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MLB · Final

Cardinals Edge Guardians in Close Contest at Busch Stadium

Wednesday, April 15, 2026, 1:15 PM ET · Busch Stadium

St. Louis Cardinals 5, Cleveland Guardians 3, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Cleveland Guardians vs St. Louis Cardinals?

St. Louis Cardinals beat Cleveland Guardians 5-3 at Busch Stadium on April 15, 2026.

In a tightly contested match at Busch Stadium, the St. Louis Cardinals triumphed over the Cleveland Guardians with a final score of 5-3. This victory allowed the Cardinals to secure the series, winning two out of three games against the Guardians. The match showcased significant moments from both teams, highlighting their current form and the implications of their recent performances.

The Cardinals entered the game with a home record of 10-8, while the Guardians had a slightly better away record of 10-9. In their last ten games, the Cardinals recorded a 5-5 record, with an average of 4.5 runs scored per game and 5.9 runs allowed. They had recently experienced a mixed bag of results, winning their previous game against the Guardians 6-5 on April 14, but suffering a loss to them just a day prior. Their home performance in the last five games was 3-2, indicating a slight upward trend after a rough start to the season.

Conversely, the Guardians had a record of 4-5-1 in their last ten games, averaging 4.0 runs scored and 4.1 runs allowed. They entered this game on a one-game losing streak, having lost to the Cardinals the day before. Their recent form included a notable win against the Atlanta Braves, where they scored 6-0, but they also faced heavy defeats, including a 1-13 loss to the Braves earlier in the series. The Guardians' away record stood at 2-3 in their last five games, reflecting some struggles on the road.

Historically, the Cardinals have performed well against the Guardians, boasting a 4-1 record in their last five meetings. This included three consecutive wins in 2025, with scores of 7-0, 9-6, and 5-0. The recent series in 2026 saw the Cardinals winning two out of three games, which likely added to their confidence heading into this matchup.

In terms of injuries, the Cardinals faced challenges with several players on the injured list, including Masyn Winn (thumb), Everson Pereira (hand), Andre Pallante (elbow), JJ Wetherholt (wrist), and Peter Strzelecki (forearm), all of whom were sidelined. The Guardians also had key players missing, including Slade Cecconi (arm), Rhys Hoskins (back), and Shawn Armstrong (calf), which could have impacted their performance.

The betting lines for this game, provided by DraftKings, indicated a competitive matchup, with both teams listed at -110 for the money line. The spread was set at 1.5, and the total runs over/under was at 9.0, suggesting that the market anticipated a closely fought contest.

As the game unfolded, the scoring started in the first inning when the Guardians took an early lead with a single from Manzardo, bringing Ramírez home. The Cardinals quickly equalized in the second inning with a single from Pagés, allowing Church to score. The game remained tight until the sixth inning when the Cardinals pulled ahead with a sacrifice fly from Wetherholt, scoring Winn, followed by a two-run single from Burleson that brought Church and Scott II across the plate.

The Guardians responded in the seventh inning with a double from Naylor, scoring Schneemann and Hoskins, narrowing the gap to 4-3. However, the Cardinals answered back with a double from Church, allowing Urías to score, bringing the final tally to 5-3.

The game was played under favorable conditions, contributing to a competitive atmosphere. Fans at Busch Stadium witnessed a thrilling contest, with both teams showcasing their strengths and weaknesses. The Cardinals’ ability to capitalize on scoring opportunities proved decisive, while the Guardians struggled to maintain momentum after their early lead.

Overall, this game not only highlighted the rivalry between the two teams but also reflected their current standings and challenges in the season. The Cardinals’ victory solidified their position in the series and provided a much-needed boost as they look to build on their recent performance.

Odds

BookSpreadTotalMoneyline
DraftKingsSTL -110 9 o -112 / u -108 Cleveland Guardians -110 · St. Louis Cardinals -110

What these prices pay on $100 · What these numbers mean

Injury report

  • Masyn Winn10-Day-ILThumbSt. Louis Cardinals
  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Andre Pallante15-Day-ILElbowSt. Louis Cardinals
  • JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
  • Peter Strzelecki15-Day-ILForearmSt. Louis Cardinals
  • Slade Cecconi15-Day-ILArmCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians

Recent form

St. Louis Cardinals

Last 10: 5-5Streak W14.5 scored · 5.9 allowed per game2-2 at home

  • W6-5vs Cleveland GuardiansApr 14
  • L3-9vs Cleveland GuardiansApr 13
  • L3-9vs Boston Red SoxApr 12
  • W3-2vs Boston Red SoxApr 11
  • W6-1at Washington NationalsApr 8
  • W7-6at Washington NationalsApr 7
  • L6-9at Washington NationalsApr 6
  • W5-3at Detroit TigersApr 5
  • L6-11at Detroit TigersApr 4
  • L0-4at Detroit TigersApr 3

Cleveland Guardians

Last 10: 4-5-1Streak L14 scored · 4.1 allowed per game2-3 away

  • L5-6at St. Louis CardinalsApr 14
  • W9-3at St. Louis CardinalsApr 13
  • L1-13at Atlanta BravesApr 12
  • W6-0at Atlanta BravesApr 11
  • L5-11at Atlanta BravesApr 10
  • W10-2vs Kansas City RoyalsApr 8
  • W2-1vs Kansas City RoyalsApr 7
  • L2-4vs Kansas City RoyalsApr 6
  • L0-1vs Chicago CubsApr 5
  • D0-0vs Chicago CubsApr 4

Standings

TeamGames behindLostStreakWin %Won
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362
Milwaukee-53W2.62187
Chicago962L2.55778
St. Louis1770W2.50070
Pittsburgh1972L1.48668
Cincinnati2073W2.47967

How the scoring went

  1. 1st Inning1-0Manzardo singled to center, Ramírez scored.
  2. 2nd Inning1-1Pagés singled to left, Church scored, Pagés to second.
  3. 6th Inning1-2Wetherholt hit sacrifice fly to right, Winn scored, Scott II to second, Church to third.
  4. 6th Inning1-4Burleson singled to center, Church scored and Scott II scored, Herrera to third.
  5. 7th Inning3-4Naylor doubled to center, Schneemann scored and Hoskins scored.
  6. 7th Inning3-5Church doubled to right, Urías scored.

Win probability

Above the line favours St. Louis Cardinals, below favours Cleveland Guardians.

Venue

  • Busch StadiumSt. Louis, Missouri
  • Attendance22642
  • OfficialsAlex Mackay, Alan Porter, Jim Wolf, Roberto Ortiz

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.