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MLB · Final

Diamondbacks Defeat Padres 11-4 at Petco Park

Friday, September 25, 2026, 9:40 PM ET · Petco Park

Arizona Diamondbacks 11, San Diego Padres 4, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Arizona Diamondbacks vs San Diego Padres?

Arizona Diamondbacks beat San Diego Padres 11-4 at Petco Park on September 25, 2026.

Who was favored in Arizona Diamondbacks vs San Diego Padres?

Arizona Diamondbacks were the favorite at DraftKings, moneyline -115 (about 53% implied). The favorite won.

The Arizona Diamondbacks secured a commanding 11-4 victory over the San Diego Padres at Petco Park, marking their second consecutive win in the series, which they now lead 2-0. This matchup showcased the Diamondbacks' offensive prowess, particularly in the middle innings, where they scored eight of their eleven runs.

In terms of recent form, the Padres entered the game with a strong home record of 89-71 and had been performing well, winning eight of their last ten games, with an average of 5.7 runs scored per game and 4.6 runs allowed. They were on a two-game winning streak, having recently defeated the Los Angeles Dodgers in back-to-back games. However, their momentum was halted by the Diamondbacks, who have shown a more mixed form with a record of 5-5 over their last ten games, averaging 4.5 runs scored and 4.4 runs allowed. Despite their inconsistency, the Diamondbacks came into this game riding a three-game winning streak, which they extended with this victory.

The game featured a series of scoring plays that highlighted the Diamondbacks' offensive strategy. In the second inning, the Diamondbacks took an early lead with a run scored by Merrill on a groundout by Campusano, followed by Cronenworth's single that brought Bogaerts home, making it 4-2. The Diamondbacks continued to build their lead with a homer by Arenado in the third inning, followed by a single from Moreno in the fourth that scored Nootbaar. The sixth inning was particularly damaging for the Padres, as Perdomo's double brought in three runs, extending the Diamondbacks' lead to 10-2.

The Padres managed to score four runs in total, with Cronenworth contributing to the scoreline in the seventh inning and Song adding another run in the eighth. However, the Diamondbacks' offensive onslaught proved too much for the Padres to overcome. The final score of 11-4 reflected the Diamondbacks' dominance in this encounter.

In terms of injuries, the Padres were missing several key players, including Miguel Andujar, Gavin Sheets, Jeremiah Estrada, Joe Musgrove, and Lucas Giolito, all of whom were on the injured list. The Diamondbacks also faced injury challenges, with Corbin Burnes, Tyler Locklear, Ryan Thompson, A.J. Puk, and Andrew Saalfrank unavailable due to various injuries.

The betting market, as provided by DraftKings, had the Diamondbacks at -115, indicating a slight favoritism over the Padres, who were at -105. The total for the game was set at 8.0, with the over at -104 and the under at -115, reflecting expectations of a competitive scoring affair.

Conditions at Petco Park were favorable for baseball, contributing to the high-scoring nature of the game. Viewers were treated to a display of offensive skill, particularly from the Diamondbacks, who capitalized on their opportunities effectively throughout the game. The Padres, despite their recent form, were unable to match the Diamondbacks' intensity and scoring efficiency, leading to a decisive defeat.

What we said beforehand

The San Diego Padres will face off against the Arizona Diamondbacks at Petco Park on September 26, 2026, in a matchup that promises to be significant for both teams as they push for playoff positioning. The Padres currently hold a record of 89-70, while the Diamondbacks are close behind at 85-74. This game is particularly noteworthy as Arizona leads the season series 1-0-1, having won their last encounter with a score of 5-1 on August 7, 2026.

In their recent form, the Padres have been strong at home, boasting a record of 8-2 in their last ten games, with an average of 5.7 runs scored per game and 4.6 runs allowed. They are currently on a two-game winning streak, having recently defeated the Los Angeles Dodgers in their last three matchups, with scores of 4-2, 5-1, and 7-0. In contrast, the Diamondbacks have also shown resilience, winning their last five games, including a sweep against the Colorado Rockies, with scores of 7-2 and 12-8. Their overall record in the last ten games stands at 5-5, with an average of 4.5 runs scored and 4.4 runs allowed.

At home, the Padres have been particularly effective, with a home record of 2-0 in their last two games. The Diamondbacks, on the other hand, have a mixed away record of 3-4 in their last ten games, but they have been successful in their recent outings, winning their last three games on the road.

In terms of player performance, the Padres will be looking to their star players, with Fernando Tatis Jr. leading the team with a batting average of .289. Manny Machado has been a key contributor as well, hitting 29 home runs and driving in 87 runs. The Diamondbacks counter with Gabriel Moreno, who boasts a .308 batting average, and Nolan Arenado, also with 29 home runs and 83 RBIs.

Injuries could play a significant role in this matchup. The Padres will be without Miguel Andujar (10-Day IL, wrist), Gavin Sheets (10-Day IL, foot), Jeremiah Estrada (15-Day IL, shoulder), Joe Musgrove (60-Day IL, elbow), and Lucas Giolito (60-Day IL, elbow). The Diamondbacks have their own injury concerns, with Corbin Burnes (15-Day IL, shoulder), Tyler Locklear (60-Day IL, thumb), Ryan Thompson (60-Day IL, back), A.J. Puk (60-Day IL, elbow), and Andrew Saalfrank (60-Day IL, shoulder) unavailable.

The betting market reflects the competitive nature of this game, with DraftKings listing the Padres as the favorites at -133, while the Diamondbacks are at +111. The spread is set at -1.5 for the Padres, with a total of 7.5 runs. The over odds are at -112, and the under odds at -107.

Weather conditions for the game are favorable, with a temperature of 76°F and no precipitation expected. Wind gusts may reach up to 12 mph, which could impact gameplay.

As fans tune in, they should watch for the performance of both teams' key players, the impact of injuries, and how the home-field advantage plays out for the Padres. With both teams vying for a crucial win, this matchup is set to be an exciting encounter.

Odds

BookSpreadTotalMoneyline
DraftKingsARI -115 8 o -104 / u -115 Arizona Diamondbacks -115 · San Diego Padres -105

What these prices pay on $100 · What these numbers mean

Injury report

  • Miguel Andujar10-Day-ILWristSan Diego Padres
  • Gavin Sheets10-Day-ILFootSan Diego Padres
  • Jeremiah Estrada15-Day-ILShoulderSan Diego Padres
  • Joe Musgrove60-Day-ILElbowSan Diego Padres
  • Lucas Giolito60-Day-ILElbowSan Diego Padres
  • Corbin Burnes15-Day-ILShoulderArizona Diamondbacks
  • Tyler Locklear60-Day-ILThumbArizona Diamondbacks
  • Ryan Thompson60-Day-ILBackArizona Diamondbacks
  • A.J. Puk60-Day-ILElbowArizona Diamondbacks
  • Andrew Saalfrank60-Day-ILShoulderArizona Diamondbacks

Recent form

San Diego Padres

Last 10: 8-2Streak W25.7 scored · 4.6 allowed per game2-0 at home

  • W4-2at Los Angeles DodgersSep 25
  • W5-1at Los Angeles DodgersSep 24
  • L0-7at Los Angeles DodgersSep 23
  • W7-6vs Miami MarlinsSep 20
  • W8-2vs Miami MarlinsSep 19
  • W9-3at Colorado RockiesSep 17
  • L3-9at Colorado RockiesSep 16
  • W8-7at Colorado RockiesSep 15
  • W6-4at San Francisco GiantsSep 13
  • W7-5at San Francisco GiantsSep 12

Arizona Diamondbacks

Last 10: 5-5Streak W34.5 scored · 4.4 allowed per game2-1 away

  • W5-3at Colorado RockiesSep 24
  • W7-2at Colorado RockiesSep 23
  • W5-3vs New York YankeesSep 20
  • L2-9vs New York YankeesSep 19
  • L3-4vs Miami MarlinsSep 17
  • L2-4vs Miami MarlinsSep 16
  • W8-7vs Miami MarlinsSep 15
  • L2-6vs Texas RangersSep 13
  • W9-1vs Texas RangersSep 12
  • L2-5at Kansas City RoyalsSep 9

Standings

TeamGames behindLostStreakWin %Won
Los Angeles-62W1.61398
San Diego971L1.55689
Arizona1274W6.53886
San Francisco3395L3.40665
Colorado41103L5.35657

How the scoring went

  1. 1st Inning1-0Nootbaar homered to right center (403 feet).
  2. 1st Inning2-0Perdomo tripled to right, Moreno scored.
  3. 1st Inning3-0Carroll hit sacrifice fly to right, Perdomo scored.
  4. 2nd Inning4-0Lawlar homered to right (334 feet).
  5. 2nd Inning4-1Campusano grounded out to second, Merrill scored, Bogaerts to second.
  6. 2nd Inning4-2Cronenworth singled to center, Bogaerts scored.
  7. 3rd Inning6-2Arenado homered to left (385 feet), Perdomo scored.
  8. 4th Inning7-2Moreno singled to right, Nootbaar scored.
  9. 6th Inning10-2Perdomo doubled to center, Moreno scored, Nootbaar scored and Marte scored.
  10. 7th Inning11-2Lawlar grounded into double play, shortstop to second to first, Arenado scored, Fernandez out at second, Tawa to third.
  11. 7th Inning11-3Cronenworth grounded into fielder's choice to shortstop, Song scored, Campusano out at second.
  12. 8th Inning11-4Song singled to center, Harris scored, France to third.

Win probability

Above the line favours San Diego Padres, below favours Arizona Diamondbacks.

Venue

  • Petco ParkSan Diego, California
  • Attendance44512
  • OfficialsBrennan Miller, Ben May, John Tumpane, Chris Segal

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.