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MLB · Final

Guardians Edge Red Sox in Close Contest

Tuesday, September 22, 2026, 6:45 PM ET · Fenway Park

Quick answers

Who won Cleveland Guardians vs Boston Red Sox?

Cleveland Guardians beat Boston Red Sox 3-2 at Fenway Park on September 22, 2026.

Who was favored in Cleveland Guardians vs Boston Red Sox?

Boston Red Sox were the favorite at DraftKings, moneyline -123 (about 55% implied). The underdog won.

In a tightly contested matchup at Fenway Park, the Cleveland Guardians triumphed over the Boston Red Sox with a final score of 3-2, taking a 2-0 lead in their series. This victory is particularly notable as it extends the Guardians' winning streak to six games, showcasing their strong form as they push for a playoff spot.

The Red Sox entered the game with an overall record of 84-73, while the Guardians had a record of 82-75. Despite being at home, the Red Sox have struggled recently, going 4-6 in their last ten games and losing their last two. They averaged 3.0 runs scored and allowed 3.4 runs during this stretch. In contrast, the Guardians have been in excellent form, winning eight of their last ten games, with an impressive scoring average of 6.2 runs per game and allowing 4.3 runs.

At Fenway Park, the Red Sox have a home record of 2-2 in their last four games, while the Guardians have fared well on the road with a 3-1 record in their last four away games. The previous meetings between these two teams earlier in the season saw the Guardians win two out of three games, including a decisive 9-1 victory on May 30, 2026.

In terms of injuries, the Red Sox are dealing with several key players on the injured list, including Tanner Houck and Johan Oviedo, both on the 60-day IL due to elbow issues. Aroldis Chapman is listed as day-to-day with a lat injury, while Ceddanne Rafaela and Curtis Mead are on the 10-day IL with quadriceps and wrist injuries, respectively. The Guardians also have injury concerns, with Colin Holderman on the 15-day IL with a wrist injury, Rhys Hoskins on the 10-day IL with a back issue, and Shawn Armstrong on the 60-day IL due to a calf injury.

The market for this matchup, as provided by DraftKings, had the Red Sox as slight favorites with odds of -123, while the Guardians were at +102. The total for the game was set at 6.0, with the over at -115 and the under at -105. This indicates a close contest anticipated by the betting market.

The game began with the Guardians striking first in the second inning. Fry singled to center, bringing Martínez home, followed by a double play that allowed Fry to score, putting the Guardians ahead 2-0. The Red Sox responded in the same inning when Monasterio grounded out, scoring Rutschman, narrowing the gap to 2-1.

As the game progressed, the Red Sox managed to tie it in the eighth inning when Gasper hit a home run to right field, measuring 390 feet. However, the Guardians regained the lead in the ninth inning when Lowe hit a sacrifice fly, allowing DeLauter to score, making it 3-2.

With the final score settled, the Guardians' victory not only solidifies their recent form but also places them in a favorable position as they continue to vie for postseason contention. The Red Sox will need to regroup quickly as they look to bounce back in the next game of the series.

What we said beforehand

The Boston Red Sox will take on the Cleveland Guardians at Fenway Park on September 22, 2026, in a matchup that features two teams vying for postseason positioning. The Red Sox currently hold a 2-1 lead in their season series against the Guardians, which adds an extra layer of intrigue to this contest.

In recent form, the Red Sox have struggled, posting a record of 2-3 in their last five games. Their most recent results include two losses to the Tampa Bay Rays (5-1 and 2-1) and a win against them (4-2), as well as a split series with the Texas Rangers (losing 7-3 and winning 4-3). Over their last ten games, the Red Sox have a record of 4-6, averaging 3.0 runs scored per game while allowing 3.4 runs.

Conversely, the Guardians are on a hot streak, winning their last five games and boasting an impressive 8-2 record over their last ten. Their recent victories include a series sweep against the Athletics, winning 1-0, 12-6, and 5-3, as well as two wins against the Chicago White Sox (7-6 and 6-3). The Guardians have averaged 6.2 runs scored per game in their last ten outings, while allowing 4.3 runs.

At home, the Red Sox have a record of 2-2 in their last four games, while their away record stands at 2-4. The Guardians, on the other hand, have performed well on the road, with a 3-1 record in their last four away games.

In terms of injuries, the Red Sox will be without Tanner Houck and Johan Oviedo, both on the 60-day injured list due to elbow issues. Aroldis Chapman is listed as day-to-day with a lat injury, while Ceddanne Rafaela and Curtis Mead are on the 10-day injured list for quadriceps and wrist injuries, respectively. The Guardians will miss Colin Holderman (15-day IL, wrist), Rhys Hoskins (10-day IL, back), and Shawn Armstrong (60-day IL, calf).

The betting market, as reported by DraftKings, has the Red Sox favored at -126 on the money line, with a spread of -1.5 and a total set at 6.0 runs. The odds for the over are -115, while the under is priced at -105.

Weather conditions for the game are expected to be cool, with a temperature of 58°F and wind gusts reaching 23 mph, which could impact gameplay.

Viewers should watch for the performance of key players. For the Red Sox, Willson Contreras leads the team with 27 home runs and 81 RBIs, while Ceddanne Rafaela has a batting average of .282. The Guardians' Chase DeLauter boasts a .291 batting average, and Angel Martinez has contributed 17 home runs this season. This matchup promises to be a significant one as both teams look to solidify their playoff aspirations.

Odds

BookSpreadTotalMoneyline
DraftKingsBOS -123 6 o -115 / u -105 Cleveland Guardians +102 · Boston Red Sox -123

What these prices pay on $100 · What these numbers mean

Injury report

  • Tanner Houck60-Day-ILElbowBoston Red Sox
  • Aroldis ChapmanDay-To-DayLatBoston Red Sox
  • Johan Oviedo60-Day-ILElbowBoston Red Sox
  • Ceddanne Rafaela10-Day-ILQuadricepsBoston Red Sox
  • Curtis Mead10-Day-ILWristBoston Red Sox
  • Colin Holderman15-Day-ILWristCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians

Recent form

Boston Red Sox

Last 10: 4-6Streak L23 scored · 3.4 allowed per game2-2 at home

  • L1-5at Tampa Bay RaysSep 20
  • L1-2at Tampa Bay RaysSep 19
  • W4-2at Tampa Bay RaysSep 18
  • W4-3at Texas RangersSep 18
  • L3-7at Texas RangersSep 17
  • L2-4at Texas RangersSep 16
  • W4-1vs Kansas City RoyalsSep 13
  • W5-1vs Kansas City RoyalsSep 12
  • L2-3vs Kansas City RoyalsSep 11
  • L4-6vs Los Angeles AngelsSep 9

Cleveland Guardians

Last 10: 8-2Streak W56.2 scored · 4.3 allowed per game3-1 away

  • W1-0vs AthleticsSep 20
  • W12-6vs AthleticsSep 19
  • W5-3vs AthleticsSep 18
  • W6-3vs Chicago White SoxSep 16
  • W7-6vs Chicago White SoxSep 15
  • L3-7vs Chicago White SoxSep 14
  • W9-2at Minnesota TwinsSep 13
  • W5-2at Minnesota TwinsSep 12
  • L5-9at Baltimore OriolesSep 9
  • W9-5at Baltimore OriolesSep 8

Standings

TeamGames behindLostStreakWin %Won
Cleveland-75W6.52282
Chicago1.576W2.51380
Detroit8.584L1.46874
Minnesota984L1.46573
Kansas City14.589L4.42967
Tampa Bay-61L1.60995
New York566W1.57790
Boston11.573L3.53584
Toronto18.580L1.49077
Baltimore19.581W1.48476

How the scoring went

  1. 2nd Inning1-0Fry singled to center, Martínez scored.
  2. 2nd Inning2-0Rocchio grounded into double play, second to shortstop to first, Fry scored, Hedges out at second, Bazzana to third.
  3. 2nd Inning2-1Monasterio grounded out to shortstop, Rutschman scored.
  4. 8th Inning2-2Gasper homered to right (390 feet).
  5. 9th Inning3-2Lowe hit sacrifice fly to left, DeLauter scored.

Win probability

Above the line favours Boston Red Sox, below favours Cleveland Guardians.

Venue

  • Fenway ParkBoston, Massachusetts
  • Attendance37416
  • OfficialsRamon De Jesus, Paul Clemons, Quinn Wolcott, Adrian Johnson

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.