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MLB · Final/10

Giants Edge Cardinals in Extra-Inning Thriller

Wednesday, September 16, 2026, 1:15 PM ET · Busch Stadium

San Francisco Giants 6, St. Louis Cardinals 5, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won San Francisco Giants vs St. Louis Cardinals?

San Francisco Giants beat St. Louis Cardinals 6-5 at Busch Stadium on September 16, 2026.

Who was favored in San Francisco Giants vs St. Louis Cardinals?

St. Louis Cardinals were the favorite at DraftKings, moneyline -171 (about 63% implied). The underdog won.

In a nail-biting finish at Busch Stadium, the San Francisco Giants triumphed over the St. Louis Cardinals with a final score of 6-5 after 10 innings. This victory allowed the Giants to secure the series win 2-1 against the Cardinals. The game was marked by a series of critical plays and errors that ultimately shaped the outcome.

The Cardinals entered the game with a home record of 75-78, while the Giants had a significantly lower away record of 64-89. Recent form showed the Cardinals at 5-5 over their last ten games, with an average of 4.4 runs scored and 4.7 runs allowed. However, they were on a one-game losing streak, having lost their previous match against the Giants 10-3 the day before. The Giants, on the other hand, had a record of 4-6 in their last ten games, scoring an average of 4.6 runs while allowing 4.7 runs. They were coming off a victory against the Cardinals, which marked their first win in the series after losing the prior game.

In terms of home and away performance, the Cardinals had a home record of 3-1 in their last four games at Busch Stadium, while the Giants were 2-4 in their last six away games. The previous meetings between the two teams in this series had seen the Cardinals win one game and lose two, with the Giants having the upper hand in the latest matchups.

Injury concerns loomed for both teams. The Cardinals were missing Everson Pereira, Blaze Jordan, Hunter Dobbins, and Max Rajcic due to various injuries, including hand, ankle, and elbow issues. The Giants were also affected, with Victor Bericoto, JT Brubaker, Matt Gage, Willy Adames, and Marcelo Mayer all on the injured list, dealing with knee, ribs, and elbow injuries.

The betting market, as provided by DraftKings, had the Cardinals favored at -171 on the money line, with a spread of -1.5 and a total set at 8.0. The odds for the over were -112, while the under was priced at -108. This indicated a competitive matchup where the Cardinals were expected to have the edge, but the Giants' recent form suggested they could be a formidable opponent.

The game conditions featured a typical late-summer evening in St. Louis, which can often lead to unpredictable outcomes in baseball. Fans were treated to a dynamic game that saw several lead changes and critical plays. The scoring began with the Giants taking an early lead, but the Cardinals fought back, showcasing their resilience.

Key moments included a series of errors by the Cardinals that allowed the Giants to capitalize and score runs. In the seventh inning, a throwing error by shortstop Koss led to multiple runs for the Giants, putting them ahead 3-1. The Cardinals responded with a run in the eighth, narrowing the gap to 4-2. As the game progressed into the ninth inning, the intensity heightened with the Cardinals tying the game at 4-4, setting the stage for extra innings.

In the tenth inning, Gilbert's impressive 415-foot homer put the Giants back in the lead at 6-4. The Cardinals managed to score one more run, but it was not enough to overcome the deficit, ending the game at 6-5 in favor of the Giants.

This matchup was a testament to the unpredictability of baseball, where a single play can change the course of the game. Viewers were treated to a thrilling contest filled with strategic plays and moments of brilliance from both teams.

What we said beforehand

The St. Louis Cardinals will host the San Francisco Giants at Busch Stadium on September 16, 2026, in a matchup that is currently tied 1-1 in their series. This game is particularly noteworthy as both teams are looking to gain momentum in their respective seasons, with the Cardinals holding a home record of 75-77 and the Giants at 63-89 overall.

In their recent form, the Cardinals have shown a mixed bag of results. Over their last five games, they have a record of 3-2, scoring an average of 3.2 runs while allowing 3.4 runs per game. Their most recent outing saw them lose to the Giants 10-3 on September 15, following a previous win against them 2-1 on September 14. In their last ten home games, the Cardinals have a record of 5-5, with an average of 4.4 runs scored and 4.7 runs allowed.

On the other hand, the Giants are coming off a win against the Cardinals, which snapped a three-game losing streak. They have a record of 2-3 in their last five games, averaging 4.4 runs scored and allowing 3.8 runs. Their recent performance has been marked by inconsistency, as they have struggled throughout the season with an overall away record of 63-89. In their last ten away games, they have a record of 4-6, scoring an average of 4.6 runs while allowing 4.7 runs per game.

The two teams have faced each other multiple times this season, with the Cardinals holding a slight edge in their head-to-head matchups, boasting a record of 4-5 against the Giants in the 2025 and 2026 seasons. Their most recent meetings have been closely contested, with the Cardinals winning the first game of this series before the Giants bounced back in the second.

In terms of injuries, the Cardinals will be without Everson Pereira (10-Day IL, hand), Blaze Jordan (10-Day IL, ankle), Hunter Dobbins (15-Day IL, elbow), and Max Rajcic (60-Day IL, elbow). The Giants will miss Victor Bericoto (10-Day IL, knee), JT Brubaker (15-Day IL, ribs), Matt Gage (60-Day IL, elbow), Willy Adames (10-Day IL, elbow), and Marcelo Mayer (10-Day IL, forearm). These injuries could significantly impact both teams' lineups and performance on the field.

The betting odds from DraftKings indicate that the Cardinals are favored at -163, while the Giants are priced at +135. The spread is set at -1.5 for the Cardinals, with a total of 8.0 runs for the game. The over odds are at -115.0, and the under odds are at -105.0.

Weather conditions for the game are expected to be warm, with a temperature of 89°F and a 20% chance of precipitation. Winds will be light, gusting at 7 mph, which could have a minimal effect on play.

As the game approaches, viewers should watch for the performances of key players such as Alec Burleson, who leads the Cardinals with a .285 batting average and 111 runs batted in, and Jordan Walker, who has hit 28 home runs this season. For the Giants, Rafael Devers stands out with 37 home runs and 98 runs batted in, alongside Jung Hoo Lee, who boasts a .276 batting average.

This matchup promises to be an exciting encounter as both teams vie for a crucial win in the latter part of the season.

Odds

BookSpreadTotalMoneyline
DraftKingsSTL -171 8 o -112 / u -108 San Francisco Giants +141 · St. Louis Cardinals -171

What these prices pay on $100 · What these numbers mean

Injury report

  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Blaze Jordan10-Day-ILAnkleSt. Louis Cardinals
  • Hunter Dobbins15-Day-ILElbowSt. Louis Cardinals
  • Max Rajcic60-Day-ILElbowSt. Louis Cardinals
  • Victor Bericoto10-Day-ILKneeSan Francisco Giants
  • JT Brubaker15-Day-ILRibsSan Francisco Giants
  • Matt Gage60-Day-ILElbowSan Francisco Giants
  • Willy Adames10-Day-ILElbowSan Francisco Giants
  • Marcelo Mayer10-Day-ILForearmSan Francisco Giants

Recent form

St. Louis Cardinals

Last 10: 5-5Streak L14.4 scored · 4.7 allowed per game3-1 at home

  • L3-10vs San Francisco GiantsSep 15
  • W2-1vs San Francisco GiantsSep 14
  • W3-1vs Chicago White SoxSep 13
  • W7-3vs Chicago White SoxSep 12
  • L1-2at San Francisco GiantsSep 9
  • L4-5at San Francisco GiantsSep 8
  • L7-10at Colorado RockiesSep 6
  • W7-6at Colorado RockiesSep 5
  • L2-3at Los Angeles DodgersSep 4
  • W8-6at Los Angeles DodgersSep 3

San Francisco Giants

Last 10: 4-6Streak W14.6 scored · 4.7 allowed per game2-4 away

  • W10-3at St. Louis CardinalsSep 15
  • L1-2at St. Louis CardinalsSep 14
  • L4-6vs San Diego PadresSep 13
  • L5-7vs San Diego PadresSep 12
  • W2-1vs St. Louis CardinalsSep 9
  • W5-4vs St. Louis CardinalsSep 8
  • L2-4at New York MetsSep 6
  • W9-5at New York MetsSep 5
  • L6-10at New York MetsSep 4
  • L2-5at Pittsburgh PiratesSep 3

Standings

TeamGames behindLostStreakWin %Won
Los Angeles-59W2.60992
San Diego1069L1.54382
Arizona12.572L1.52680
San Francisco2989W2.41864
Colorado3695W1.37156
Milwaukee-57W1.62394
Chicago10.568L1.55384
Pittsburgh1976L1.49775
St. Louis2078L2.49075
Cincinnati2481L2.46470

How the scoring went

  1. 3rd Inning1-0B. Harris grounded into double play, first to shortstop, Cox scored, Eldridge out at second.
  2. 7th Inning3-0Cox singled to right, Knizner scored and Koss scored on throwing error by right fielder Walker, Cox to second.
  3. 7th Inning3-1Walker scored on error, Church safe at first on throwing error by shortstop Koss, Church safe at second on error, Saggese safe at third on error.
  4. 7th Inning3-2Saggese scored on T. Harris wild pitch, Pagés to second on wild pitch by T. Harris, Church to third on wild pitch by T. Harris.
  5. 7th Inning3-2Saggese scored on T. Harris wild pitch, Pagés to second on wild pitch by T. Harris, Church to third on wild pitch by T. Harris.
  6. 8th Inning4-2Knizner singled to left, Whitcomb scored.
  7. 9th Inning4-3Fermín hit sacrifice fly to center, Gorman scored.
  8. 9th Inning4-4Bernal singled to right, Saggese scored, Winn to third.
  9. 10th Inning6-4Gilbert homered to center (415 feet), McCray scored.
  10. 10th Inning6-5Saggese hit sacrifice fly to center, Burleson scored, Scott II to third.

Win probability

Above the line favours St. Louis Cardinals, below favours San Francisco Giants.

Venue

  • Busch StadiumSt. Louis, Missouri
  • Attendance24960
  • OfficialsMark Wegner, Bruce Dreckman, Carlos Torres, Jacob Metz

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.