Astros Complete Sweep Over Cubs at Wrigley Field
Friday, May 22, 2026, 2:20 PM ET · Wrigley Field
Houston Astros 4, Chicago Cubs 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won Houston Astros vs Chicago Cubs?
Houston Astros beat Chicago Cubs 4-2 at Wrigley Field on May 22, 2026.
Who was favored in Houston Astros vs Chicago Cubs?
Chicago Cubs were the favorite at DraftKings, moneyline -148 (about 60% implied). The underdog won.
In a decisive game at Wrigley Field, the Houston Astros defeated the Chicago Cubs 4-2, completing a three-game series sweep. This victory highlights the Astros' recent dominance over the Cubs, having now won all three matchups in this series. The Cubs, currently struggling, have now lost their last five games and have a record of 2-8 over their last ten outings.
The Astros entered this game with a record of 21-31, while the Cubs held a slightly better record of 29-22. However, the recent form of both teams tells a different story. The Cubs have been on a downward spiral, with an average of 3.1 runs scored and 5.3 runs allowed in their last ten games. Their home record has been particularly poor, with a 0-3 record in their last three games at Wrigley Field. In contrast, the Astros have managed to score an average of 1.6 runs while allowing 4.3 runs in their last ten games, indicating their own struggles, but they managed to secure the win in this matchup.
In terms of scoring, the Astros took an early lead in the third inning when Christian Vázquez homered to left center, marking the first run of the game. The Astros continued to build their lead in the fourth inning with a series of plays that saw them score three more runs, including a fielder's choice that allowed Walker to score. By the fifth inning, the Astros had extended their lead to 4-0. It wasn't until the sixth inning that the Cubs managed to get on the scoreboard, with Pete Crow-Armstrong hitting a two-run homer, but it was not enough to overcome the deficit.
Injury concerns for the Cubs include Edward Cabrera and Shelby Miller, both on the injured list, while Jacob Webb and Pedro Ramirez are listed as day-to-day. The Astros are also dealing with injuries, including Brice Matthews and Carlos Correa, who are both on the 60-day injured list.
The betting odds from DraftKings reflected the Cubs as the favorites at -148, with a spread of -1.5 and a total set at 7.0 runs. The conditions at Wrigley Field were typical for a spring evening, but the Cubs could not capitalize on their home advantage.
This game serves as a reminder of the challenges the Cubs face as they navigate through a tough stretch, while the Astros look to build on their momentum from this series sweep.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | CHC -148 | 7 o +101 / u -121 | Houston Astros +123 · Chicago Cubs -148 |
Injury report
- Edward Cabrera15-Day-ILFingerChicago Cubs
- Shelby Miller60-Day-ILElbowChicago Cubs
- Jacob WebbDay-To-DayArmChicago Cubs
- Pedro RamirezDay-To-DayBackChicago Cubs
- Gavin Hollowell15-Day-ILShoulderChicago Cubs
- Brice Matthews60-Day-ILKneeHouston Astros
- Mike Burrows15-Day-ILElbowHouston Astros
- Carlos Correa60-Day-ILAnkleHouston Astros
- Brandon Walter60-Day-ILElbowHouston Astros
Recent form
Chicago Cubs
Last 10: 2-8Streak L53.1 scored · 5.3 allowed per game0-3 at home
- L0-5vs Milwaukee BrewersMay 20
- L2-5vs Milwaukee BrewersMay 19
- L3-9vs Milwaukee BrewersMay 18
- L8-9at Chicago White SoxMay 17
- L3-8at Chicago White SoxMay 16
- W10-5at Chicago White SoxMay 15
- W2-0at Atlanta BravesMay 14
- L1-4at Atlanta BravesMay 13
- L2-5at Atlanta BravesMay 12
- L0-3at Texas RangersMay 10
Houston Astros
Last 10: 3-7Streak L11.6 scored · 4.3 allowed per game1-4 away
- L1-4at Minnesota TwinsMay 20
- W2-1at Minnesota TwinsMay 19
- L3-6at Minnesota TwinsMay 18
- L0-8vs Texas RangersMay 17
- W2-0vs Texas RangersMay 16
- W4-3vs Seattle MarinersMay 14
- L2-10vs Seattle MarinersMay 13
- L1-3vs Seattle MarinersMay 12
- L0-5at Cincinnati RedsMay 10
- L1-3at Cincinnati RedsMay 9
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Houston | - | 69 | W1 | .507 | 71 |
| Texas | 2 | 71 | L1 | .493 | 69 |
| Seattle | 5 | 74 | W2 | .471 | 66 |
| Athletics | 17 | 86 | W1 | .386 | 54 |
| Los Angeles | 18 | 87 | L2 | .379 | 53 |
| Milwaukee | - | 53 | W2 | .621 | 87 |
| Chicago | 9 | 62 | L2 | .557 | 78 |
| St. Louis | 17 | 70 | W2 | .500 | 70 |
| Pittsburgh | 19 | 72 | L1 | .486 | 68 |
| Cincinnati | 20 | 73 | W2 | .479 | 67 |
How the scoring went
- 3rd Inning1-0Vázquez homered to left center (371 feet).
- 4th Inning2-0Cole grounded into fielder's choice to shortstop, Walker scored, Smith out at second, Shewmake to third.
- 4th Inning3-0Vázquez singled to right, Shewmake scored, Cole to third.
- 5th Inning4-0Matthews singled to center, Paredes scored, Meyers to second.
- 6th Inning4-2Crow-Armstrong homered to right (406 feet), Amaya scored.
Win probability
Above the line favours Chicago Cubs, below favours Houston Astros.
Venue
- Wrigley FieldChicago, Illinois
- Attendance37332
- OfficialsChad Fairchild, Chad Whitson, Bill Miller, Brian Walsh
Elsewhere
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These two, other days
- Astros Complete Sweep Over Cubs at Wrigley FieldMay 24, 2026
- Astros Sweep Cubs with 3-0 Series VictoryMay 23, 2026