, Nate Tomlinson, Mark Wegner, Bruce Dreckman
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These two, other days
- Orioles Secure Series Win Over Guardians with 9-5 VictorySep 9, 2026
- Guardians Defeat Orioles 9-5 in Camden Yards ShowdownSep 8, 2026
- Orioles Defeat Guardians 6-4 in Exciting MatchupSep 7, 2026
- Guardians Secure Series Win Over Orioles 8-4Apr 19, 2026
- Guardians Secure Series Win Against OriolesApr 18, 2026