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NFL · Final

49ers Secure Victory Over Panthers at Levi's Stadium

Monday, November 24, 2025, 8:15 PM ET · Levi's Stadium

San Francisco 49ers 20, Carolina Panthers 9, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Carolina Panthers vs San Francisco 49ers?

San Francisco 49ers beat Carolina Panthers 20-9 at Levi's Stadium on November 24, 2025.

The San Francisco 49ers triumphed over the Carolina Panthers with a final score of 20-9 at Levi's Stadium, solidifying their position in the NFL standings. This victory marks an important win for the 49ers, who improved their record to 9-4, while the Panthers fell to 6-7. The matchup showcased the 49ers' strong home performance, with a home record of 8-4 this season.

In terms of recent form, the 49ers entered the game having won their last match against the Arizona Cardinals with a score of 41-22. Over their last ten games, they have a record of 6-4, averaging 24.4 points scored and allowing 23.9 points per game. Their home record this season stands at 2-2, while they have performed better away with a record of 4-2. The Panthers, on the other hand, also had a record of 6-4 in their last ten games, but their scoring average was lower at 19.7 points, with 22.3 points allowed. They came off a win against the Atlanta Falcons, finishing 30-27.

The matchup was set against a backdrop of significant injuries affecting both teams. The 49ers had several key players listed as questionable, including Sam Okuayinonu (foot), Kyle Juszczyk (finger), Nick Bosa (knee - ACL), Mike Evans (groin), and George Kittle (Achilles). The Panthers also faced challenges, with Jonathon Brooks (general soreness) listed as questionable, and Brady Christensen (hamstring), Ryan Hayes (undisclosed), and Bam Martin-Scott (hamstring) on injured reserve.

The betting market, as provided by DraftKings, had the 49ers favored by 7 points, with a total set at 48.5. The odds for both the over and under were listed at -115. This context highlighted the expectations for a competitive game, although the 49ers ultimately demonstrated their strength on home turf.

Conditions at Levi's Stadium were typical for a late November game, with fans witnessing a spirited contest. The 49ers' defense played a crucial role in limiting the Panthers' scoring opportunities, contributing to the final scoreline.

Viewers were treated to a display of strategic plays and defensive prowess, particularly from the 49ers, who capitalized on their home advantage. The performance of the 49ers' defense, combined with the effectiveness of their offense, was key to their success in this matchup.

Odds

BookSpreadTotalMoneyline
DraftKingsSF -7 48.5 o -115 / u -115 Carolina Panthers — · San Francisco 49ers —

What these prices pay on $100 · What these numbers mean

Injury report

  • Sam OkuayinonuQuestionableFootSan Francisco 49ers
  • Kyle JuszczykQuestionableFingerSan Francisco 49ers
  • Nick BosaQuestionableKnee - ACLSan Francisco 49ers
  • Mike EvansQuestionableGroinSan Francisco 49ers
  • George KittleQuestionableAchillesSan Francisco 49ers
  • Jonathon BrooksQuestionableGeneral SorenessCarolina Panthers
  • Brady ChristensenInjured ReserveHamstringCarolina Panthers
  • Chuba HubbardQuestionableHamstringCarolina Panthers
  • Ryan HayesInjured ReserveUndisclosedCarolina Panthers
  • Bam Martin-ScottInjured ReserveHamstringCarolina Panthers

Leaders

  • Passing yardsBrock Purdy23/32, 193 YDS, 1 TD, 3 INTSan Francisco 49ers
  • Rushing yardsChristian McCaffrey24 CAR, 89 YDS, 1 TDSan Francisco 49ers
  • Receiving yardsGeorge Kittle6 REC, 78 YDSSan Francisco 49ers
  • Passing yardsBryce Young18/29, 169 YDS, 1 TD, 2 INTCarolina Panthers
  • Rushing yardsRico Dowdle6 CAR, 38 YDSCarolina Panthers
  • Receiving yardsRico Dowdle4 REC, 36 YDSCarolina Panthers

Recent form

San Francisco 49ers

Last 10: 6-4Streak W124.4 scored · 23.9 allowed per game2-2 at home

  • W41-22at Arizona CardinalsNov 16
  • L26-42vs Los Angeles RamsNov 9
  • W34-24at New York GiantsNov 2
  • L15-26at Houston TexansOct 26
  • W20-10vs Atlanta FalconsOct 20
  • L19-30at Tampa Bay BuccaneersOct 12
  • W26-23at Los Angeles RamsOct 3
  • L21-26vs Jacksonville JaguarsSep 28
  • W16-15vs Arizona CardinalsSep 21
  • W26-21at New Orleans SaintsSep 14

Carolina Panthers

Last 10: 6-4Streak W119.7 scored · 22.3 allowed per game3-2 away

  • W30-27at Atlanta FalconsNov 16
  • L7-17vs New Orleans SaintsNov 9
  • W16-13at Green Bay PackersNov 2
  • L9-40vs Buffalo BillsOct 26
  • W13-6at New York JetsOct 19
  • W30-27vs Dallas CowboysOct 12
  • W27-24vs Miami DolphinsOct 5
  • L13-42at New England PatriotsSep 28
  • W30-0vs Atlanta FalconsSep 21
  • L22-27at Arizona CardinalsSep 14

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Carolina189970.75033-1
Tampa Bay150400.66722-1
Atlanta145580.66722-1
New Orleans282470.33311-2
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1

Box score

StatCarolina PanthersSan Francisco 49ers
First downs1223
First downs passing911
First downs rushing312
First downs by penalty00
Third downs1-77-13
Fourth downs0-02-2
Offensive plays4370
Total yards230340
Yards per play5.34.9
Drives910
Net passing yards161193
Completions18/2923/32
Yards per pass5.46.0
Interceptions thrown23
Sacks allowed1-80-0
Rushing yards69147
Rushing attempts1338
Yards per rush5.33.9
Red zone trips0-22-3
Penalties4-302-6
Turnovers23
Fumbles lost00
Defensive touchdowns00
Time of possession22:1837:42

Win probability

Above the line favours San Francisco 49ers, below favours Carolina Panthers.

Venue

  • Levi's StadiumSanta Clara, CA
  • Attendance71337
  • OfficialsRusty Baynes, Sean Petty, Scott Helverson, Alex Kemp, Mike Carr, Lo van Pham, Brandon Ellison

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.