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MLB · Final

Padres Edge Diamondbacks in Close Contest

Saturday, April 25, 2026, 6:05 PM ET · Estadio Alfredo Harp Helú

San Diego Padres 6, Arizona Diamondbacks 4, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won San Diego Padres vs Arizona Diamondbacks?

San Diego Padres beat Arizona Diamondbacks 6-4 at Estadio Alfredo Harp Helú on April 25, 2026.

Who was favored in San Diego Padres vs Arizona Diamondbacks?

Arizona Diamondbacks were the favorite at DraftKings, moneyline -112 (about 53% implied). The underdog won.

In a tightly contested game, the San Diego Padres defeated the Arizona Diamondbacks 6-4 at Estadio Alfredo Harp Helú, taking a 2-1 lead in their series. The victory showcased the Padres' resilience, especially after trailing early in the game. This matchup was particularly interesting as both teams had been performing well recently, with the series tied 1-1 prior to this game.

The Diamondbacks entered the game with a home record of 14-12 and had been strong at home, winning 7 of their last 10 games, with an impressive average of 5.9 runs scored and 5.1 runs allowed per game during that stretch. Their recent form included a 11-7 win against the Chicago White Sox on April 23, but they were also dealing with a number of injuries, including Tommy Troy, Ryne Nelson, Zac Gallen, Michael Soroka, and Corbin Burnes, all of whom were on the injured list.

On the other side, the Padres boasted an away record of 18-8, having won 8 of their last 10 games prior to this matchup. They had a scoring average of 4.5 runs per game while allowing only 3.6 runs in that same period. However, they faced a setback in their most recent game, losing 8-3 to the Colorado Rockies on April 23. The Padres also had their share of injuries, with Jason Adam, Miguel Andujar, Gavin Sheets, Jeremiah Estrada, and Lucas Giolito all on the injured list.

The game saw a series of scoring plays that kept fans on the edge of their seats. In the second inning, the Diamondbacks jumped out to an early lead as Fernandez doubled to center, scoring Arenado and Vargas, followed by a homer from Thomas that brought Fernandez home, making it 4-0. However, the Padres responded in the fifth inning with a homer from France, cutting the deficit to 4-1.

The seventh inning proved pivotal for San Diego, as they mounted a comeback. Sheets singled to right, scoring Machado and Merrill to make it 4-3. Fermin then hit a sacrifice fly that allowed Bogaerts to score, tying the game at 4-4. The Padres took the lead shortly after when Laureano's sacrifice fly brought Sheets home after an error by the Diamondbacks' right fielder, making it 5-4.

In the ninth inning, France added an insurance run with another homer, sealing the game at 6-4. The final score reflected the Padres' ability to capitalize on opportunities, particularly in the later innings, which has been a hallmark of their recent success.

The betting market reflected a competitive matchup, with DraftKings listing the Diamondbacks at -112 and the Padres at -108, indicating a close contest expected by oddsmakers. The total runs were set at 16.0, with both the over and under at -110.

Overall, this game highlighted the Padres' ability to rally and perform under pressure, while the Diamondbacks will need to address their injury issues and find ways to maintain their offensive momentum at home.

Odds

BookSpreadTotalMoneyline
DraftKingsARI -112 16 o -110 / u -110 San Diego Padres -108 · Arizona Diamondbacks -112

What these prices pay on $100 · What these numbers mean

Injury report

  • Tommy Troy10-Day-ILShoulderArizona Diamondbacks
  • Ryne Nelson60-Day-ILElbowArizona Diamondbacks
  • Zac Gallen60-Day-ILElbowArizona Diamondbacks
  • Michael Soroka15-Day-ILShoulderArizona Diamondbacks
  • Corbin Burnes60-Day-ILElbowArizona Diamondbacks
  • Jason Adam60-Day-ILShoulderSan Diego Padres
  • Miguel Andujar10-Day-ILWristSan Diego Padres
  • Gavin Sheets10-Day-ILFootSan Diego Padres
  • Jeremiah Estrada15-Day-ILShoulderSan Diego Padres
  • Lucas Giolito60-Day-ILElbowSan Diego Padres

Recent form

Arizona Diamondbacks

Last 10: 7-3Streak W15.9 scored · 5.1 allowed per game3-1 at home

  • W11-7vs Chicago White SoxApr 23
  • L5-11vs Chicago White SoxApr 22
  • W6-2vs Toronto Blue JaysApr 19
  • W6-3vs Toronto Blue JaysApr 18
  • W8-5at Baltimore OriolesApr 15
  • W4-3at Baltimore OriolesApr 14
  • L7-9at Baltimore OriolesApr 13
  • W4-3at Philadelphia PhilliesApr 12
  • L3-4at Philadelphia PhilliesApr 11
  • W5-4at Philadelphia PhilliesApr 10

San Diego Padres

Last 10: 8-2Streak L14.5 scored · 3.6 allowed per game2-2 away

  • L3-8at Colorado RockiesApr 23
  • W1-0at Colorado RockiesApr 22
  • W4-1at Los Angeles AngelsApr 19
  • L0-8at Los Angeles AngelsApr 18
  • W5-2vs Seattle MarinersApr 17
  • W7-6vs Seattle MarinersApr 16
  • W4-1vs Seattle MarinersApr 15
  • W9-5vs Colorado RockiesApr 12
  • W5-2vs Colorado RockiesApr 11
  • W7-3vs Colorado RockiesApr 10

Standings

TeamGames behindLostStreakWin %Won
Los Angeles-57L2.59082
Arizona967W1.52574
San Diego9.567L2.52173
San Francisco24.582W1.41458
Colorado28.586W2.38654

How the scoring went

  1. 2nd Inning0-2Fernandez doubled to center, Arenado scored and Vargas scored.
  2. 2nd Inning0-4Thomas homered to right (400 feet), Fernandez scored.
  3. 5th Inning1-4France homered to right center.
  4. 7th Inning3-4Sheets singled to right, Machado scored and Merrill scored, Bogaerts to second.
  5. 7th Inning4-4Fermin hit sacrifice fly to left, Bogaerts scored.
  6. 7th Inning5-4Laureano hit sacrifice fly to right, Sheets scored on error, Cronenworth safe at second on throwing error by right fielder Carroll, France to third.
  7. 9th Inning6-4France homered to right (370 feet).

Win probability

Above the line favours Arizona Diamondbacks, below favours San Diego Padres.

Venue

  • Estadio Alfredo Harp HelúMexico City
  • Attendance19630
  • OfficialsStu Scheurwater, Roberto Ortiz, Jordan Baker, Rob Drake

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.