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MLB · Final

Astros Defeat Guardians 2-0 in MLB Showdown

Wednesday, April 22, 2026, 1:10 PM ET · Progressive Field

Houston Astros 2, Cleveland Guardians 0, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Houston Astros vs Cleveland Guardians?

Houston Astros beat Cleveland Guardians 2-0 at Progressive Field on April 22, 2026.

Who was favored in Houston Astros vs Cleveland Guardians?

Cleveland Guardians were the favorite at DraftKings, moneyline -168 (about 63% implied). The underdog won.

In a tightly contested game at Progressive Field, the Houston Astros emerged victorious against the Cleveland Guardians, winning 2-0. This matchup was significant as it marked the final game of a three-game series, with the Astros winning the series 2-1. The Guardians, who held a home record of 14-12 prior to this game, were looking to build on their recent success against the Astros, having won the previous game 8-5 on April 21, 2026.

The Guardians entered this game with a mixed record of 5-5 over their last ten games, having averaged 4.8 runs scored per game while allowing 5.5 runs. Their recent form included a win against the Astros, but they had also suffered a loss to them just a day prior, where they fell 2-9. In contrast, the Astros had struggled recently, posting a 3-7 record over their last ten games and averaging 5.0 runs scored while allowing 5.9 runs. The Astros were on a one-game losing streak heading into this matchup, having lost to the Guardians the day before.

At home, the Guardians had a record of 4-2 in their last six games, while the Astros had struggled on the road, managing only a 1-4 record in their last five away games. Historically, the Guardians had a slight edge in their head-to-head meetings, leading the series 5-3 over the last two seasons, including three wins in their last four encounters.

In terms of injuries, the Guardians were missing several key players, including Slade Cecconi (15-Day IL, arm), Rhys Hoskins (10-Day IL, back), and Shawn Armstrong (60-Day IL, calf). The Astros also faced significant injury challenges, with Brice Matthews (60-Day IL, knee), Mike Burrows (15-Day IL, elbow), Carlos Correa (60-Day IL, ankle), and Brandon Walter (60-Day IL, elbow) all unavailable for this game.

The betting odds from DraftKings indicated that the Guardians were favored at -168, with a spread of -1.5 and a total set at 8.0. The over odds were listed at -112.0, while the under odds were at -108.0, reflecting the competitive nature of the matchup.

Conditions at Progressive Field were conducive to baseball, with clear skies and a favorable temperature for players and fans alike. The scoring opened in the first inning when Yordan Alvarez homered to right center, driving in Carlos Correa, who had scored ahead of him. This early lead set the tone for the Astros, who managed to hold the Guardians scoreless throughout the game.

As the game progressed, the Guardians struggled to mount a comeback, unable to capitalize on scoring opportunities. Their inability to score was a stark contrast to their previous performance against the Astros, highlighting the challenges they faced against Houston's pitching. The Guardians' final score of 0 underscored their struggles at the plate, while the Astros' solid defense and pitching kept them in control.

Overall, this game was a testament to the competitive spirit of both teams, with the Astros managing to secure a crucial win on the road, while the Guardians will need to regroup and address their recent inconsistencies as they move forward in the season.

Odds

BookSpreadTotalMoneyline
DraftKingsCLE -168 8 o -112 / u -108 Houston Astros +139 · Cleveland Guardians -168

What these prices pay on $100 · What these numbers mean

Injury report

  • Slade Cecconi15-Day-ILArmCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians
  • Brice Matthews60-Day-ILKneeHouston Astros
  • Mike Burrows15-Day-ILElbowHouston Astros
  • Carlos Correa60-Day-ILAnkleHouston Astros
  • Brandon Walter60-Day-ILElbowHouston Astros

Recent form

Cleveland Guardians

Last 10: 5-5Streak W14.8 scored · 5.5 allowed per game4-2 at home

  • W8-5vs Houston AstrosApr 21
  • L2-9vs Houston AstrosApr 20
  • W8-4vs Baltimore OriolesApr 19
  • W4-2vs Baltimore OriolesApr 18
  • L4-6vs Baltimore OriolesApr 17
  • W4-2vs Baltimore OriolesApr 16
  • L3-5at St. Louis CardinalsApr 15
  • L5-6at St. Louis CardinalsApr 14
  • W9-3at St. Louis CardinalsApr 13
  • L1-13at Atlanta BravesApr 12

Houston Astros

Last 10: 3-7Streak L15 scored · 5.9 allowed per game1-4 away

  • L5-8at Cleveland GuardiansApr 21
  • W9-2at Cleveland GuardiansApr 20
  • L5-7vs St. Louis CardinalsApr 19
  • L4-9vs St. Louis CardinalsApr 18
  • L2-3vs Colorado RockiesApr 17
  • W3-1vs Colorado RockiesApr 16
  • W7-6vs Colorado RockiesApr 15
  • L2-6at Seattle MarinersApr 13
  • L7-8at Seattle MarinersApr 12
  • L6-9at Seattle MarinersApr 11

Standings

TeamGames behindLostStreakWin %Won
Houston-69W1.50771
Texas271L1.49369
Seattle574W2.47166
Athletics1786W1.38654
Los Angeles1887L2.37953
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362

How the scoring went

  1. 1st Inning2-0Alvarez homered to right center (422 feet), Correa scored.

Win probability

Above the line favours Cleveland Guardians, below favours Houston Astros.

Venue

  • Progressive FieldCleveland, Ohio
  • Attendance15722
  • OfficialsAlex Tosi, Jansen Visconti, Andy Fletcher, Derek Thomas

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.