White Sox Defeat Diamondbacks 11-5 at Chase Field
Tuesday, April 21, 2026, 9:40 PM ET · Chase Field
Chicago White Sox 11, Arizona Diamondbacks 5, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won Chicago White Sox vs Arizona Diamondbacks?
Chicago White Sox beat Arizona Diamondbacks 11-5 at Chase Field on April 21, 2026.
Who was favored in Chicago White Sox vs Arizona Diamondbacks?
Arizona Diamondbacks were the favorite at DraftKings, moneyline -140 (about 58% implied). The underdog won.
In a decisive victory, the Chicago White Sox defeated the Arizona Diamondbacks 11-5 at Chase Field. This game marked the conclusion of a three-game series, with the White Sox winning the series 2-1. The White Sox improved their record to 10-14, while the Diamondbacks fell to 13-11.
The White Sox entered the game with a recent record of 6-4 over their last ten games, showcasing a scoring average of 5.2 runs per game while allowing 5.3. Their latest performance included a win against the Houston Astros, where they scored 5 runs and allowed only 1. In contrast, the Diamondbacks struggled, recording a 4-6 record in their last ten games, with an average of 4.1 runs scored and 5.6 runs allowed. They were on a three-game losing streak leading into this matchup, having lost their previous game against the Philadelphia Phillies 1-7.
At home, the Diamondbacks had a record of 2-4 in their last six games, while the White Sox had a better away record of 4-2 in their last six. The matchup at Chase Field saw the Diamondbacks looking to break their losing streak against a White Sox team that had found some momentum.
In terms of head-to-head meetings, the Diamondbacks had a slight edge with a 3-2 record against the White Sox in their last five encounters, but the White Sox had won the most recent game in this series, which took place on April 22, 2026, with a score of 11-7.
Injury concerns also played a role in the game, particularly for the Diamondbacks, who were missing several key players. Corbin Carroll was listed as day-to-day due to a back issue, while Tommy Troy, Ryan Thompson, Ryne Nelson, and Michael Soroka were all on the injured list. The White Sox were also dealing with injuries, including Chris Murphy and Kyle Teel, both on the 15-day IL, and Tanner Murray, who was on the 60-day IL.
The betting odds from DraftKings had the Diamondbacks favored at -140, with a total set at 9.0 runs. The spread was -1.5 in favor of the Diamondbacks, indicating that they were expected to win by at least two runs. However, the game's outcome defied these expectations.
The scoring plays in the game were highlighted by several home runs from the White Sox. Vargas opened the scoring with a homer to left field in the second inning, followed by Montgomery's impressive 440-foot homer to center. The White Sox continued to build their lead, with additional runs scored in the fourth and fifth innings, including a two-run homer by Thomas.
The Diamondbacks managed to score two runs in the fifth inning, but it was not enough to close the gap. The White Sox's Antonacci capped off the scoring with an inside-the-park home run in the ninth inning, further extending their lead.
The game concluded with the White Sox firmly in control, showcasing their offensive strength and ability to capitalize on the Diamondbacks' struggles. As the teams move forward, the Diamondbacks will need to address their recent form and injury issues, while the White Sox will look to build on their winning momentum.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | ARI -140 | 9 o -116 / u -104 | Chicago White Sox +116 · Arizona Diamondbacks -140 |
Injury report
- Corbin CarrollDay-To-DayBackArizona Diamondbacks
- Tommy Troy10-Day-ILShoulderArizona Diamondbacks
- Ryan Thompson60-Day-ILBackArizona Diamondbacks
- Ryne Nelson60-Day-ILElbowArizona Diamondbacks
- Michael Soroka15-Day-ILShoulderArizona Diamondbacks
- Chris Murphy15-Day-ILForearmChicago White Sox
- Kyle Teel10-Day-ILAnkleChicago White Sox
- Davis Martin15-Day-ILFingerChicago White Sox
- Prelander Berroa60-Day-ILElbowChicago White Sox
- Tanner Murray60-Day-ILShoulderChicago White Sox
Recent form
Arizona Diamondbacks
Last 10: 4-6Streak L34.1 scored · 5.6 allowed per game2-4 at home
- L1-7vs Philadelphia PhilliesSep 2
- L1-2vs Philadelphia PhilliesSep 1
- L2-7at San Francisco GiantsAug 30
- W10-6at San Francisco GiantsAug 29
- L1-6at San Francisco GiantsAug 28
- W5-4vs Chicago CubsAug 26
- L0-7vs Chicago CubsAug 25
- L5-11vs Cincinnati RedsAug 23
- W9-0vs Cincinnati RedsAug 22
- W7-6at Boston Red SoxAug 19
Chicago White Sox
Last 10: 6-4Streak W15.2 scored · 5.3 allowed per game2-2 away
- W5-1at Houston AstrosSep 2
- L3-6at Houston AstrosSep 1
- L1-5at Minnesota TwinsAug 30
- W7-4at Minnesota TwinsAug 29
- W10-4vs Texas RangersAug 26
- W11-7vs Texas RangersAug 25
- L2-11vs Texas RangersAug 24
- W2-1vs New York MetsAug 23
- L5-10vs New York MetsAug 22
- W6-4vs New York MetsAug 21
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Chicago | - | 65 | W1 | .529 | 73 |
| Cleveland | 3 | 68 | W2 | .507 | 70 |
| Minnesota | 6.5 | 72 | W3 | .482 | 67 |
| Detroit | 10 | 75 | L3 | .457 | 63 |
| Kansas City | 11.5 | 77 | L2 | .446 | 62 |
| Los Angeles | - | 56 | L1 | .594 | 82 |
| San Diego | 9.5 | 66 | L1 | .525 | 73 |
| Arizona | 10 | 67 | L3 | .521 | 73 |
| San Francisco | 25.5 | 82 | L1 | .410 | 57 |
| Colorado | 29.5 | 86 | W1 | .381 | 53 |
How the scoring went
- 1st Inning2-0Montgomery doubled to center, Benintendi scored and Murakami scored, Vargas to third.
- 1st Inning3-0Pereira hit sacrifice fly to right, Vargas scored, Montgomery to third.
- 1st Inning4-0Antonacci tripled to center, Montgomery scored.
- 2nd Inning5-0Murakami homered to right (426 feet).
- 2nd Inning6-0Vargas homered to left (372 feet).
- 2nd Inning7-0Montgomery homered to center (440 feet).
- 4th Inning7-1Gurriel Jr. grounded out to shortstop, Perdomo scored.
- 5th Inning8-1McGuire hit sacrifice bunt to pitcher, Meidroth scored, Peters to second.
- 5th Inning8-2Thomas homered to left center (415 feet).
- 9th Inning10-2Antonacci inside-the-park homered to left (57 feet), Pereira scored.
- 9th Inning11-2Benintendi grounded into double play, pitcher to shortstop to first, Meidroth scored, McGuire out at second, Peters to third.
- 9th Inning11-5Vargas homered to right (374 feet), Fernandez scored and Arenado scored.
Win probability
Above the line favours Arizona Diamondbacks, below favours Chicago White Sox.
Venue
- Chase FieldPhoenix, Arizona
- Attendance23045
- OfficialsDoug Eddings, Jeremie Rehak, Cory Blaser, Adam Beck
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