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MLB · Final/11

Padres Edge Brewers in Extra Innings Thriller

Monday, September 22, 2025, 9:40 PM ET · Petco Park

San Diego Padres 5, Milwaukee Brewers 4, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Milwaukee Brewers vs San Diego Padres?

San Diego Padres beat Milwaukee Brewers 5-4 at Petco Park on September 22, 2025.

In a thrilling matchup at Petco Park, the San Diego Padres triumphed over the Milwaukee Brewers with a final score of 5-4 after 11 innings. This victory allowed the Padres to win the series 2-1 against the Brewers, showcasing their resilience in a tightly contested game. The Padres, who have an overall record of 86-71, managed to secure this win despite facing a strong Brewers team that holds a record of 95-62.

The game featured a back-and-forth scoring affair, starting with the Padres taking an early lead in the first inning when Manny Machado scored on a balk. However, the Brewers quickly responded in the second inning, with a single from Durbin allowing Frelick to score, followed by Yelich's two-run single that put Milwaukee ahead 3-1. The Padres fought back, with Iglesias homering in the fifth and later tying the game at 3-3 in the seventh inning when Arraez's single brought Iglesias home.

As the game progressed into extra innings, the Brewers regained the lead in the 10th inning with a run scored by Turang, but the Padres answered back with Sheets grounding into a fielder's choice that allowed Arraez to score. The decisive moment came in the 11th inning when Fermin's single brought Johnson home, sealing the victory for San Diego.

In terms of recent form, the Padres have been somewhat inconsistent, with a record of 5-5 in their last 10 games, including a two-game winning streak. They have averaged 4.0 runs scored while allowing 3.6 runs in that span. At home, their record stands at 2-2 in their last four games. Conversely, the Brewers have struggled recently, losing their last two games against the St. Louis Cardinals, bringing their record in the last 10 games to 6-4, with an average of 5.6 runs scored and 4.0 runs allowed.

In terms of injuries, the Padres are dealing with several key players on the injured list, including Jason Adam (60-Day IL, shoulder), Miguel Andujar (10-Day IL, wrist), Gavin Sheets (10-Day IL, foot), Jeremiah Estrada (15-Day IL, shoulder), and Lucas Giolito (60-Day IL, elbow). The Brewers also have significant injuries, with Rob Zastryzny (60-Day IL, shoulder), Bryse Wilson (15-Day IL, back), Brandon Woodruff (60-Day IL, shoulder), Quinn Priester (60-Day IL, shoulder), and Angel Zerpa (60-Day IL, elbow) all sidelined.

The matchup was also notable for its historical context; the Padres have had the upper hand in recent encounters, winning six out of the last eight meetings against the Brewers, including two victories earlier in the 2025 season. The conditions at Petco Park were conducive to a competitive game, with both teams showing their strengths and weaknesses throughout the contest.

As for the betting market, the odds reflected a competitive matchup, with the home team Padres priced by the provider at a favorable line given their recent form and home advantage.

Fans watching the game were treated to a showcase of clutch hitting and strategic plays, with the Padres demonstrating their ability to perform under pressure, especially in extra innings. The game highlighted the importance of timely hitting and defensive plays, making it a must-watch for baseball enthusiasts.

Injury report

  • Jason Adam60-Day-ILShoulderSan Diego Padres
  • Miguel Andujar10-Day-ILWristSan Diego Padres
  • Gavin Sheets10-Day-ILFootSan Diego Padres
  • Jeremiah Estrada15-Day-ILShoulderSan Diego Padres
  • Lucas Giolito60-Day-ILElbowSan Diego Padres
  • Rob Zastryzny60-Day-ILShoulderMilwaukee Brewers
  • Bryse Wilson15-Day-ILBackMilwaukee Brewers
  • Brandon Woodruff60-Day-ILShoulderMilwaukee Brewers
  • Quinn Priester60-Day-ILShoulderMilwaukee Brewers
  • Angel Zerpa60-Day-ILElbowMilwaukee Brewers

Recent form

San Diego Padres

Last 10: 5-5Streak W24 scored · 3.6 allowed per game2-2 at home

  • W3-2at Chicago White SoxSep 21
  • W7-3at Chicago White SoxSep 20
  • L3-4at Chicago White SoxSep 19
  • L1-6at New York MetsSep 18
  • W7-4at New York MetsSep 17
  • L3-8at New York MetsSep 16
  • W11-3vs Colorado RockiesSep 14
  • L2-4vs Colorado RockiesSep 13
  • W2-0vs Colorado RockiesSep 12
  • L1-2vs Cincinnati RedsSep 11

Milwaukee Brewers

Last 10: 6-4Streak L25.6 scored · 4 allowed per game1-4 away

  • L1-5at St. Louis CardinalsSep 21
  • L1-7at St. Louis CardinalsSep 20
  • W5-2vs Los Angeles AngelsSep 18
  • W9-2vs Los Angeles AngelsSep 17
  • W9-2vs Los Angeles AngelsSep 16
  • W9-8vs St. Louis CardinalsSep 14
  • W8-2vs St. Louis CardinalsSep 13
  • L4-5at Texas RangersSep 10
  • L0-5at Texas RangersSep 9
  • W10-2at Pittsburgh PiratesSep 7

Standings

TeamGames behindLostStreakWin %Won
Milwaukee-53W2.62187
Chicago962L2.55778
St. Louis1770W2.50070
Pittsburgh1972L1.48668
Cincinnati2073W2.47967
Los Angeles-57L2.59082
Arizona967W1.52574
San Diego9.567L2.52173
San Francisco24.582W1.41458
Colorado28.586W2.38654

How the scoring went

  1. 1st Inning0-1Machado scored on a balk, O'Hearn to second on a balk, Merrill to third on a balk.
  2. 1st Inning0-1Machado scored on a balk, O'Hearn to second on a balk, Merrill to third on a balk.
  3. 2nd Inning1-1Durbin singled to left, Frelick scored, Collins to second, Vaughn to third.
  4. 2nd Inning3-1Yelich singled to center, Collins scored and Vaughn scored, Durbin thrown out at third.
  5. 5th Inning3-2Iglesias homered to left center (409 feet).
  6. 7th Inning3-3Arraez singled to right, Iglesias scored, Laureano to third.
  7. 10th Inning4-3Frelick grounded into fielder's choice to shortstop, Turang scored.
  8. 10th Inning4-4Sheets grounded into fielder's choice to first, Arraez scored, Merrill out at second.
  9. 11th Inning4-5Fermin singled to center, Johnson scored.

Win probability

Above the line favours San Diego Padres, below favours Milwaukee Brewers.

Venue

  • Petco ParkSan Diego, California
  • Attendance42371
  • OfficialsRoberto Ortiz, Ben May, Chad Fairchild, Bill Miller

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.