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MLB · Final

Cardinals Edge Cubs in Thrilling 6-5 Victory

Friday, May 29, 2026, 7:15 PM ET · Busch Stadium

St. Louis Cardinals 6, Chicago Cubs 5, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Chicago Cubs vs St. Louis Cardinals?

St. Louis Cardinals beat Chicago Cubs 6-5 at Busch Stadium on May 29, 2026.

Who was favored in Chicago Cubs vs St. Louis Cardinals?

Chicago Cubs were the favorite at DraftKings, moneyline -135 (about 57% implied). The underdog won.

In a tightly contested game at Busch Stadium, the St. Louis Cardinals triumphed over the Chicago Cubs with a final score of 6-5, clinching the series 2-1. This matchup was particularly noteworthy as both teams have been struggling to find their footing in the league, making every victory crucial. The Cardinals improved their home record to 31-25 while the Cubs fell to 31-28 on the road.

The recent form of both teams highlighted their challenges leading up to this game. The Cardinals entered with a record of 2-6-2 over their last ten games, currently on a three-game losing streak, averaging just 2.1 runs scored and 3.5 runs allowed per game. Their last few outings included losses to the Milwaukee Brewers, where they scored only one run in two games and were shut out in another. Conversely, the Cubs had a record of 2-8 in their last ten games but were riding a two-game winning streak, scoring an average of 3.1 runs while allowing 5.4 runs per game. Their recent victories against the Pittsburgh Pirates, where they scored 7 and 10 runs respectively, showcased their offensive potential.

When considering home versus away performance, the Cardinals have struggled at home with a record of 1-3 in their last five games, while the Cubs have been inconsistent, with a 0-6 record in their last six away games. This game was crucial for both teams to build momentum and confidence as they navigate the remainder of the season.

Historically, the Cardinals and Cubs have faced each other frequently, with the Cardinals holding a slight edge in their recent meetings, winning 5 of the last 12 matchups. In their previous encounters in 2025, the Cubs had the upper hand, winning three consecutive games against the Cardinals before this series.

In terms of injuries, the Cardinals were notably affected, with several players on the injured list, including Everson Pereira and Masyn Winn, both on the 10-Day IL. Ramon Urias was listed as day-to-day with an arm issue, while Andre Pallante and JJ Wetherholt were also sidelined. The Cubs had their own injury concerns, with Edward Cabrera on the 15-Day IL and Shelby Miller on the 60-Day IL. Jacob Webb and Pedro Ramirez were day-to-day, adding to the uncertainty surrounding their lineup.

The betting market, as provided by DraftKings, favored the Cubs with odds of -135, while the Cardinals were at +112. The spread was set at 1.5, with a total of 7.5 runs for the game, indicating expectations for a competitive matchup.

The conditions at Busch Stadium were typical for a late spring evening, which can often influence player performance. Fans expected an exciting game, and the players delivered with several key moments. The scoring began in the first inning when Ian Happ homered to right center, bringing in two runs for the Cubs. However, the Cardinals quickly responded with a home run from Velázquez, tying the game at 3-3.

As the game progressed, the Cardinals took the lead with a single from Busch in the second inning, but the Cubs fought back to tie it again in the fourth inning with a homer from Saggese. The game remained tight, with Herrera's fifth-inning homer giving the Cardinals a narrow lead. In the eighth inning, Fermín's single extended the Cardinals' lead to 6-4, but the Cubs managed to score one more run in the ninth, making it a nail-biting finish.

Ultimately, the Cardinals held on to secure the win, a much-needed boost for a team struggling with injuries and recent form. Fans left Busch Stadium buzzing from the excitement of a close game, while the Cubs will look to regroup as they continue their season.

Odds

BookSpreadTotalMoneyline
DraftKingsCHC -135 7.5 o -118 / u -102 Chicago Cubs -135 · St. Louis Cardinals +112

What these prices pay on $100 · What these numbers mean

Injury report

  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Ramon UriasDay-To-DayArmSt. Louis Cardinals
  • Masyn Winn10-Day-ILThumbSt. Louis Cardinals
  • Andre Pallante15-Day-ILElbowSt. Louis Cardinals
  • JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
  • Edward Cabrera15-Day-ILFingerChicago Cubs
  • Shelby Miller60-Day-ILElbowChicago Cubs
  • Jacob WebbDay-To-DayArmChicago Cubs
  • Pedro RamirezDay-To-DayBackChicago Cubs
  • Gavin Hollowell15-Day-ILShoulderChicago Cubs

Recent form

St. Louis Cardinals

Last 10: 2-6-2Streak L32.1 scored · 3.5 allowed per game1-3 at home

  • L1-2at Milwaukee BrewersMay 27
  • L0-6at Milwaukee BrewersMay 26
  • L1-5at Milwaukee BrewersMay 25
  • D0-0at Cincinnati RedsMay 24
  • W8-1at Cincinnati RedsMay 23
  • D0-0at Cincinnati RedsMay 22
  • L2-6vs Pittsburgh PiratesMay 21
  • L0-7vs Pittsburgh PiratesMay 20
  • W9-6vs Pittsburgh PiratesMay 19
  • L0-2vs Kansas City RoyalsMay 17

Chicago Cubs

Last 10: 2-8Streak W23.1 scored · 5.4 allowed per game2-2 away

  • W7-2at Pittsburgh PiratesMay 28
  • W10-4at Pittsburgh PiratesMay 27
  • L1-12at Pittsburgh PiratesMay 26
  • L1-2at Pittsburgh PiratesMay 25
  • L5-8vs Houston AstrosMay 24
  • L0-3vs Houston AstrosMay 23
  • L2-4vs Houston AstrosMay 22
  • L0-5vs Milwaukee BrewersMay 20
  • L2-5vs Milwaukee BrewersMay 19
  • L3-9vs Milwaukee BrewersMay 18

Standings

TeamGames behindLostStreakWin %Won
Milwaukee-53W2.62187
Chicago962L2.55778
St. Louis1770W2.50070
Pittsburgh1972L1.48668
Cincinnati2073W2.47967

How the scoring went

  1. 1st Inning3-0Happ homered to right center (407 feet), Busch scored and Bregman scored.
  2. 1st Inning3-3Velázquez homered to left center (411 feet), Herrera scored and Walker scored.
  3. 2nd Inning4-3Busch singled to left, Swanson scored, Hoerner to second.
  4. 4th Inning4-4Saggese homered to left center (402 feet).
  5. 5th Inning4-5Herrera homered to left center (409 feet).
  6. 8th Inning4-6Fermín singled to left, Velázquez scored, Winn to second.
  7. 9th Inning5-6Busch grounded out to third, Crow-Armstrong scored.

Win probability

Above the line favours St. Louis Cardinals, below favours Chicago Cubs.

Venue

  • Busch StadiumSt. Louis, Missouri
  • Attendance37564
  • OfficialsPaul Clemons, Edwin Jimenez, Quinn Wolcott, Ramon De Jesus

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.