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NCAAF · Final

Louisville Cardinals Edge Pittsburgh Panthers 34-27

Saturday, September 27, 2025, 12:00 PM ET · Acrisure Stadium

Louisville Cardinals 34, Pittsburgh Panthers 27, final. Our NCAAF picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Louisville Cardinals vs Pittsburgh Panthers?

Louisville Cardinals beat Pittsburgh Panthers 34-27 at Acrisure Stadium on September 27, 2025.

In a closely contested match at Acrisure Stadium, the Louisville Cardinals defeated the Pittsburgh Panthers 34-27. This victory extends Louisville's impressive winning streak to six games, while the Panthers have now lost their last two outings. The game showcased the contrasting fortunes of the two teams, with Louisville maintaining an undefeated record of 4-0 for the season, while Pittsburgh's record stands at 2-2.

The Cardinals entered the game with a strong recent form, boasting a record of 8-2 over their last ten games, with an average of 36.5 points scored and 22.9 points allowed. Their last five games have seen them score an average of 39.4 points while allowing only 14.2 points, reflecting their dominant performance. In contrast, the Panthers have struggled, recording a 4-6 record in their last ten games, with an average of 28.4 points scored and 25.2 points allowed. Their recent form has been shaky, with an average of 32.4 points scored and 25.6 points allowed in their last five games, resulting in a record of 2-3.

At home, the Panthers have a record of 4-2, while they have yet to win an away game, standing at 0-4. The Cardinals, on the other hand, have been strong both at home and away, with a 4-1 record in both categories. This fixture was particularly noteworthy as it marked a rematch from the previous season, where the Panthers suffered a significant defeat to the Cardinals, losing 9-37.

In terms of injuries, the block does not specify any current injury concerns for either team, which could have played a role in their respective performances. The market had priced the game with the home team, Pittsburgh, having a 0.0 probability of winning, indicating a strong expectation for a Louisville victory.

The weather conditions for the game were not detailed in the block, but given the time of year, teams often have to contend with variable conditions that can affect play.

Viewers should have watched for Louisville's offensive prowess, which has been a hallmark of their recent success, as well as Pittsburgh's ability to bounce back after their recent losses. The game was a testament to the competitive nature of college football, with both teams showcasing their strengths and weaknesses.

Leaders

  • Passing yardsEli Holstein14/26, 228 YDS, 2 TD, 2 INTPittsburgh Panthers
  • Rushing yardsJa'Kyrian Turner6 CAR, 36 YDSPittsburgh Panthers
  • Receiving yardsCataurus Hicks4 REC, 113 YDS, 1 TDPittsburgh Panthers
  • Passing yardsMiller Moss33/51, 339 YDS, 3 TD, 1 INTLouisville Cardinals
  • Rushing yardsDuke Watson14 CAR, 47 YDSLouisville Cardinals
  • Receiving yardsChris Bell10 REC, 135 YDS, 1 TDLouisville Cardinals

Recent form

Pittsburgh Panthers

Last 10: 4-6Streak L128.4 scored · 25.2 allowed per game4-2 at home

  • L24-31at West Virginia MountaineersSep 13
  • W45-17vs Central Michigan ChippewasSep 6
  • W61-9vs Duquesne DukesAug 30
  • L23-34at Boston College EaglesNov 30
  • L9-37at Louisville CardinalsNov 23
  • L20-24vs Clemson TigersNov 16
  • L19-24vs Virginia CavaliersNov 10
  • L25-48at SMU MustangsNov 3
  • W41-13vs Syracuse OrangeOct 24
  • W17-15vs California Golden BearsOct 12

Louisville Cardinals

Last 10: 8-2Streak W536.5 scored · 22.9 allowed per game4-1 away

  • W40-17vs Bowling Green FalconsSep 20
  • W28-14vs James Madison DukesSep 5
  • W51-17vs Eastern Kentucky ColonelsAug 30
  • W41-14at Kentucky WildcatsNov 30
  • W37-9vs Pittsburgh PanthersNov 23
  • L35-38at Stanford CardinalNov 16
  • W33-21at Clemson TigersNov 2
  • W31-27at Boston College EaglesOct 25
  • L45-52vs Miami HurricanesOct 19
  • W24-20at Virginia CavaliersOct 12

Standings

TeamOverallIn conference
Virginia1-01-0
Florida State1-00-0
North Carolina1-00-0
Stanford1-00-0
Boston College0-00-0
California0-00-0
Clemson0-00-0
Duke0-00-0
Georgia Tech0-00-0
Louisville0-00-0
Miami0-00-0
Pittsburgh0-00-0
SMU0-00-0
Syracuse0-00-0
Virginia Tech0-00-0
Wake Forest0-00-0
NC State0-10-1

Box score

StatLouisville CardinalsPittsburgh Panthers
First downs2314
Third downs9-191-10
Fourth downs0-01-4
Total yards392339
Net passing yards339259
Completions33/5117/32
Yards per pass6.68.1
Rushing yards5380
Rushing attempts3423
Yards per rush1.63.5
Penalties9-926-38
Turnovers15
Fumbles lost02
Interceptions thrown13
Time of possession39:2220:38

Win probability

Above the line favours Pittsburgh Panthers, below favours Louisville Cardinals.

Venue

  • Acrisure StadiumPittsburgh, PA
  • Attendance45301

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.