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MLB · Final

Padres Edge White Sox in Close Contest

Sunday, September 21, 2025, 2:10 PM ET · Rate Field

San Diego Padres 3, Chicago White Sox 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won San Diego Padres vs Chicago White Sox?

San Diego Padres beat Chicago White Sox 3-2 at Rate Field on September 21, 2025.

In a tightly contested game at Rate Field, the San Diego Padres edged out the Chicago White Sox with a final score of 3-2. This victory allowed the Padres to secure the series 2-1 against the White Sox, further solidifying their position as a competitive team in the league.

The Padres, with an away record of 85-71, have shown resilience in their recent form, going 4-6 in their last ten games. They are currently on a one-game winning streak, having scored an average of 3.9 runs while allowing 3.8 runs during this stretch. In contrast, the White Sox, who hold a home record of 58-98, have struggled, posting a record of 3-7 in their last ten games, with an average of 3.0 runs scored and 4.1 runs allowed. The White Sox have lost their last game, continuing a disappointing trend as they have only managed to win once in their last five outings.

The game unfolded with the Padres taking an early lead in the second inning, where Merrill scored due to a pickoff error by pitcher Burke, followed by Cronenworth's single that brought Sheets home, putting the Padres ahead 2-0. Tatis Jr. then extended the lead to 3-0 in the third inning with a powerful home run that traveled 432 feet to left center. The White Sox fought back in the seventh inning, with Vargas walking to allow Fletcher to score, followed closely by Benintendi's walk that brought Meidroth home, narrowing the gap to 3-2.

In terms of home and away performance, the White Sox have struggled at home with a record of 3-4 in their last seven games, while the Padres have displayed a balanced approach with a 2-3 record in their last five away games. Previous meetings between these two teams have seen the White Sox win only once in their last four encounters, showcasing the Padres' dominance in recent matchups.

Injury concerns have also plagued both teams. The White Sox are missing several key players, including Chris Murphy (15-Day IL, forearm), Kyle Teel (10-Day IL, ankle), Tanner Murray (60-Day IL, shoulder), Drew Thorpe (60-Day IL, elbow), and Huascar Brazoban (15-Day IL, lat). The Padres are also dealing with injuries, including Jason Adam (60-Day IL, shoulder), Miguel Andujar (10-Day IL, wrist), Gavin Sheets (10-Day IL, foot), Jeremiah Estrada (15-Day IL, shoulder), and Lucas Giolito (60-Day IL, elbow).

The market reflected the competitive nature of the game, with the White Sox having a home win probability of 0.0% at the conclusion of the match, indicating the odds heavily favored the Padres. This game was played under typical September conditions, which can often influence player performance and game dynamics.

Viewers should have noted the strategic plays, particularly the pivotal errors that led to the Padres' early runs and the White Sox's attempts to rally back. The performance of Tatis Jr., especially his home run, was a highlight, showcasing his ability to change the game's momentum. Overall, this matchup provided a glimpse into the challenges both teams face as the season draws to a close.

Injury report

  • Chris Murphy15-Day-ILForearmChicago White Sox
  • Kyle Teel10-Day-ILAnkleChicago White Sox
  • Tanner Murray60-Day-ILShoulderChicago White Sox
  • Drew Thorpe60-Day-ILElbowChicago White Sox
  • Huascar Brazoban15-Day-ILLatChicago White Sox
  • Jason Adam60-Day-ILShoulderSan Diego Padres
  • Miguel Andujar10-Day-ILWristSan Diego Padres
  • Gavin Sheets10-Day-ILFootSan Diego Padres
  • Jeremiah Estrada15-Day-ILShoulderSan Diego Padres
  • Lucas Giolito60-Day-ILElbowSan Diego Padres

Recent form

Chicago White Sox

Last 10: 3-7Streak L13 scored · 4.1 allowed per game3-4 at home

  • L3-7vs San Diego PadresSep 20
  • W4-3vs San Diego PadresSep 19
  • L1-3vs Baltimore OriolesSep 17
  • L7-8vs Baltimore OriolesSep 16
  • L1-4vs Baltimore OriolesSep 15
  • L2-3at Cleveland GuardiansSep 14
  • L1-3at Cleveland GuardiansSep 13
  • L0-4at Cleveland GuardiansSep 12
  • W5-1vs Tampa Bay RaysSep 11
  • W6-5vs Tampa Bay RaysSep 10

San Diego Padres

Last 10: 4-6Streak W13.9 scored · 3.8 allowed per game2-3 away

  • W7-3at Chicago White SoxSep 20
  • L3-4at Chicago White SoxSep 19
  • L1-6at New York MetsSep 18
  • W7-4at New York MetsSep 17
  • L3-8at New York MetsSep 16
  • W11-3vs Colorado RockiesSep 14
  • L2-4vs Colorado RockiesSep 13
  • W2-0vs Colorado RockiesSep 12
  • L1-2vs Cincinnati RedsSep 11
  • L2-4vs Cincinnati RedsSep 10

Standings

TeamGames behindLostStreakWin %Won
Los Angeles-57L2.59082
Arizona967W1.52574
San Diego9.567L2.52173
San Francisco24.582W1.41458
Colorado28.586W2.38654
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362

How the scoring went

  1. 2nd Inning1-0Merrill scored on pickoff error by pitcher Burke, Sheets picked off second.
  2. 2nd Inning1-0Merrill scored on pickoff error by pitcher Burke, Sheets picked off second.
  3. 2nd Inning2-0Cronenworth singled to center, Sheets scored.
  4. 3rd Inning3-0Tatis Jr. homered to left center (432 feet).
  5. 7th Inning3-1Vargas walked, Fletcher scored, Montgomery to second, Meidroth to third.
  6. 7th Inning3-2Benintendi walked, Meidroth scored, Vargas to second, Montgomery to third.

Win probability

Above the line favours Chicago White Sox, below favours San Diego Padres.

Venue

  • Rate FieldChicago, Illinois
  • Attendance24205
  • OfficialsLance Barrett, Laz Diaz, Erich Bacchus, Mike Estabrook

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.