Cardinals Secure Victory Over Brewers at Busch Stadium
Sunday, September 21, 2025, 2:15 PM ET · Busch Stadium
St. Louis Cardinals 5, Milwaukee Brewers 1, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won Milwaukee Brewers vs St. Louis Cardinals?
St. Louis Cardinals beat Milwaukee Brewers 5-1 at Busch Stadium on September 21, 2025.
In a decisive matchup, the St. Louis Cardinals triumphed over the Milwaukee Brewers with a final score of 5-1 at Busch Stadium. This victory marked the Cardinals' fourth win in their six-game series against the Brewers this season, showcasing their ability to compete against a team with a significantly better record. The Brewers entered this game with an impressive away record of 95-61, while the Cardinals held a record of 76-80.
The Cardinals have had a challenging stretch recently, going 3-7 in their last ten games. Despite this, they managed to snap a losing streak with this win, having lost their previous game against the Brewers just a day earlier. In their last five games, the Cardinals averaged 5.2 runs scored per game while allowing 5.4 runs, indicating a struggle on the mound despite some offensive capabilities. At home, they have performed slightly better, with a home record of 3-2 in their last five games.
Conversely, the Brewers had been in strong form leading up to this game, with a record of 7-3 in their last ten outings. Their scoring average was notably higher at 5.9 runs per game, while they allowed only 3.6 runs, reflecting their dominance in recent matchups. However, they faced a setback in this game, marking a loss that halted their momentum after a series of strong performances against teams like the Los Angeles Angels.
The game unfolded with the Cardinals taking an early lead in the third inning when Herrera homered to left center, bringing in Scott II. The fourth inning saw Fermín double to left, scoring both Gorman and Walker, extending the Cardinals' lead to 4-0. The Brewers managed to get on the board in the fifth inning with a sacrifice fly from Chourio, allowing Ortiz to score. However, the Cardinals added another run in the eighth inning when Fermín walked, bringing Herrera home and solidifying their lead.
In terms of injuries, the Cardinals were dealing with several key players on the injured list, including Everson Pereira and Masyn Winn, both on the 10-Day IL, and Andre Pallante on the 15-Day IL. Ramon Urias was listed as day-to-day with an arm issue. The Brewers also faced injury challenges, with players like Rob Zastryzny and Brandon Woodruff on the 60-Day IL, which could have affected their performance as they approached the end of the season.
Weather conditions at Busch Stadium were favorable for baseball, contributing to a solid atmosphere for the game. The Cardinals' ability to capitalize on their home advantage was evident, as they improved their home record to 4-2 against the Brewers in their series this season.
The market had priced the Cardinals as significant underdogs, reflecting their lower overall record compared to the Brewers, who were seen as a playoff contender. This game, however, demonstrated that the Cardinals could rise to the occasion, especially in front of their home crowd.
Overall, this game highlighted the Cardinals' resilience and ability to perform when it mattered most, particularly against a strong opponent like the Brewers. Fans and analysts alike will be watching closely to see if the Cardinals can maintain this level of play as the season winds down.
Injury report
- Everson Pereira10-Day-ILHandSt. Louis Cardinals
- Ramon UriasDay-To-DayArmSt. Louis Cardinals
- Masyn Winn10-Day-ILThumbSt. Louis Cardinals
- Andre Pallante15-Day-ILElbowSt. Louis Cardinals
- JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
- Rob Zastryzny60-Day-ILShoulderMilwaukee Brewers
- Bryse Wilson15-Day-ILBackMilwaukee Brewers
- Brandon Woodruff60-Day-ILShoulderMilwaukee Brewers
- Quinn Priester60-Day-ILShoulderMilwaukee Brewers
- Angel Zerpa60-Day-ILElbowMilwaukee Brewers
Recent form
St. Louis Cardinals
Last 10: 3-7Streak W13.9 scored · 5.1 allowed per game3-2 at home
- W7-1vs Milwaukee BrewersSep 20
- L2-6vs Cincinnati RedsSep 17
- W3-0vs Cincinnati RedsSep 16
- L6-11vs Cincinnati RedsSep 15
- L8-9at Milwaukee BrewersSep 14
- L2-8at Milwaukee BrewersSep 13
- L2-4at Seattle MarinersSep 11
- L3-5at Seattle MarinersSep 10
- L2-4at Seattle MarinersSep 9
- W4-3vs San Francisco GiantsSep 7
Milwaukee Brewers
Last 10: 7-3Streak L15.9 scored · 3.6 allowed per game2-3 away
- L1-7at St. Louis CardinalsSep 20
- W5-2vs Los Angeles AngelsSep 18
- W9-2vs Los Angeles AngelsSep 17
- W9-2vs Los Angeles AngelsSep 16
- W9-8vs St. Louis CardinalsSep 14
- W8-2vs St. Louis CardinalsSep 13
- L4-5at Texas RangersSep 10
- L0-5at Texas RangersSep 9
- W10-2at Pittsburgh PiratesSep 7
- W4-1at Pittsburgh PiratesSep 6
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Milwaukee | - | 53 | W2 | .621 | 87 |
| Chicago | 9 | 62 | L2 | .557 | 78 |
| St. Louis | 17 | 70 | W2 | .500 | 70 |
| Pittsburgh | 19 | 72 | L1 | .486 | 68 |
| Cincinnati | 20 | 73 | W2 | .479 | 67 |
How the scoring went
- 3rd Inning0-2Herrera homered to left center (419 feet), Scott II scored.
- 4th Inning0-4Fermín doubled to left, Gorman scored and Walker scored.
- 5th Inning1-4Chourio hit sacrifice fly to center, Ortiz scored.
- 8th Inning1-5Fermín walked, Herrera scored, Walker to second, Burleson to third.
Win probability
Above the line favours St. Louis Cardinals, below favours Milwaukee Brewers.
Venue
- Busch StadiumSt. Louis, Missouri
- Attendance32723
- OfficialsJames Hoye, John Libka, D.J. Reyburn, Sean Barber
Elsewhere
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- Saggese hits go-ahead single in the 10th in the Cardinals' 8-6 victory over the Dodgers
- St. Louis Cardinals vs. Los Angeles Dodgers: Game Highlights
- Schlittler sharp, the Yankees score 5 2-out runs in the 10th in a 6-3 win over the Angels
- New York Yankees vs. Los Angeles Angels: Game Highlights
Picks for MLB
MLB rules and settlement
These two, other days
- Brewers Complete Sweep Over Cardinals with 6-4 VictorySep 27, 2026
- Brewers Edge Cardinals in Close Contest at HomeSep 26, 2026
- Brewers Secure Victory Over Cardinals in High-Scoring AffairSep 25, 2026
- Brewers Defeat Cardinals 8-4 at Busch StadiumJul 9, 2026
- Cardinals Dominate Brewers in 5-1 VictoryJul 8, 2026