Cardinals Edge Astros in Close Contest
Sunday, March 22, 2026, 12:05 PM ET · CACTI Park of the Palm Beaches
St. Louis Cardinals 3, Houston Astros 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won St. Louis Cardinals vs Houston Astros?
St. Louis Cardinals beat Houston Astros 3-2 at CACTI Park of the Palm Beaches on March 22, 2026.
In a tightly contested matchup, the St. Louis Cardinals defeated the Houston Astros 3-2 at CACTI Park of the Palm Beaches. This game was significant as it marked the conclusion of a series in which the Cardinals triumphed, winning five out of six encounters against the Astros. The Cardinals have demonstrated their strength in this series, showcasing their ability to capitalize on scoring opportunities.
The Astros entered this game with a home record of 11-14-3, while the Cardinals boasted a stronger away record of 17-9-2. Houston's recent form has been less than stellar, with a record of 4-6 over their last ten games, averaging 3.3 runs scored and allowing 4.5 runs per game. They have shown some resilience, winning their last game against the Los Angeles Angels 6-1, but prior to that, they had lost four consecutive matches. In contrast, the Cardinals have had a mixed bag of results, going 5-5 in their last ten games, although they are currently on a four-game losing streak, having lost their most recent game against the Chicago Cubs 0-2.
At home, the Astros have a record of 3-2 in their last five games, while their away record has been less favorable at 1-4. The Cardinals, however, have fared better on the road, with a home record of 3-1 and an away record of 2-4 in their last five games. This game was pivotal for both teams as they look to improve their standings.
In terms of injuries, the Astros were missing several key players, including Brice Matthews, Mike Burrows, and Carlos Correa, all on the injured list due to various ailments. The Cardinals also faced injury challenges, with Everson Pereira on the 10-Day IL and Ramon Urias listed as Day-To-Day. These injuries could have impacted the depth and performance of both teams throughout the series.
The scoring in the game unfolded in a series of critical plays. The Astros struck first in the second inning when Trammell homered to right center, giving them an early lead. However, the Cardinals quickly responded in the third inning with a homer from Walker, leveling the score at 1-1. The game remained competitive, and in the sixth inning, the Cardinals took the lead 2-1 when Church doubled to left, allowing Moore to score while Urías advanced to third. The Cardinals extended their lead in the seventh inning with a single from Fermín, bringing Mejia home for a 3-1 advantage. The Astros managed to close the gap in the same inning when Biggio grounded out to first, allowing Call to score, but it was not enough to overcome the Cardinals' lead.
The market had priced the game with the Astros as underdogs, reflecting their recent struggles and the Cardinals' favorable away record. The odds indicated a challenging matchup for Houston, and the final outcome aligned with those expectations, as the Astros' win probability was ultimately calculated at 0.0.
As the game concluded, viewers witnessed a blend of power hitting and strategic plays that defined the matchup. The Cardinals' ability to capitalize on scoring opportunities proved decisive, and their pitching managed to hold the Astros at bay. The series has highlighted the Cardinals' dominance over the Astros, and it will be interesting to see how both teams adjust moving forward in the season.
Injury report
- Brice Matthews60-Day-ILKneeHouston Astros
- Mike Burrows15-Day-ILElbowHouston Astros
- Carlos Correa60-Day-ILAnkleHouston Astros
- Brandon Walter60-Day-ILElbowHouston Astros
- Everson Pereira10-Day-ILHandSt. Louis Cardinals
- Ramon UriasDay-To-DayArmSt. Louis Cardinals
- Masyn Winn10-Day-ILThumbSt. Louis Cardinals
- Andre Pallante15-Day-ILElbowSt. Louis Cardinals
- JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
Recent form
Houston Astros
Last 10: 4-6Streak W13.3 scored · 4.5 allowed per game3-2 at home
- W6-1at Los Angeles AngelsSep 28
- L3-4at Los Angeles AngelsSep 27
- L0-6at AthleticsSep 25
- L1-5at AthleticsSep 24
- L3-7vs Seattle MarinersSep 21
- L0-4vs Seattle MarinersSep 20
- W5-2vs Texas RangersSep 18
- W6-5vs Texas RangersSep 17
- W6-3vs Texas RangersSep 16
- L3-8at Atlanta BravesSep 14
St. Louis Cardinals
Last 10: 5-5Streak L43.9 scored · 4.6 allowed per game2-4 away
- L0-2at Chicago CubsSep 28
- L3-7at Chicago CubsSep 27
- L1-12at Chicago CubsSep 26
- L3-4at San Francisco GiantsSep 25
- W9-8at San Francisco GiantsSep 24
- W6-5at San Francisco GiantsSep 23
- W5-1vs Milwaukee BrewersSep 21
- W7-1vs Milwaukee BrewersSep 20
- L2-6vs Cincinnati RedsSep 17
- W3-0vs Cincinnati RedsSep 16
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Milwaukee | - | 53 | W2 | .621 | 87 |
| Chicago | 9 | 62 | L2 | .557 | 78 |
| St. Louis | 17 | 70 | W2 | .500 | 70 |
| Pittsburgh | 19 | 72 | L1 | .486 | 68 |
| Cincinnati | 20 | 73 | W2 | .479 | 67 |
| Houston | - | 69 | W1 | .507 | 71 |
| Texas | 2 | 71 | L1 | .493 | 69 |
| Seattle | 5 | 74 | W2 | .471 | 66 |
| Athletics | 17 | 86 | W1 | .386 | 54 |
| Los Angeles | 18 | 87 | L2 | .379 | 53 |
How the scoring went
- 2nd Inning0-1Trammell homered to right center.
- 3rd Inning1-1Walker homered to center (413 feet).
- 6th Inning2-1Church doubled to left, Moore scored, Urías to third.
- 7th Inning3-1Fermín singled to center, Mejia scored.
- 7th Inning3-2Biggio grounded out to first, Call scored.
Win probability
Above the line favours Houston Astros, below favours St. Louis Cardinals.
Venue
- CACTI Park of the Palm BeachesPalm Beach, Florida
- Attendance3594
- OfficialsJames Jean, Carlos Torres, Emil Jimenez, Ben Phillips
Elsewhere
- Fantasy baseball forecaster: Team hitting ratings
- Fantasy baseball forecaster: Pitcher projections for the next 10 days
- Fantasy Baseball Reliever Depth Chart
- MLB playoff tracker 2026: Clinching scenarios, bracket, schedule
- MLB betting tips for Thursday: Rays and the road don't seem to be getting along
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Picks for MLB
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These two, other days
- Cardinals Edge Astros in Extra Innings ShowdownApr 19, 2026
- Cardinals Complete Sweep Over Astros in Close ContestApr 18, 2026
- Cardinals Sweep Astros in Impressive Series FinaleApr 17, 2026
- Cardinals Defeat Astros 4-1 in MLB ClashMar 18, 2026
- Cardinals Edge Astros in Thrilling FinishMar 13, 2026