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MLB · Final

Guardians Defeat Reds 10-3 in Series Finale

Sunday, May 17, 2026, 1:40 PM ET · Progressive Field

Cleveland Guardians 10, Cincinnati Reds 3, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Cincinnati Reds vs Cleveland Guardians?

Cleveland Guardians beat Cincinnati Reds 10-3 at Progressive Field on May 17, 2026.

Who was favored in Cincinnati Reds vs Cleveland Guardians?

Cleveland Guardians were the favorite at DraftKings, moneyline -161 (about 62% implied). The favorite won.

In a decisive victory, the Cleveland Guardians triumphed over the Cincinnati Reds with a final score of 10-3 at Progressive Field. This win allowed the Guardians to secure the series 2-1 against their in-state rivals. Cleveland's strong performance was marked by a series of home runs that contributed significantly to their scoring.

The Guardians have been in solid form recently, boasting a record of 7-3 over their last ten games, and they have won their last game, which adds to their momentum. They have averaged 4.9 runs scored per game while allowing just 3.4 runs during this stretch. Their home record stands at 5-3, showcasing their strength at Progressive Field. In contrast, the Reds have struggled, with a record of 4-6 in their last ten games and currently on a one-game losing streak. Cincinnati has averaged 5.4 runs scored but has allowed 5.8 runs per game, indicating defensive vulnerabilities.

The Guardians’ scoring was highlighted by multiple home runs throughout the game. Notably, in the third inning, De La Cruz hit a home run to left center, putting the Reds on the board. However, the Guardians responded with a powerful offensive display, including a home run by Manzardo in the same inning that extended their lead. By the end of the fourth inning, Rocchio and Manzardo had added to the Guardians' score, with Cleveland leading 6-2 by the fifth inning after another home run from Manzardo.

In terms of head-to-head meetings, the Guardians have won two of the last eight encounters against the Reds, indicating a competitive rivalry. The previous games in this series saw the Guardians winning the first and last games while dropping the second. This series win could be a turning point for the Guardians as they continue to build on their recent success.

Injury-wise, the Guardians are facing challenges with several players on the injured list, including Slade Cecconi (15-Day IL, arm), Rhys Hoskins (10-Day IL, back), and Shawn Armstrong (60-Day IL, calf). The Reds also have notable absences, including Graham Ashcraft (60-Day IL, elbow) and Ke'Bryan Hayes (10-Day IL, groin). These injuries have impacted both teams' depth and performance.

The betting market reflected the Guardians' strong position heading into the game, with DraftKings listing Cleveland at -161 on the moneyline and a spread of -1.5. The total runs were set at 8.5, with odds of -117 for the over and -103 for the under. This indicates a belief in a relatively high-scoring game, which ultimately played out as the Guardians showcased their offensive capabilities.

Weather conditions at Progressive Field were favorable for baseball, contributing to a lively atmosphere for the fans. As the game progressed, viewers witnessed a combination of power hitting and strategic plays that defined the Guardians' victory.

Overall, this game not only highlighted the Guardians' offensive prowess but also underscored the challenges faced by the Reds as they look to regain their footing in the league. The Guardians' ability to capitalize on scoring opportunities and their strong home record will be crucial as they move forward in the season.

Odds

BookSpreadTotalMoneyline
DraftKingsCLE -161 8.5 o -117 / u -103 Cincinnati Reds +133 · Cleveland Guardians -161

What these prices pay on $100 · What these numbers mean

Injury report

  • Slade Cecconi15-Day-ILArmCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians
  • Graham Ashcraft60-Day-ILElbowCincinnati Reds
  • Eugenio SuarezDay-To-DayPersonalCincinnati Reds
  • Ke'Bryan Hayes10-Day-ILGroinCincinnati Reds
  • Spencer Steer10-Day-ILWristCincinnati Reds
  • Michael Toglia10-Day-ILShoulderCincinnati Reds

Recent form

Cleveland Guardians

Last 10: 7-3Streak W14.9 scored · 3.4 allowed per game5-3 at home

  • W7-4vs Cincinnati RedsMay 16
  • L6-7vs Cincinnati RedsMay 15
  • W4-2vs Los Angeles AngelsMay 13
  • W3-2vs Los Angeles AngelsMay 12
  • W7-2vs Los Angeles AngelsMay 11
  • L4-5vs Minnesota TwinsMay 10
  • L1-2vs Minnesota TwinsMay 9
  • W6-4vs Minnesota TwinsMay 8
  • W8-5at Kansas City RoyalsMay 7
  • W3-1at Kansas City RoyalsMay 6

Cincinnati Reds

Last 10: 4-6Streak L15.4 scored · 5.8 allowed per game1-3 away

  • L4-7at Cleveland GuardiansMay 16
  • W7-6at Cleveland GuardiansMay 15
  • W15-1vs Washington NationalsMay 14
  • L7-8vs Washington NationalsMay 13
  • L4-10vs Washington NationalsMay 12
  • W5-0vs Houston AstrosMay 10
  • W3-1vs Houston AstrosMay 9
  • L0-10vs Houston AstrosMay 8
  • L3-8at Chicago CubsMay 7
  • L6-7at Chicago CubsMay 6

Standings

TeamGames behindLostStreakWin %Won
Milwaukee-53W2.62187
Chicago962L2.55778
St. Louis1770W2.50070
Pittsburgh1972L1.48668
Cincinnati2073W2.47967
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362

How the scoring went

  1. 1st Inning0-2DeLauter homered to right (371 feet), Ramírez scored.
  2. 3rd Inning1-2De La Cruz homered to left center (400 feet).
  3. 3rd Inning1-4Manzardo homered to right (382 feet), DeLauter scored.
  4. 4th Inning2-4Lowe singled to left, Steer scored, Stewart to second.
  5. 4th Inning2-5Rocchio homered to right center (388 feet).
  6. 5th Inning2-6Manzardo homered to right center (406 feet).
  7. 7th Inning2-8Martínez homered to right (407 feet), Kwan scored.
  8. 8th Inning2-10Ramírez homered to center (407 feet), Rocchio scored.
  9. 9th Inning3-10Myers reached on infield single to third, Dunn scored.

Win probability

Above the line favours Cleveland Guardians, below favours Cincinnati Reds.

Venue

  • Progressive FieldCleveland, Ohio
  • Attendance27388
  • OfficialsDavid Rackley, John Libka, James Hoye, Tyler Jones

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.