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MLB · Final

White Sox Edge Cardinals in Thrilling Contest

Saturday, September 12, 2026, 7:15 PM ET · Busch Stadium

Chicago White Sox 6, St. Louis Cardinals 5, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Chicago White Sox vs St. Louis Cardinals?

Chicago White Sox beat St. Louis Cardinals 6-5 at Busch Stadium on September 12, 2026.

Who was favored in Chicago White Sox vs St. Louis Cardinals?

Chicago White Sox were the favorite at DraftKings, moneyline -111 (about 53% implied). The favorite won.

In a closely contested game at Busch Stadium, the Chicago White Sox triumphed over the St. Louis Cardinals with a final score of 6-5. This match was pivotal as it marked the conclusion of a series that was tied 1-1, adding an extra layer of significance to the outcome. The White Sox now improve their record to 77-72, while the Cardinals fall to 73-77.

The Cardinals entered this game struggling, having lost their last three games and holding a record of 5-5 over their last ten. They averaged 5.7 runs scored per game but allowed 5.1 runs, reflecting a defensive vulnerability that has plagued them recently. Their last five games saw them record just one win, with an average of 4.2 runs scored and 5.2 runs allowed. At home, they had a record of 2-1 in their last three games, but their overall performance has been inconsistent.

In contrast, the White Sox have also faced challenges, losing their last three games and posting a 3-7 record over their last ten. They averaged just 3.2 runs scored per game during this stretch while allowing 3.7 runs. Their recent form has been particularly poor, with only one win in their last five games, scoring an average of 3.8 runs and allowing 4.4 runs. Their away record stands at 1-3, indicating difficulties in securing victories outside of their home stadium.

Historically, the Cardinals have had the upper hand in recent meetings, with a record of 2-0-1 against the White Sox in the previous season. Their last three encounters included a win and a draw, suggesting a competitive rivalry. However, the White Sox's victory in this game shifts the momentum in their favor.

In terms of injuries, the Cardinals were missing several key players, including Peter Strzelecki and JJ Wetherholt, both on the injured list, while Jordan Walker was listed as day-to-day with an ankle issue. The White Sox also faced challenges with Tyler Davis on bereavement leave and Drew Thorpe on the 60-day injured list due to an elbow injury, among others.

The betting odds from DraftKings reflected a competitive matchup, with the White Sox at -111 and the Cardinals at -108. The total runs for the game were set at 8.5, indicating expectations for a moderately high-scoring affair. The spread was 1.5, suggesting a close contest.

Conditions at Busch Stadium were typical for a late summer evening, providing a suitable backdrop for an exciting game of baseball. Fans were treated to a back-and-forth contest that showcased both teams' offensive capabilities.

The scoring plays highlighted the thrilling nature of the game. The Cardinals initially took a 3-0 lead in the second inning, thanks to a sacrifice fly from Fermín. However, the White Sox responded with a series of runs, tying the game at 4-4 by the fifth inning. The game remained tight until the eighth inning when Bernal hit a home run, giving the Cardinals a brief lead again at 5-4. Yet, the White Sox were not to be outdone; Grichuk's home run in the ninth inning sealed the victory for Chicago.

Overall, this game was a testament to the competitive spirit of both teams, with the White Sox managing to edge out the Cardinals in a dramatic finish. The performance of both teams will be crucial as they look to improve their standings in the league.

What we said beforehand

The St. Louis Cardinals will host the Chicago White Sox at Busch Stadium on September 12, 2026, with the Cardinals holding a 1-0 lead in the current series. This matchup is particularly noteworthy as both teams are looking to improve their standings in the league, with the Cardinals at a record of 73-75 and the White Sox at 75-72. The game is set to start at 23:15 UTC, and the weather conditions are expected to be warm, with a temperature of 88°F, no precipitation, and gusts reaching 7 mph.

In recent form, the Cardinals have struggled, winning only one of their last five games. Their most recent outing resulted in a victory against the White Sox, where they won 7-3. Prior to that, they faced the San Francisco Giants three times, losing all three games by scores of 5-4 in 11 innings, 2-1, and 7-6. Over the last ten games, the Cardinals have a home record of 5-5, with an average of 5.7 runs scored and 5.1 runs allowed per game. However, they are currently on a three-game losing streak at home, having lost their last three games.

The Chicago White Sox, on the other hand, have also been struggling, with a record of 3-7 in their last ten games. They recently lost to the Pittsburgh Pirates three times in a row, with scores of 9-3, 4-2, and 2-0. Their last win came against the Minnesota Twins, where they dominated with a score of 10-1. The White Sox have a poor away record of 1-3 in their last four games, averaging 3.2 runs scored and 3.7 runs allowed.

In terms of injuries, the Cardinals will be missing several key players. Peter Strzelecki is on the 15-Day Injured List with a forearm issue, while JJ Wetherholt is on the 10-Day IL due to a wrist injury. Jordan Walker is listed as day-to-day with an ankle problem, and Everson Pereira and Blaze Jordan are also on the 10-Day IL with hand and ankle injuries, respectively. The White Sox will be without Tyler Davis due to personal reasons and Drew Thorpe, who is on the 60-Day IL with an elbow injury. Additionally, Huascar Brazoban is on the 15-Day IL with a lat injury, Tanner Murray is on the 60-Day IL with a shoulder issue, and Tommy Pham is on the 10-Day IL with a calf injury.

The betting lines for this matchup, as provided by DraftKings, show the White Sox at -111 moneyline odds, while the Cardinals are slightly behind at -108. The spread is set at 1.5 runs, with a total of 8.5 runs for the game. The over odds are at -106, while the under odds are at -114.

As for what to watch for during the game, Alec Burleson leads the Cardinals with a batting average of .284 and has driven in 106 runs this season. Jordan Walker, despite his injury status, has made an impact with 28 home runs. For the White Sox, Chase Meidroth boasts a batting average of .269, while Munetaka Murakami has hit 31 home runs this season, and Colson Montgomery has 83 RBIs.

This game promises to be an interesting clash as both teams seek to turn their fortunes around and gain momentum as the season progresses.

Odds

BookSpreadTotalMoneyline
DraftKingsCHW -111 8.5 o -106 / u -114 Chicago White Sox -111 · St. Louis Cardinals -108

What these prices pay on $100 · What these numbers mean

Injury report

  • Peter Strzelecki15-Day-ILForearmSt. Louis Cardinals
  • JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
  • Jordan WalkerDay-To-DayAnkleSt. Louis Cardinals
  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Blaze Jordan10-Day-ILAnkleSt. Louis Cardinals
  • Tyler DavisbereavementPersonalChicago White Sox
  • Drew Thorpe60-Day-ILElbowChicago White Sox
  • Huascar Brazoban15-Day-ILLatChicago White Sox
  • Tanner Murray60-Day-ILShoulderChicago White Sox
  • Tommy Pham10-Day-ILCalfChicago White Sox

Recent form

St. Louis Cardinals

Last 10: 5-5Streak L35.7 scored · 5.1 allowed per game2-1 at home

  • L1-2at San Francisco GiantsSep 9
  • L4-5at San Francisco GiantsSep 8
  • L7-10at Colorado RockiesSep 6
  • W7-6at Colorado RockiesSep 5
  • L2-3at Los Angeles DodgersSep 4
  • W8-6at Los Angeles DodgersSep 3
  • W13-8at Los Angeles DodgersSep 2
  • L4-5vs Pittsburgh PiratesAug 30
  • W4-1vs Pittsburgh PiratesAug 29
  • W7-5vs Baltimore OriolesAug 27

Chicago White Sox

Last 10: 3-7Streak L33.2 scored · 3.7 allowed per game1-3 away

  • L0-2vs Pittsburgh PiratesSep 10
  • L2-4vs Pittsburgh PiratesSep 9
  • L3-9vs Pittsburgh PiratesSep 8
  • W10-1vs Minnesota TwinsSep 6
  • L4-6vs Minnesota TwinsSep 5
  • W4-1vs Minnesota TwinsSep 4
  • L0-2at Houston AstrosSep 3
  • W5-1at Houston AstrosSep 2
  • L3-6at Houston AstrosSep 1
  • L1-5at Minnesota TwinsAug 30

Standings

TeamGames behindLostStreakWin %Won
Chicago-72W1.51476
Cleveland1.574L1.50375
Minnesota678W1.47370
Detroit779W3.46669
Kansas City10.583L1.44366
Milwaukee-56W5.62493
Chicago1066W2.55783
Pittsburgh1975L2.49774
St. Louis2076L1.49073
Cincinnati23.579L5.46669

How the scoring went

  1. 2nd Inning0-2Winn doubled to left, Gorman scored and Saggese scored.
  2. 2nd Inning0-3Fermín hit sacrifice fly to center, Winn scored.
  3. 4th Inning1-3C. Montgomery walked, Murakami scored, Meidroth to second, Peters to third.
  4. 4th Inning1-4Church doubled to right, Gorman scored.
  5. 5th Inning2-4Murakami walked, Antonacci scored, Vargas to second, Teel to third.
  6. 5th Inning3-4Grichuk grounded into double play, shortstop to second to first, Teel scored, Murakami out at second, Vargas to third.
  7. 5th Inning4-4Peters singled to center, Vargas scored, Peters out stretching at second.
  8. 8th Inning4-5Bernal homered to right center (421 feet).
  9. 9th Inning6-5Grichuk homered to right (358 feet), Doyle scored.

Win probability

Above the line favours St. Louis Cardinals, below favours Chicago White Sox.

Venue

  • Busch StadiumSt. Louis, Missouri
  • Attendance40387
  • OfficialsAlfonso Marquez, Mike Estabrook, Malachi Moore, Edwin Jimenez

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.