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NCAAF · Final

Ole Miss Edges Louisville in Thrilling Showdown

Sunday, September 6, 2026, 7:30 PM ET · Nissan Stadium

Ole Miss Rebels 41, Louisville Cardinals 38, final. Our NCAAF picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Louisville Cardinals vs Ole Miss Rebels?

Ole Miss Rebels beat Louisville Cardinals 41-38 at Nissan Stadium on September 6, 2026.

Who was favored in Louisville Cardinals vs Ole Miss Rebels?

Ole Miss Rebels were the favorite at DraftKings, moneyline -245 (about 71% implied). The favorite won.

In a tightly contested game at Nissan Stadium, the Ole Miss Rebels triumphed over the Louisville Cardinals with a final score of 41-38. This matchup was particularly intriguing as it featured two teams with contrasting recent performances; Ole Miss came into the game with a strong home record of 1-0 and an impressive overall record of 9-1 in their last ten games, while Louisville was looking to recover from a disappointing start to their season, holding a record of 0-1.

The Rebels have been on a remarkable run, winning five consecutive games leading up to this clash, and averaging 35.4 points scored while allowing just 21.1 points per game. Their last five games have seen them average 37.0 points scored and only 16.6 points allowed, showcasing their offensive prowess and defensive resilience. Ole Miss’s last victory before this game was a commanding 38-19 win against the Mississippi State Bulldogs, which further solidified their confidence heading into this matchup.

In contrast, the Cardinals entered the game with a mixed record of 6-4 over their last ten outings, but they were coming off a significant win against the Kentucky Wildcats, where they won 41-0. Louisville's average scoring in their recent games was 28.3 points, with an average of 22.2 points allowed. However, their performance had been inconsistent, as evidenced by their previous loss to the SMU Mustangs, where they were defeated 6-38.

When looking at home and away performances, Ole Miss has been particularly strong at home, boasting a perfect 7-0 record, while Louisville has had a balanced away record of 3-1. This game was crucial for both teams, with Ole Miss aiming to maintain their winning streak and Louisville seeking to bounce back from their earlier loss.

The odds provided by DraftKings indicated that Ole Miss was favored to win by a spread of 6.5 points, with a total set at 54.5. The moneyline reflected Ole Miss at -245.0 and Louisville at +200.0, suggesting that the market expected Ole Miss to secure a victory, albeit with Louisville having some potential for an upset.

In terms of injuries, the block did not specify any key players missing from either side, which meant both teams were likely to field their strongest lineups. This factor often plays a significant role in the outcome of games, especially in high-stakes matchups like this one.

As the game progressed, viewers were treated to a display of offensive fireworks, with both teams exchanging leads and showcasing their scoring capabilities. The high-scoring nature of the game was in line with the expectations set by the betting total, and both teams demonstrated their ability to move the ball effectively.

Ultimately, Ole Miss managed to hold on for the victory, narrowly edging out Louisville in a game that will be remembered for its intensity and competitiveness. The win not only boosted Ole Miss's record to 2-0 but also highlighted their status as a formidable contender this season. Meanwhile, Louisville will need to regroup and address the inconsistencies that have plagued them early in the season as they look to turn things around.

What we said beforehand

The upcoming clash between the Ole Miss Rebels and the Louisville Cardinals at Nissan Stadium promises to be an intriguing matchup as both teams prepare to kick off their seasons. This game is particularly noteworthy as both teams enter with a clean slate, each boasting a record of 0-0. The Rebels have shown impressive form in their recent outings, winning five consecutive games, while the Cardinals will look to build momentum after a mixed bag of results in their last few contests.

The Ole Miss Rebels come into this game with a strong recent record of 9-1 over their last ten games. They have averaged 35.4 points scored per game while allowing 21.1 points, indicating a robust offensive capability paired with a solid defense. Their last five games showcase their dominance, with an average of 37.0 points scored and only 16.6 points allowed. Notable victories include a 34-24 win against the Florida Gators and a 38-19 triumph over the Mississippi State Bulldogs. Their home record stands at an impressive 7-0, which could provide them with a significant advantage in this matchup.

In contrast, the Louisville Cardinals have had a more challenging recent history, finishing their last ten games with a record of 6-4. They have averaged 28.3 points scored and 22.2 points allowed, suggesting they have been competitive but not as dominant as the Rebels. The Cardinals' last five games reflect a record of 2-3, with an average of 24.0 points scored and 20.6 points allowed. Their most recent victory was a commanding 41-0 win against the Kentucky Wildcats, which may serve as a confidence booster heading into this game.

When it comes to home versus away performance, the Rebels have excelled at home with a perfect 7-0 record, while the Cardinals have a balanced away record of 3-1. This could play a crucial role in the dynamics of the game, as the Rebels will be looking to leverage their home-field advantage.

The two teams have not faced each other recently, which adds an element of unpredictability to the matchup. Each squad will be keen to establish their game plan early and set the tone for the season.

In terms of injuries, the block does not provide specific details on player availability, making it difficult to assess how injuries might impact either team's performance. However, any last-minute changes to the lineup could be a factor to watch as the game approaches.

The betting market, as provided by DraftKings, has set the spread at Ole Miss -6.5, indicating they are favored to win by that margin. The total points for the game is set at 55.5, suggesting expectations for a moderately high-scoring affair. The moneyline odds reflect Ole Miss at -258.0 and Louisville at 210.0, further underscoring the Rebels' status as the favorites.

Weather conditions for the game are expected to be warm, with a temperature of 91°F, clear conditions, and wind gusts up to 17 mph. These factors could influence gameplay, particularly in terms of stamina and strategy.

As viewers tune in, they should watch for the Rebels' offensive strategy, which has been potent in recent games, and how the Cardinals respond defensively. The effectiveness of each team's quarterback and the ability to execute plays under pressure will be critical components to observe. Additionally, how the Rebels utilize their home advantage against the Cardinals' away performance will be a key storyline as the game unfolds.

Odds

BookSpreadTotalMoneyline
DraftKingsMISS -6.5 54.5 o -110 / u -110 Louisville Cardinals +200 · Ole Miss Rebels -245

What these prices pay on $100 · What these numbers mean

Leaders

  • Passing yardsTrinidad Chambliss21/36, 336 YDS, 3 TD, 1 INTOle Miss Rebels
  • Rushing yardsKewan Lacy17 CAR, 61 YDS, 1 TDOle Miss Rebels
  • Receiving yardsDeuce Alexander5 REC, 159 YDS, 2 TDOle Miss Rebels
  • Passing yardsLincoln Kienholz18/29, 307 YDS, 2 TDLouisville Cardinals
  • Rushing yardsLincoln Kienholz14 CAR, 69 YDS, 1 TDLouisville Cardinals
  • Receiving yardsTre Richardson4 REC, 83 YDS, 1 TDLouisville Cardinals

Recent form

Ole Miss Rebels

Last 10: 9-1Streak W535.4 scored · 21.1 allowed per game7-0 at home

  • W38-19at Mississippi State BulldogsNov 28
  • W34-24vs Florida GatorsNov 16
  • W49-0vs The Citadel BulldogsNov 8
  • W30-14vs South Carolina GamecocksNov 1
  • W34-26at Oklahoma SoonersOct 25
  • L35-43at Georgia BulldogsOct 18
  • W24-21vs Washington State CougarsOct 11
  • W24-19vs LSU TigersSep 27
  • W45-10vs Tulane Green WaveSep 20
  • W41-35vs Arkansas RazorbacksSep 13

Louisville Cardinals

Last 10: 6-4Streak W128.3 scored · 22.2 allowed per game3-1 away

  • W41-0vs Kentucky WildcatsNov 29
  • L6-38at SMU MustangsNov 22
  • L19-20vs Clemson TigersNov 15
  • L26-29vs California Golden BearsNov 9
  • W28-16at Virginia Tech HokiesNov 1
  • W38-24vs Boston College EaglesOct 25
  • W24-21at Miami HurricanesOct 17
  • L27-30vs Virginia CavaliersOct 4
  • W34-27at Pittsburgh PanthersSep 27
  • W40-17vs Bowling Green FalconsSep 20

Standings

TeamOverallIn conference
Miami1-01-0
Virginia1-01-0
Duke1-00-0
Florida State1-00-0
North Carolina1-00-0
Pittsburgh1-00-0
Syracuse1-00-0
Virginia Tech1-00-0
Wake Forest1-00-0
SMU0-00-0
Boston College0-10-0
California0-10-0
Clemson0-10-0
Georgia Tech0-10-0
Louisville0-10-0
Stanford1-10-1
NC State0-10-1
Alabama1-00-0
Arkansas1-00-0
Auburn1-00-0
Florida1-00-0
Georgia1-00-0
Kentucky1-00-0
LSU1-00-0
Mississippi State1-00-0
Missouri1-00-0
Oklahoma1-00-0
Ole Miss1-00-0
South Carolina1-00-0
Tennessee1-00-0
Texas1-00-0
Texas A&M1-00-0
Vanderbilt1-00-0

Box score

StatLouisville CardinalsOle Miss Rebels
First downs2024
Third downs7-166-16
Fourth downs0-11-2
Total yards469488
Net passing yards307336
Completions18/2921/37
Yards per pass10.69.1
Rushing yards162152
Rushing attempts3941
Yards per rush4.23.7
Penalties9-826-60
Turnovers02
Fumbles lost01
Interceptions thrown01
Time of possession30:5829:02

Win probability

Above the line favours Ole Miss Rebels, below favours Louisville Cardinals.

Venue

  • Nissan StadiumNashville, TN
  • Attendance57390

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.