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MLB · Final

Guardians Secure Series Win Over White Sox

Wednesday, September 16, 2026, 1:00 PM ET · Progressive Field

Quick answers

Who won Chicago White Sox vs Cleveland Guardians?

Cleveland Guardians beat Chicago White Sox 6-3 at Progressive Field on September 16, 2026.

Who was favored in Chicago White Sox vs Cleveland Guardians?

Cleveland Guardians were the favorite at DraftKings, moneyline -166 (about 62% implied). The favorite won.

The Cleveland Guardians triumphed over the Chicago White Sox with a final score of 6-3 at Progressive Field, clinching the series 2-1. This victory was significant for the Guardians, who improved their record to 78-75, while the White Sox fell to 77-75. The match showcased a competitive spirit, particularly as both teams are closely matched in the standings, making this series a vital one for playoff positioning.

Cleveland's recent form has been strong, finishing their last ten games with a record of 6-4 and currently on a one-game winning streak. They have averaged 5.2 runs scored per game while allowing 5.1 runs during this stretch. In their last five games, the Guardians have maintained a record of 3-2, scoring an average of 5.8 runs while allowing 5.2. The White Sox, conversely, have struggled recently, posting a record of 3-7 in their last ten games and currently on a one-game losing streak. They have averaged 4.0 runs scored and 4.3 runs allowed in that same span. Their last five games reflect a particularly concerning trend, with a record of 1-4 and an average of just 3.4 runs scored.

At home, the Guardians have a record of 3-2 in their last five games, while the White Sox have struggled more on the road, with a 1-3 record in their last away games. The matchup highlighted the Guardians' home advantage, as they have generally performed better at Progressive Field compared to the White Sox's away performances.

In terms of head-to-head meetings, the Guardians have had the upper hand recently, with a record of 15 wins, 9 losses, and 1 tie against the White Sox. This series included a thrilling 7-6 win for the Guardians just a day prior, further emphasizing their competitive edge in recent encounters.

Injury concerns also played a role in the matchup. The Guardians had several players listed as day-to-day, including Angel Martinez and Chase DeLauter, while Colin Holderman and Rhys Hoskins were on the injured list. The White Sox faced their own challenges, with Huascar Brazoban and Tanner Murray on the injured list, and Colson Montgomery listed as day-to-day.

Betting lines from DraftKings indicated the Guardians were favored at -166, with a spread of -1.5 and a total set at 7.0. The odds reflected the Guardians' recent form and home advantage, while the White Sox were listed at +137 on the money line.

The game conditions were conducive to a competitive matchup, with both teams eager to secure a win. Key moments included a strong performance from the Guardians in the third inning, where Adell's single brought in two runs. The White Sox responded in the fifth with Pham's impressive homer, but the Guardians regained control in the sixth with Halpin's homer and Ramírez's double, ultimately sealing their victory.

Fans and viewers should have noted the Guardians' ability to capitalize on scoring opportunities, as evidenced by their scoring plays throughout the game. The Guardians' offense demonstrated resilience, particularly in high-pressure moments, which will be crucial as they move forward in the season.

What we said beforehand

The Cleveland Guardians and Chicago White Sox are set to clash at Progressive Field on September 16, 2026, with the series currently tied at one game apiece. Both teams enter this matchup with nearly identical records, the Guardians at 77-75 and the White Sox at 77-74, making this contest significant as they vie for playoff positioning.

In their recent form, the Guardians have shown a slight edge, winning four of their last five games. Their most recent results include a victory against the Minnesota Twins (5-2), a loss to the Twins (4-3), and a win against the White Sox (7-6) on September 15. Over their last ten games, the Guardians have a record of 6-4, averaging 5.2 runs scored while allowing 5.1 runs per game. In contrast, the White Sox have struggled, managing only three wins in their last ten games, with a record of 3-7. Their recent outings include a loss to the Guardians (7-6) and a victory against them (7-3) on September 14. The White Sox have averaged 4.0 runs scored and allowed 4.3 runs during this stretch.

Home-field advantage may play a role in this matchup, as the Guardians have a home record of 3-2 in their last five games, averaging 5.8 runs scored and 5.2 runs allowed. The White Sox, meanwhile, have struggled on the road, with a 1-3 record in their last four away games, scoring an average of 3.4 runs while allowing 4.4 runs.

Historically, the Guardians have had the upper hand in their recent meetings, holding a 15-9-1 record against the White Sox over the last two seasons. Their last five encounters have seen the Guardians win two games and lose three, including the latest contest where they edged the White Sox 7-6.

In terms of injuries, the Guardians are dealing with several key players who are either day-to-day or on the injured list. Angel Martinez and Chase DeLauter are both listed as day-to-day, while Colin Holderman is on the 15-day injured list, Rhys Hoskins is on the 10-day injured list, and Shawn Armstrong is on the 60-day injured list. The White Sox also have notable absences, with Huascar Brazoban on the 15-day injured list, Tanner Murray on the 60-day injured list, Joey Bart on the 10-day injured list, and both Prelander Berroa and Ky Bush on the 60-day injured list.

The betting market reflects the competitive nature of this matchup, with DraftKings listing the Guardians as favorites at -156 on the moneyline, while the White Sox are priced at +129. The spread is set at -1.5 for the Guardians, with a total of 7.0 runs for the game.

Weather conditions for the game are expected to be warm, with a temperature of 78°F and a 48% chance of precipitation. Wind gusts are forecasted at 8 mph, which could influence gameplay.

As the Guardians and White Sox face off, viewers should watch for the performance of key players, including Chase DeLauter, who leads the Guardians with a batting average of .289, and Miguel Vargas of the White Sox, who has hit 31 home runs and driven in 84 runs. With both teams fighting for a crucial win, this matchup promises to be an exciting contest.

Odds

BookSpreadTotalMoneyline
DraftKingsCLE -166 7 o +101 / u -122 Chicago White Sox +137 · Cleveland Guardians -166

What these prices pay on $100 · What these numbers mean

Injury report

  • Angel MartinezDay-To-DaySideCleveland Guardians
  • Chase DeLauterDay-To-DayWristCleveland Guardians
  • Colin Holderman15-Day-ILWristCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians
  • Huascar Brazoban15-Day-ILLatChicago White Sox
  • Tanner Murray60-Day-ILShoulderChicago White Sox
  • Colson MontgomeryDay-To-DayWristChicago White Sox
  • Joey Bart10-Day-ILHandChicago White Sox
  • Prelander Berroa60-Day-ILElbowChicago White Sox

Recent form

Cleveland Guardians

Last 10: 6-4Streak W15.2 scored · 5.1 allowed per game3-2 at home

  • W7-6vs Chicago White SoxSep 15
  • L3-7vs Chicago White SoxSep 14
  • W9-2at Minnesota TwinsSep 13
  • W5-2at Minnesota TwinsSep 12
  • L5-9at Baltimore OriolesSep 9
  • W9-5at Baltimore OriolesSep 8
  • L4-6at Baltimore OriolesSep 7
  • W3-2vs Detroit TigersSep 6
  • L0-6vs Detroit TigersSep 5
  • W7-6vs Detroit TigersSep 4

Chicago White Sox

Last 10: 3-7Streak L14 scored · 4.3 allowed per game1-3 away

  • L6-7at Cleveland GuardiansSep 15
  • W7-3at Cleveland GuardiansSep 14
  • L1-3at St. Louis CardinalsSep 13
  • L3-7at St. Louis CardinalsSep 12
  • L0-2vs Pittsburgh PiratesSep 10
  • L2-4vs Pittsburgh PiratesSep 9
  • L3-9vs Pittsburgh PiratesSep 8
  • W10-1vs Minnesota TwinsSep 6
  • L4-6vs Minnesota TwinsSep 5
  • W4-1vs Minnesota TwinsSep 4

Standings

TeamGames behindLostStreakWin %Won
Cleveland-75W2.51078
Chicago0.575L2.50777
Detroit579W6.47772
Minnesota781L3.46470
Kansas City1185L3.43766

How the scoring went

  1. 3rd Inning0-2Adell singled to left, Halpin scored and Kwan scored.
  2. 5th Inning3-2Pham homered to left center (412 feet), Meidroth scored and Grichuk scored.
  3. 6th Inning3-5Halpin homered to right center (393 feet), Fry scored and Hedges scored.
  4. 6th Inning3-6Ramírez doubled to left, Rocchio scored, Kwan to third.

Win probability

Above the line favours Cleveland Guardians, below favours Chicago White Sox.

Venue

  • Progressive FieldCleveland, Ohio
  • Attendance23336
  • OfficialsEdwin Moscoso, Nic Lentz, John Bacon, David Rackley

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.