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MLB · Final

Cardinals Defeat Pirates 5-1 in PNC Park Showdown

Wednesday, September 23, 2026, 6:40 PM ET · PNC Park

St. Louis Cardinals 5, Pittsburgh Pirates 1, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won St. Louis Cardinals vs Pittsburgh Pirates?

St. Louis Cardinals beat Pittsburgh Pirates 5-1 at PNC Park on September 23, 2026.

Who was favored in St. Louis Cardinals vs Pittsburgh Pirates?

Pittsburgh Pirates were the favorite at DraftKings, moneyline -138 (about 58% implied). The underdog won.

In a decisive matchup at PNC Park, the St. Louis Cardinals triumphed over the Pittsburgh Pirates with a final score of 5-1, taking the series lead 2-1. This game was particularly noteworthy as it marked the third meeting between the two teams in a short span, with the Pirates having won the previous encounter just a day earlier.

The Pirates entered this game with an overall record of 80-78, while the Cardinals had a record of 77-81. Pittsburgh had been on a strong run, winning five consecutive games leading up to this match, with an average of 5.4 runs scored and only 3.4 runs allowed in their last five games. Their recent home performance was impressive as well, boasting a 5-2 record in their last seven home games. However, the Cardinals were struggling, having lost their last game against the Pirates and only managing a 4-6 record in their last ten outings.

The game began with the Pirates taking an early lead in the second inning when Lowe homered to right center, putting them ahead 1-0. However, the Cardinals responded strongly in the third inning, scoring four runs to take control of the game. Burleson’s single brought Wetherholt home, tying the game at 1-1. Following that, a wild pitch by Pirates pitcher Curtis allowed Herrera to score, and Burleson advanced to second. Bernal then singled, scoring Burleson and extending the Cardinals' lead to 3-1. The Cardinals continued to capitalize on their momentum, with Winn doubling to center to score Fermín, and Wetherholt later adding another run with a single, making it 5-1.

In terms of injuries, the Pirates were significantly impacted, with several key players on the injured list, including Esmerlyn Valdez (10-Day-IL, hamstring), Isaac Mattson (15-Day-IL, hip), and Mitch Keller (60-Day-IL, shoulder). The Cardinals also faced injury challenges, with Everson Pereira (10-Day-IL, hand) and Blaze Jordan (10-Day-IL, ankle) among those sidelined.

The betting odds provided by DraftKings indicated the Pirates were favored at -138, with a spread of -1.5 and a total set at 7.5. The Cardinals were listed as underdogs with a moneyline of +114. These odds reflected the competitive nature of the matchup, especially given the Pirates' recent form.

The weather conditions during the game were typical for late September, with clear skies and a comfortable temperature, allowing for an enjoyable evening of baseball.

As the game concluded, the Pirates' chances of winning were effectively extinguished, with a final win probability of 0.0% for the home team. This match highlighted the Cardinals' ability to bounce back and assert dominance after their recent struggles, while the Pirates will need to regroup and address their injury woes as they head into the final stretch of the season.

What we said beforehand

The Pittsburgh Pirates will host the St. Louis Cardinals at PNC Park on September 23, 2026, in a matchup that holds significant implications for both teams as the season winds down. Currently, the Pirates lead the series 1-0 after a 2-0 victory over the Cardinals on September 22, showcasing their recent strong form. The Pirates have won five consecutive games, while the Cardinals are struggling, having lost their last match against the Pirates and three of their last four overall.

In their last five games, the Pirates have shown impressive offensive prowess, winning all five and scoring a total of 27 runs, averaging 5.4 runs per game while allowing only 17, which translates to an average of 3.4 runs against. Their recent victories include a series sweep against the Kansas City Royals, where they scored 8-5, 6-5, and 4-3, along with their recent win against the Cardinals. In contrast, the Cardinals have only won one of their last five games, with their most recent loss to the Pirates adding to their woes. They scored just 12 runs in those five games, averaging 2.4 runs per game while allowing 28 runs, averaging 5.6 runs against.

At home, the Pirates have a record of 80-77, with a strong recent home performance of 6-4 over their last ten games and a current five-game winning streak. They have averaged 4.1 runs scored per game at home while allowing 4.6 runs. The Cardinals, on the other hand, have a record of 76-81, and their away form has been poor, with a record of 0-3 in their last three away games. They have averaged just 2.8 runs scored in their last five games, while allowing 30 runs, averaging 6.0 runs against in that span.

In terms of injury updates, the Pirates will be without Esmerlyn Valdez (10-Day IL, hamstring), Isaac Mattson (15-Day IL, hip), Mitch Keller (60-Day IL, shoulder), Braxton Ashcraft (15-Day IL, arm), and Endy Rodriguez (60-Day IL, hip). The Cardinals are also dealing with injuries, including Everson Pereira (10-Day IL, hand), Blaze Jordan (10-Day IL, ankle), Joshua Baez (10-Day IL, oblique), Hunter Dobbins (15-Day IL, elbow), and Max Rajcic (60-Day IL, elbow).

According to DraftKings, the odds for the game are set with the Pirates favored at -143 on the money line, while the Cardinals are at +118. The spread is set at -1.5 for the Pirates, with a total of 7.0 runs for the game. The weather at PNC Park is expected to be 63°F with a 57% chance of precipitation and wind gusts up to 14 mph, which could affect gameplay.

Fans should watch for the performance of Pirates' leader Nick Gonzales, who boasts a batting average of .302, and Brandon Lowe, who leads the team with 33 home runs and 93 RBIs. For the Cardinals, Alec Burleson is a key player to watch, hitting .280 with 111 RBIs, while Jordan Walker contributes with 28 home runs. This matchup not only highlights two teams in contrasting forms but also showcases individual talents that could make a significant impact on the outcome.

Odds

BookSpreadTotalMoneyline
DraftKingsPIT -138 7.5 o -107 / u -112 St. Louis Cardinals +114 · Pittsburgh Pirates -138

What these prices pay on $100 · What these numbers mean

Injury report

  • Esmerlyn Valdez10-Day-ILHamstringPittsburgh Pirates
  • Isaac Mattson15-Day-ILHipPittsburgh Pirates
  • Mitch Keller60-Day-ILShoulderPittsburgh Pirates
  • Braxton Ashcraft15-Day-ILArmPittsburgh Pirates
  • Endy Rodriguez60-Day-ILHipPittsburgh Pirates
  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Blaze Jordan10-Day-ILAnkleSt. Louis Cardinals
  • Joshua Baez10-Day-ILObliqueSt. Louis Cardinals
  • Hunter Dobbins15-Day-ILElbowSt. Louis Cardinals
  • Max Rajcic60-Day-ILElbowSt. Louis Cardinals

Recent form

Pittsburgh Pirates

Last 10: 6-4Streak W54.1 scored · 4.6 allowed per game5-2 at home

  • W2-0vs St. Louis CardinalsSep 22
  • W4-3vs Kansas City RoyalsSep 20
  • W6-5vs Kansas City RoyalsSep 19
  • W8-5vs Kansas City RoyalsSep 18
  • W7-4vs Milwaukee BrewersSep 17
  • L4-5vs Milwaukee BrewersSep 16
  • L1-5vs Milwaukee BrewersSep 15
  • W4-3at Chicago CubsSep 13
  • L3-4at Chicago CubsSep 12
  • L2-12at Chicago CubsSep 11

St. Louis Cardinals

Last 10: 4-6Streak L13.1 scored · 4.2 allowed per game0-3 away

  • L0-2at Pittsburgh PiratesSep 22
  • W5-3vs Washington NationalsSep 20
  • L1-9vs Washington NationalsSep 19
  • L5-6vs San Francisco GiantsSep 16
  • L3-10vs San Francisco GiantsSep 15
  • W2-1vs San Francisco GiantsSep 14
  • W3-1vs Chicago White SoxSep 13
  • W7-3vs Chicago White SoxSep 12
  • L1-2at San Francisco GiantsSep 9
  • L4-5at San Francisco GiantsSep 8

Standings

TeamGames behindLostStreakWin %Won
Milwaukee-59W1.62799
Chicago11.570L1.55487
Pittsburgh1978L1.50680
St. Louis2281W1.48777
Cincinnati25.584W1.46573

How the scoring went

  1. 2nd Inning0-1Lowe homered to right center (434 feet).
  2. 3rd Inning1-1Burleson singled to center, Wetherholt scored, Herrera to third.
  3. 3rd Inning2-1Herrera scored on Curtis wild pitch, Burleson to second on wild pitch by Curtis.
  4. 3rd Inning2-1Herrera scored on Curtis wild pitch, Burleson to second on wild pitch by Curtis.
  5. 3rd Inning3-1Bernal singled to right, Burleson scored.
  6. 4th Inning4-1Winn doubled to center, Fermín scored.
  7. 4th Inning5-1Wetherholt singled to right, Winn scored.

Win probability

Above the line favours Pittsburgh Pirates, below favours St. Louis Cardinals.

Venue

  • PNC ParkPittsburgh, Pennsylvania
  • Attendance13176
  • OfficialsJohn Bacon, Scott Barry, Tom Hanahan, Ron Kulpa

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.