Giants Overcome Cardinals in Dominant Win
Tuesday, September 15, 2026, 7:45 PM ET · Busch Stadium
San Francisco Giants 10, St. Louis Cardinals 3, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won San Francisco Giants vs St. Louis Cardinals?
San Francisco Giants beat St. Louis Cardinals 10-3 at Busch Stadium on September 15, 2026.
Who was favored in San Francisco Giants vs St. Louis Cardinals?
St. Louis Cardinals were the favorite at DraftKings, moneyline -187 (about 65% implied). The underdog won.
In a decisive matchup at Busch Stadium, the San Francisco Giants defeated the St. Louis Cardinals with a final score of 10-3. This victory allowed the Giants to take a 2-1 lead in their three-game series, which has been closely contested, with the series now tied at one win apiece prior to this game. The Giants, who have struggled this season with a record of 63-89, showcased their offensive strength, particularly in the third inning, where they scored five runs to take control of the game.
The Cardinals entered this game with a home record of 75-77 and had been performing well recently, winning three straight games leading up to this matchup. Over their last ten games, the Cardinals boasted a record of 6-4, averaging 5.4 runs scored per game while allowing 4.5 runs. However, their recent form took a hit as they faced a Giants team that was desperate for a win after losing three consecutive games prior to this matchup.
At home, the Cardinals had been strong, winning their last three games and holding a home record of 3-0 in their last three contests. In contrast, the Giants had struggled on the road, with a record of 2-4 in their last six away games. The Giants' recent performance had seen them average 4.1 runs scored per game while allowing 4.8 runs, indicating a need for improvement in both offense and defense.
The injury situation for both teams played a role in the game, particularly for the Cardinals, who were missing several key players. JJ Wetherholt, Peter Strzelecki, Everson Pereira, Blaze Jordan, and Hunter Dobbins were all on the injured list, impacting the team's depth and performance. The Giants were also dealing with injuries, including Victor Bericoto, JT Brubaker, Matt Gage, Willy Adames, and Marcelo Mayer, which limited their options as well.
The odds for this game, as provided by DraftKings, favored the Cardinals at -187, with a spread of -1.5 and a total set at 8.0. The over odds were listed at -106 while the under odds were at -113. This reflected the expectation of a competitive game, although the Giants ultimately outperformed those expectations.
The game conditions were typical for a September evening in St. Louis, which can often be humid and warm, potentially affecting player performance. Fans watching the game were treated to a display of offensive prowess from the Giants, who capitalized on their scoring opportunities, particularly in the third inning where they scored five runs to take a commanding lead.
The scoring plays were highlighted by several key moments. In the third inning, Hill grounded out to shortstop, allowing Cox to score, followed by McCray’s single that brought Lee home. Koss then added to the tally with a single that scored both Cavanaugh and McCray. The Cardinals managed to respond with a sacrifice fly from Herrera, but the Giants' offense was relentless. Basabe and Eldridge contributed additional runs in the fourth and eighth innings, respectively, and Hill capped off the scoring with a homer in the ninth inning.
As the game concluded, the Cardinals were unable to mount a significant comeback, finishing with three runs against the Giants' ten. This game highlighted the Giants' ability to capitalize on scoring chances and their resilience in the face of adversity, while the Cardinals will need to regroup and address their injuries and performance issues as they look to finish the season strong.
What we said beforehand
The St. Louis Cardinals will host the San Francisco Giants at Busch Stadium on September 15, 2026, in a matchup that promises to be intriguing given the teams' recent performances and their current standings. The Cardinals lead the series 1-0 after a narrow 2-1 victory over the Giants on September 14, which adds a layer of competitiveness to this upcoming game.
The Cardinals come into this game with a home record of 75-76, having won three of their last five games, with an average of 3.4 runs scored and 2.4 runs allowed in that span. Their recent form at home has been strong, with a record of 6-4 over their last ten games and an impressive average of 5.4 runs scored against 4.5 allowed. In contrast, the Giants have struggled on the road, holding a record of 62-89 and losing their last three games. They have averaged 4.1 runs scored but have allowed 4.8 runs in their last ten games, which reflects their difficulties in maintaining defensive consistency.
Historically, the Cardinals and Giants have faced each other evenly over the past two seasons, with a head-to-head record of 4-4. Their most recent meetings have been closely contested, with the Giants winning the first game of this series 7-6 on September 9, only for the Cardinals to bounce back with their victory on September 14.
In terms of injuries, the Cardinals will be missing several key players, including JJ Wetherholt, Peter Strzelecki, Everson Pereira, Blaze Jordan, and Hunter Dobbins, all of whom are currently on the injured list. The Giants are also dealing with injuries, with Victor Bericoto, JT Brubaker, Matt Gage, Willy Adames, and Marcelo Mayer on the injured list as well. The absence of these players could significantly impact both teams' performances.
The betting market, as provided by DraftKings, has set the odds with the Cardinals favored at -185 on the moneyline, while the Giants are at +152. The spread is set at -1.5 for the Cardinals, with a total of 8.0 runs for the game, indicating expectations of a moderately high-scoring affair.
Weather conditions for the game are expected to be warm, with a temperature around 93°F and a 65% chance of precipitation. Wind gusts are predicted to reach 9 mph, which could affect the ball's flight and overall gameplay.
As the game approaches, viewers should keep an eye on the performance of key players. For the Cardinals, Alec Burleson leads in batting average at .285 and has driven in 110 runs, while Jordan Walker has hit 28 home runs. On the other hand, the Giants' Jung Hoo Lee boasts a batting average of .277, and Rafael Devers has been a standout with 37 home runs and 98 runs batted in. This matchup not only features teams vying for better positioning but also showcases individual talents that could shine under the spotlight.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | STL -187 | 8 o -106 / u -113 | San Francisco Giants +154 · St. Louis Cardinals -187 |
Injury report
- JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
- Peter Strzelecki15-Day-ILForearmSt. Louis Cardinals
- Everson Pereira10-Day-ILHandSt. Louis Cardinals
- Blaze Jordan10-Day-ILAnkleSt. Louis Cardinals
- Hunter Dobbins15-Day-ILElbowSt. Louis Cardinals
- Victor Bericoto10-Day-ILKneeSan Francisco Giants
- JT Brubaker15-Day-ILRibsSan Francisco Giants
- Matt Gage60-Day-ILElbowSan Francisco Giants
- Willy Adames10-Day-ILElbowSan Francisco Giants
- Marcelo Mayer10-Day-ILForearmSan Francisco Giants
Recent form
St. Louis Cardinals
Last 10: 6-4Streak W35.4 scored · 4.5 allowed per game3-0 at home
- W2-1vs San Francisco GiantsSep 14
- W3-1vs Chicago White SoxSep 13
- W7-3vs Chicago White SoxSep 12
- L1-2at San Francisco GiantsSep 9
- L4-5at San Francisco GiantsSep 8
- L7-10at Colorado RockiesSep 6
- W7-6at Colorado RockiesSep 5
- L2-3at Los Angeles DodgersSep 4
- W8-6at Los Angeles DodgersSep 3
- W13-8at Los Angeles DodgersSep 2
San Francisco Giants
Last 10: 4-6Streak L34.1 scored · 4.8 allowed per game2-4 away
- L1-2at St. Louis CardinalsSep 14
- L4-6vs San Diego PadresSep 13
- L5-7vs San Diego PadresSep 12
- W2-1vs St. Louis CardinalsSep 9
- W5-4vs St. Louis CardinalsSep 8
- L2-4at New York MetsSep 6
- W9-5at New York MetsSep 5
- L6-10at New York MetsSep 4
- L2-5at Pittsburgh PiratesSep 3
- W5-4at Pittsburgh PiratesSep 2
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Los Angeles | - | 59 | W2 | .609 | 92 |
| San Diego | 9.5 | 68 | W8 | .547 | 82 |
| Arizona | 12 | 71 | W1 | .530 | 80 |
| San Francisco | 29.5 | 89 | W1 | .414 | 63 |
| Colorado | 36.5 | 95 | L8 | .367 | 55 |
| Milwaukee | - | 57 | W1 | .623 | 94 |
| Chicago | 10.5 | 68 | L1 | .553 | 84 |
| Pittsburgh | 19 | 76 | L1 | .497 | 75 |
| St. Louis | 19.5 | 77 | L1 | .493 | 75 |
| Cincinnati | 24 | 81 | L2 | .464 | 70 |
How the scoring went
- 1st Inning2-0Eldridge homered to right center (461 feet), Gilbert scored.
- 1st Inning3-0Hill singled to right, Cox scored.
- 1st Inning3-1Burleson homered to right center (376 feet).
- 3rd Inning4-1Hill grounded out to shortstop, Cox scored, Lee to third.
- 3rd Inning5-1McCray singled to center, Lee scored, Cavanaugh to third.
- 3rd Inning7-1Koss singled to right, Cavanaugh scored and McCray scored.
- 3rd Inning7-2Herrera hit sacrifice fly to left, Winn scored.
- 4th Inning8-2Basabe doubled to right, Eldridge scored.
- 8th Inning9-2Eldridge doubled to right, B. Harris scored.
- 8th Inning9-3Gorman singled to right, Fermín scored.
- 9th Inning10-3Hill homered to right center (395 feet).
Win probability
Above the line favours St. Louis Cardinals, below favours San Francisco Giants.
Venue
- Busch StadiumSt. Louis, Missouri
- Attendance26666
- OfficialsJacob Metz, Mark Wegner, Bruce Dreckman, Carlos Torres
Elsewhere
- Bryce Eldridge drives in 3 runs as the Giants cruise to a 10-3 win over Cardinals
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