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MLB · Final

Astros Secure Series Win Against Guardians

Sunday, June 21, 2026, 2:10 PM ET · Daikin Park

Houston Astros 2, Cleveland Guardians 1, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Cleveland Guardians vs Houston Astros?

Houston Astros beat Cleveland Guardians 2-1 at Daikin Park on June 21, 2026.

Who was favored in Cleveland Guardians vs Houston Astros?

Houston Astros were the favorite at DraftKings, moneyline -132 (about 57% implied). The favorite won.

In a tightly contested game at Daikin Park, the Houston Astros emerged victorious over the Cleveland Guardians with a final score of 2-1. This win allowed the Astros to take the series 2-1, showcasing their ability to capitalize on home advantage. The Astros' record at home now stands at 38-42, while the Guardians fall to 41-38 on the road.

The Astros have shown a mixed bag of form recently, with a record of 5-5 in their last ten games. They have a scoring average of 3.9 runs per game while allowing 4.9. Their recent performances include a strong showing against the Guardians on June 20, where they won decisively 9-3. The Astros have been on a slight upward trend, having won their last two games.

In contrast, the Guardians have struggled lately, recording a disappointing 3-6-1 in their last ten games. They have averaged only 2.9 runs scored per game while allowing 4.3. Their last outing against the Astros on June 20 was a setback, as they lost 9-3. The Guardians are currently on a one-game losing streak.

At home, the Astros have a record of 3-2 in their last five games, while the Guardians have struggled away with a record of 1-3. The previous meetings between these two teams have been competitive, with a head-to-head record of 5-5 over the last two seasons. Notably, the Astros won the last matchup on June 20, which followed a Guardians victory earlier in the season on April 22.

In terms of injuries, the Astros are dealing with several key players on the injured list, including Brice Matthews (60-Day IL, knee), Mike Burrows (15-Day IL, elbow), Carlos Correa (60-Day IL, ankle), and Brandon Walter (60-Day IL, elbow). The Guardians also have injuries affecting their roster, with Slade Cecconi (15-Day IL, arm), Rhys Hoskins (10-Day IL, back), and Shawn Armstrong (60-Day IL, calf) unable to participate.

The betting market, as reported by DraftKings, had the Astros favored at -132, with a spread of -1.5 and a total set at 8.5 runs. The odds for the over were -106.0, while the under was priced at -113.0. The money line for the Astros was -132.0, and for the Guardians, it was 109.0, indicating a competitive matchup.

Conditions during the game were conducive to play, allowing both teams to showcase their skills without weather interruptions. The Astros took an early lead in the first inning when Yordan Alvarez homered to right center, a notable moment that set the tone for the game. In the fourth inning, the Astros extended their lead to 2-0 when Paredes singled to center, scoring Alvarez. The Guardians managed to get on the board in the fifth inning with a groundout from Bazzana, which allowed Halpin to score, but it wasn't enough to overcome the Astros' lead.

Viewers should have noted the Astros' strong offensive start, particularly with Alvarez's impactful home run, and how their pitching managed to hold the Guardians to just one run despite the Guardians' attempts to rally. The final score of 2-1 reflects a well-fought game, with the Astros demonstrating their resilience and ability to execute under pressure.

Odds

BookSpreadTotalMoneyline
DraftKingsHOU -132 8.5 o -106 / u -113 Cleveland Guardians +109 · Houston Astros -132

What these prices pay on $100 · What these numbers mean

Injury report

  • Brice Matthews60-Day-ILKneeHouston Astros
  • Mike Burrows15-Day-ILElbowHouston Astros
  • Carlos Correa60-Day-ILAnkleHouston Astros
  • Brandon Walter60-Day-ILElbowHouston Astros
  • Slade Cecconi15-Day-ILArmCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians

Recent form

Houston Astros

Last 10: 5-5Streak W23.9 scored · 4.9 allowed per game3-2 at home

  • W9-3vs Cleveland GuardiansJun 20
  • W4-2vs Detroit TigersJun 17
  • L3-9vs Detroit TigersJun 16
  • L0-4at Kansas City RoyalsJun 14
  • W10-8at Kansas City RoyalsJun 13
  • L2-3at Los Angeles AngelsJun 11
  • L1-10at Los Angeles AngelsJun 10
  • W5-4at Los Angeles AngelsJun 9
  • L0-5vs AthleticsJun 7
  • W5-1vs AthleticsJun 6

Cleveland Guardians

Last 10: 3-6-1Streak L12.9 scored · 4.3 allowed per game1-3 away

  • L3-9at Houston AstrosJun 20
  • W4-2at Milwaukee BrewersJun 18
  • L4-9at Milwaukee BrewersJun 17
  • L1-2at Milwaukee BrewersJun 16
  • D0-0vs Detroit TigersJun 14
  • W3-1vs Detroit TigersJun 13
  • W3-2vs Detroit TigersJun 12
  • L4-8vs New York YankeesJun 10
  • L2-3vs New York YankeesJun 9
  • L5-7vs New York YankeesJun 8

Standings

TeamGames behindLostStreakWin %Won
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362
Houston-69W1.50771
Texas271L1.49369
Seattle574W2.47166
Athletics1786W1.38654
Los Angeles1887L2.37953

How the scoring went

  1. 1st Inning0-1Alvarez homered to right center (407 feet).
  2. 4th Inning0-2Paredes singled to center, Alvarez scored, Walker to third.
  3. 5th Inning1-2Bazzana grounded out to second, Halpin scored.

Win probability

Above the line favours Houston Astros, below favours Cleveland Guardians.

Venue

  • Daikin ParkHouston, Texas
  • Attendance36807
  • OfficialsEdwin Moscoso, Jen Pawol, Hunter Wendelstedt, Vic Carapazza

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.