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MLB · Final

Marlins Secure Series Win Over Cardinals with 4-1 Victory

Wednesday, April 22, 2026, 12:10 PM ET · loanDepot park

Miami Marlins 4, St. Louis Cardinals 1, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won St. Louis Cardinals vs Miami Marlins?

Miami Marlins beat St. Louis Cardinals 4-1 at loanDepot park on April 22, 2026.

Who was favored in St. Louis Cardinals vs Miami Marlins?

Miami Marlins were the favorite at DraftKings, moneyline -156 (about 61% implied). The favorite won.

In a decisive matchup, the Miami Marlins triumphed over the St. Louis Cardinals with a final score of 4-1 at loanDepot park, clinching the series 2-1. This victory is significant as it showcases the Marlins' ability to bounce back after a recent loss to the same opponent just a day prior, where they fell 3-5. The win also reflects Miami's resilience at home, despite their recent struggles, as they now hold a home record of 12-13.

The Marlins entered the game with a record of 3-7 over their last ten games, currently on a one-game losing streak. They have averaged 4.1 runs scored per game while allowing 5.3 runs during this stretch. In contrast, the Cardinals have been in better form, boasting a record of 7-3 in their last ten games and currently on a one-game winning streak. They averaged 5.0 runs scored and allowed 4.6 runs per game in that same span, indicating a more potent offense.

At home, the Marlins have struggled slightly, with a record of 2-3 in their last five games, averaging 4.0 runs scored and 4.6 runs allowed. Meanwhile, the Cardinals have been more successful away, holding a 4-1 record in their last five games with an impressive average of 5.8 runs scored and only 4.0 runs allowed.

The matchup also featured a mix of injuries affecting both teams. The Marlins were without Anthony Bender, Pete Fairbanks, Xavier Edwards, Max Meyer, and Ronny Henriquez, all of whom are on the injured list. The Cardinals had Everson Pereira and Masyn Winn on the injured list, while Ramon Urias was listed as day-to-day with an arm issue.

The betting market reflected Miami's status as the favorite, with DraftKings pricing the Marlins at -156 on the money line, while the Cardinals were set at +129. The total for the game was set at 8.5, with the over at -102 and the under at -118, indicating a close expectation for scoring.

The game conditions were favorable for baseball, contributing to an engaging atmosphere. The scoring plays highlighted the Marlins' offensive efforts, starting with a single by Caissie in the second inning that brought Ramírez home, followed by a walk that allowed Hernández to score. Marsee continued to contribute with a single in the fourth inning, extending the lead to 3-0. Ramírez added another run in the fifth inning, making it 4-0 before the Cardinals finally got on the board in the ninth with a home run from Herrera.

This victory not only boosts the Marlins' confidence but also emphasizes their ability to compete effectively against the Cardinals, especially at home. As the season progresses, both teams will look to build on their respective performances, with the Marlins aiming to improve their home record and the Cardinals seeking to maintain their strong offensive output.

Odds

BookSpreadTotalMoneyline
DraftKingsMIA -156 8.5 o -102 / u -118 St. Louis Cardinals +129 · Miami Marlins -156

What these prices pay on $100 · What these numbers mean

Injury report

  • Anthony Bender15-Day-ILLower LegMiami Marlins
  • Pete Fairbanks15-Day-ILHandMiami Marlins
  • Xavier Edwards10-Day-ILThumbMiami Marlins
  • Max Meyer15-Day-ILNeckMiami Marlins
  • Ronny Henriquez60-Day-ILElbowMiami Marlins
  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Ramon UriasDay-To-DayArmSt. Louis Cardinals
  • Masyn Winn10-Day-ILThumbSt. Louis Cardinals
  • Andre Pallante15-Day-ILElbowSt. Louis Cardinals
  • JJ Wetherholt10-Day-ILWristSt. Louis Cardinals

Recent form

Miami Marlins

Last 10: 3-7Streak L14.1 scored · 5.3 allowed per game2-3 at home

  • L3-5vs St. Louis CardinalsApr 21
  • W5-3vs St. Louis CardinalsApr 20
  • W5-3vs Milwaukee BrewersApr 19
  • L2-5vs Milwaukee BrewersApr 18
  • L5-7vs Milwaukee BrewersApr 17
  • L3-6at Atlanta BravesApr 15
  • L5-6at Atlanta BravesApr 14
  • W10-4at Atlanta BravesApr 13
  • L2-8at Detroit TigersApr 12
  • L1-6at Detroit TigersApr 11

St. Louis Cardinals

Last 10: 7-3Streak W15 scored · 4.6 allowed per game4-1 away

  • W5-3at Miami MarlinsApr 21
  • L3-5at Miami MarlinsApr 20
  • W7-5at Houston AstrosApr 19
  • W9-4at Houston AstrosApr 18
  • W5-3vs Cleveland GuardiansApr 15
  • W6-5vs Cleveland GuardiansApr 14
  • L3-9vs Cleveland GuardiansApr 13
  • L3-9vs Boston Red SoxApr 12
  • W3-2vs Boston Red SoxApr 11
  • W6-1at Washington NationalsApr 8

Standings

TeamGames behindLostStreakWin %Won
Milwaukee-53W2.62187
Chicago962L2.55778
St. Louis1770W2.50070
Pittsburgh1972L1.48668
Cincinnati2073W2.47967
Atlanta-57W1.59383
Philadelphia461L1.56479
Miami1269W2.50771
Washington1775L1.47267
New York2077W1.45063

How the scoring went

  1. 2nd Inning0-1Caissie singled to left, Ramírez scored, Hernández to second.
  2. 2nd Inning0-2Marsee walked, Hernández scored, Jiménez to second, Caissie to third.
  3. 4th Inning0-3Marsee singled to right, Jiménez scored, Sanoja thrown out at third.
  4. 5th Inning0-4Ramírez singled to center, Lopez scored.
  5. 9th Inning1-4Herrera homered to left center (388 feet).

Win probability

Above the line favours Miami Marlins, below favours St. Louis Cardinals.

Venue

  • loanDepot parkMiami, Florida
  • Attendance7593
  • OfficialsJacob Metz, Tom Hanahan, Scott Barry, Manny Gonzalez

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.