Pirates Shut Out Cardinals in Key Matchup
Tuesday, September 22, 2026, 6:40 PM ET · PNC Park
Pittsburgh Pirates 2, St. Louis Cardinals 0, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
The next free pick, for your email
Team, bet, price and the hash it was sealed under, on this page the moment you send. Lose or win, it stays public.
or by email
Public record of the main pick, losses included: 115 won, 44 lost. See every pick
One free pick a day by email until you unsubscribe, in one click. 21+.
Quick answers
Who won St. Louis Cardinals vs Pittsburgh Pirates?
Pittsburgh Pirates beat St. Louis Cardinals 2-0 at PNC Park on September 22, 2026.
Who was favored in St. Louis Cardinals vs Pittsburgh Pirates?
Pittsburgh Pirates were the favorite at DraftKings, moneyline -169 (about 63% implied). The favorite won.
The Pittsburgh Pirates secured a decisive 2-0 victory over the St. Louis Cardinals at PNC Park, extending their lead in the series to 2-0. This win is significant as it highlights the Pirates' strong recent form, particularly at home, where they have now won five consecutive games. Pittsburgh's record improved to 81-77, while the Cardinals fell to 76-82.
In their last ten games, the Pirates have posted a record of 6-4, with an impressive streak of four straight wins. During this stretch, they have averaged 4.1 runs scored per game while allowing 4.6 runs. The Pirates' recent performances at home have been particularly strong, as they have won four of their last five games at PNC Park, averaging 5.8 runs scored and allowing 4.4 runs in those contests.
Conversely, the Cardinals have struggled recently, with a record of 4-6 over their last ten games. They are on a one-game winning streak, having won their last game against the Washington Nationals, but their overall away performance has been disappointing, with an 0-3 record in their last three away games. St. Louis has averaged just 3.8 runs scored while allowing 5.0 runs over their last ten games.
The teams have met multiple times this season, with the Pirates holding a slight edge in their head-to-head record at 12-10. In their most recent encounter prior to this game on August 30, the Pirates won 5-4, showcasing their competitive spirit against the Cardinals.
In terms of injuries, the Pirates were without several key players, including Isaac Mattson (hip), Esmerlyn Valdez (hamstring), Braxton Ashcraft (arm), Mitch Keller (arm), and Endy Rodriguez (hip), all of whom are on the injured list. The Cardinals also faced challenges, missing Everson Pereira (hand), Blaze Jordan (ankle), Joshua Baez (oblique), Hunter Dobbins (elbow), and Max Rajcic (elbow).
The betting market, as provided by DraftKings, had the Pirates favored at -169 with a spread of -1.5 and a total of 7.0 runs. The odds for the over were set at -115, while the under was priced at -104. This indicates a belief in a competitive matchup, but ultimately, the Pirates' performance proved dominant.
The scoring in the game came primarily in the later innings. In the sixth inning, O'Hearn singled to left field, allowing Cruz to score the first run of the game. The Pirates then added another run in the seventh inning when Horwitz scored on a wild pitch from Winquest, which also resulted in Griffin being out at third base on a fielder's choice. This sequence of events solidified the Pirates' lead and ultimately secured their shutout victory.
Overall, this game showcased the Pirates' ability to capitalize on scoring opportunities while their pitching staff effectively kept the Cardinals at bay, resulting in a well-earned win that continues to bolster their postseason aspirations.
What we said beforehand
The upcoming matchup between the Pittsburgh Pirates and the St. Louis Cardinals at PNC Park is set to be a compelling encounter, particularly as the series is currently tied 1-1. Both teams are looking to gain an edge as they head into the final stretch of the season, with the Pirates holding a home record of 79-77 and the Cardinals at 76-80. This game is crucial for both teams as they aim to improve their standings in the league.
The Pirates have shown a strong recent form, winning four consecutive games. Their last five outings resulted in four wins and one loss, with an impressive scoring average of 5.8 runs per game while allowing an average of 4.4 runs. Their most recent victory came against the Kansas City Royals, where they won 4-3. In their last ten games at home, the Pirates have a record of 6-4, averaging 4.1 runs scored and 4.6 runs allowed.
In contrast, the Cardinals have struggled lately, with a record of 4-6 in their last ten games. They recently snapped a four-game losing streak with a win against the Washington Nationals, where they triumphed 5-3. Their scoring average in the last five games is 3.2 runs, while they have allowed an average of 5.8 runs. The Cardinals' away record has been particularly poor, as they have not won any of their last three games on the road.
Historically, the matchup between these two teams has been competitive, with the Pirates holding a record of 10-12 against the Cardinals in their last 22 meetings, including the current season. The most recent encounters have seen the Pirates secure victories, including a 5-4 win on August 30, 2026.
In terms of injuries, the Pirates are dealing with several key absences. Isaac Mattson (hip), Esmerlyn Valdez (hamstring), Braxton Ashcraft (arm), Mitch Keller (arm), and Endy Rodriguez (hip) are all on the injured list. The Cardinals are also facing challenges, with Everson Pereira (hand), Blaze Jordan (ankle), Joshua Baez (oblique), Hunter Dobbins (elbow), and Max Rajcic (elbow) sidelined.
The betting market reflects the Pirates' current form and home advantage, with DraftKings setting the odds at PIT -169 for the moneyline, while the Cardinals are priced at +140. The spread is set at -1.5 for the Pirates, with a total of 7.0 runs for the game. The over is priced at -115 and the under at -104.
Weather conditions for the game are expected to be cool, with a temperature of 60°F, a 51% chance of precipitation, and gusts of wind reaching up to 16 mph. These factors could influence the gameplay, particularly in terms of pitching and hitting.
As the game approaches, viewers should watch for the performance of key players such as Nick Gonzales, who leads the Pirates with a .302 batting average, and Brandon Lowe, who has hit 33 home runs and driven in 93 runs. For the Cardinals, Alec Burleson is a player to keep an eye on, boasting a .282 batting average and 111 runs batted in, while Jordan Walker has contributed 28 home runs.
This matchup promises to be a thrilling encounter as both teams vie for a crucial win in their respective campaigns.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | PIT -169 | 7 o -115 / u -104 | St. Louis Cardinals +140 · Pittsburgh Pirates -169 |
Injury report
- Isaac Mattson15-Day-ILHipPittsburgh Pirates
- Esmerlyn Valdez10-Day-ILHamstringPittsburgh Pirates
- Braxton Ashcraft15-Day-ILArmPittsburgh Pirates
- Mitch Keller60-Day-ILArmPittsburgh Pirates
- Endy Rodriguez60-Day-ILHipPittsburgh Pirates
- Everson Pereira10-Day-ILHandSt. Louis Cardinals
- Blaze Jordan10-Day-ILAnkleSt. Louis Cardinals
- Joshua Baez10-Day-ILObliqueSt. Louis Cardinals
- Hunter Dobbins15-Day-ILElbowSt. Louis Cardinals
- Max Rajcic60-Day-ILElbowSt. Louis Cardinals
Recent form
Pittsburgh Pirates
Last 10: 6-4Streak W44.1 scored · 4.6 allowed per game4-2 at home
- W4-3vs Kansas City RoyalsSep 20
- W6-5vs Kansas City RoyalsSep 19
- W8-5vs Kansas City RoyalsSep 18
- W7-4vs Milwaukee BrewersSep 17
- L4-5vs Milwaukee BrewersSep 16
- L1-5vs Milwaukee BrewersSep 15
- W4-3at Chicago CubsSep 13
- L3-4at Chicago CubsSep 12
- L2-12at Chicago CubsSep 11
- W2-0at Chicago White SoxSep 10
St. Louis Cardinals
Last 10: 4-6Streak W13.8 scored · 5 allowed per game0-3 away
- W5-3vs Washington NationalsSep 20
- L1-9vs Washington NationalsSep 19
- L5-6vs San Francisco GiantsSep 16
- L3-10vs San Francisco GiantsSep 15
- W2-1vs San Francisco GiantsSep 14
- W3-1vs Chicago White SoxSep 13
- W7-3vs Chicago White SoxSep 12
- L1-2at San Francisco GiantsSep 9
- L4-5at San Francisco GiantsSep 8
- L7-10at Colorado RockiesSep 6
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Milwaukee | - | 59 | L1 | .624 | 98 |
| Chicago | 10.5 | 69 | W2 | .558 | 87 |
| Pittsburgh | 18 | 77 | W5 | .510 | 80 |
| St. Louis | 22 | 81 | L1 | .484 | 76 |
| Cincinnati | 25.5 | 84 | L2 | .462 | 72 |
How the scoring went
- 6th Inning0-1O'Hearn singled to left, Cruz scored.
- 7th Inning0-2Horwitz scored on Winquest wild pitch, Griffin out at third on runner's fielder's choice.
- 7th Inning0-2Horwitz scored on Winquest wild pitch, Griffin out at third on runner's fielder's choice.
- 7th Inning0-2Horwitz scored on Winquest wild pitch, Griffin out at third on runner's fielder's choice.
- 7th Inning0-2Horwitz scored on Winquest wild pitch, Griffin out at third on runner's fielder's choice.
Win probability
Above the line favours Pittsburgh Pirates, below favours St. Louis Cardinals.
Venue
- PNC ParkPittsburgh, Pennsylvania
- Attendance11375
- OfficialsRon Kulpa, John Bacon, Scott Barry, Tom Hanahan
Elsewhere
- Jones takes perfect game into the 6th, Pirates top Cardinals 2-0 for 5th straight win
- Milwaukee Brewers vs. Philadelphia Phillies: Game Highlights
- Braves' Ronald Acuña Jr. day-to-day after fouling ball off leg
- Rangers put Joc Pederson on IL, end Cal Quantrill's season
- Cubs expect Alex Bregman back for playoffs after foul ball to face
- Aaron Judge expected to miss Wild Card series with injury
Picks for MLB
MLB rules and settlement
These two, other days
- Pirates Secure Series Win Over CardinalsSep 24, 2026
- Cardinals Defeat Pirates 5-1 in PNC Park ShowdownSep 23, 2026
- Pirates Edge Cardinals in Thrilling FinishAug 30, 2026
- Pirates Overcome Cardinals 6-2 at Busch StadiumAug 29, 2026
- Cardinals Secure Victory Over Pirates at HomeAug 28, 2026