NFL · 11/8 - 4:25 PM EST

Arizona Cardinals vs Seattle Seahawks prediction & odds

Arizona Cardinals3-5

Seattle Seahawks4-4

Sunday, November 8, 2026, 4:25 PM ET · Lumen Field

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Quick answers

When and where is Arizona Cardinals vs Seattle Seahawks?

Arizona Cardinals visit Seattle Seahawks at Lumen Field on November 8, 2026.

Who is favored in Arizona Cardinals vs Seattle Seahawks?

Seattle Seahawks are the favorite at DraftKings: moneyline -700, a price that implies about 88%. Arizona Cardinals are +500.

What are the spread and the over/under for Arizona Cardinals vs Seattle Seahawks?

DraftKings has SEA -12.5, with the total at 41.5.

How are Arizona Cardinals and Seattle Seahawks playing lately?

Seattle Seahawks are 6-4 in their last 10, Arizona Cardinals 3-7.

The Seattle Seahawks will face the Arizona Cardinals at Lumen Field on November 8, 2026. The Seahawks enter the game with a record of 4-4, while the Cardinals sit at 3-5. Seattle has a home record of 3-2 this season, though they are coming off a loss to the Chicago Bears, which ended a brief winning streak. In their last five games, the Seahawks have won two and lost three, averaging 22.0 points scored and allowing 21.8 points per game.

The Cardinals are looking to build on a recent victory against the Dallas Cowboys, which snapped a losing streak. Arizona's away record stands at 3-4, and they have also struggled defensively, allowing an average of 31.4 points in their last five games.

In terms of injuries, the Seahawks have several players listed as questionable, including Rashid Shaheed (knee), Velus Jones Jr. (hamstring), Charles Cross (ankle), Leonard Williams (shoulder), and Brandon Pili (back). The Cardinals will be without James Conner, Jeremiyah Love, and Kendrick Bourne, all on injured reserve, while Walter Nolen III and Jon Gaines II are questionable.

The betting line from DraftKings indicates the Seahawks are favored by 12.5 points, with a total set at 41.5. Weather conditions for the game are expected to be mild, with a temperature around 58°F and a 25% chance of precipitation.

Odds

Book	Spread	Total	Moneyline
DraftKings	SEA -12.5	41.5 o -110 / u -110	Arizona Cardinals +500 · Seattle Seahawks -700

What these prices pay on $100 · What these numbers mean

Injury report

Rashid ShaheedQuestionableKneeSeattle Seahawks
Velus Jones Jr.QuestionableHamstringSeattle Seahawks
Charles CrossQuestionableAnkleSeattle Seahawks
Leonard WilliamsQuestionableShoulderSeattle Seahawks
Brandon PiliQuestionableBackSeattle Seahawks
James ConnerInjured ReserveFootArizona Cardinals
Jeremiyah LoveInjured ReserveAnkleArizona Cardinals
Kendrick BourneInjured ReserveLower LegArizona Cardinals
Walter Nolen IIIQuestionableAnkleArizona Cardinals
Jon Gaines IIQuestionableAnkleArizona Cardinals

Leaders

Passing yardsSam Darnold127/211, 1,478 YDS, 10 TD, 9 INTSeattle Seahawks
Rushing yardsEmanuel Wilson111 CAR, 403 YDS, 3 TDSeattle Seahawks
Receiving yardsJaxon Smith-Njigba64 REC, 985 YDS, 9 TDSeattle Seahawks
Passing yardsJacoby Brissett193/305, 1,719 YDS, 10 TD, 7 INTArizona Cardinals
Rushing yardsTyler Allgeier72 CAR, 323 YDS, 2 TDArizona Cardinals
Receiving yardsTrey McBride66 REC, 544 YDS, 5 TDArizona Cardinals

Recent form

Seattle Seahawks

Last 10: 6-4Streak L122.5 scored · 17.2 allowed per game3-2 at home

W30-23vs Los Angeles ChargersOct 4
L32-29vs San Francisco 49ersOct 11
L17-14 OTvs Denver BroncosOct 15
W20-3vs Kansas City ChiefsOct 25
L34-17vs Chicago BearsNov 2