Twins Defeat Guardians 6-2 at Target Field
Sunday, September 21, 2025, 2:10 PM ET · Target Field
Minnesota Twins 6, Cleveland Guardians 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won Cleveland Guardians vs Minnesota Twins?
Minnesota Twins beat Cleveland Guardians 6-2 at Target Field on September 21, 2025.
In a decisive victory, the Minnesota Twins triumphed over the Cleveland Guardians with a final score of 6-2 at Target Field. This win not only showcased the Twins' ability to bounce back after a tough series but also marked a significant moment in their season, as they faced a Cleveland team that had recently dominated their matchups. The Guardians had won the series 4-2 against the Twins leading up to this game, making this victory particularly noteworthy for Minnesota.
Entering this matchup, the Twins had struggled in their recent form, holding a record of 4-6 over their last ten games and currently on a three-game losing streak. Their average runs scored during this stretch was 5.7, while they allowed an average of 6.7 runs per game. In contrast, the Guardians were riding a hot streak, boasting a record of 9-1 in their last ten games, with an impressive eight-game winning streak. Cleveland's average runs scored during this period was 3.8, and they allowed just 1.7 runs per game, highlighting their strong pitching and defensive performance.
Home and away records further illustrated the contrasting fortunes of the two teams. The Twins had a home record of 2-4 in their last six games at Target Field, while the Guardians had excelled with a 5-1 record in their last six away games. This game was crucial for the Twins as they aimed to improve their standing amidst a challenging season, with a current overall record of 67-89 compared to the Guardians' 84-72.
In terms of previous meetings, the Twins had faced the Guardians multiple times this season, with the most recent encounter prior to this game resulting in a 6-2 loss for Minnesota just a day earlier on September 20, 2025. This history added an extra layer of intensity to the matchup, as the Twins sought to avenge their recent defeat.
Injuries played a significant role in both teams' lineups. The Twins were without key players, including Byron Buxton, who was on the 10-Day IL due to a hip injury, and Joe Ryan, who was on the 15-Day IL with a lower body issue. Austin Martin and Mike Paredes were also sidelined, adding to the Twins' challenges. The Guardians were not without their own injury concerns, as Slade Cecconi and Rhys Hoskins were both on the 15-Day IL, while Shawn Armstrong was on the 60-Day IL due to a calf injury.
The market had priced the Twins as the favorites for this game, reflecting a home-field advantage, with odds attributed to the provider indicating a strong belief in their potential to secure the win. The conditions at Target Field were favorable for baseball, allowing for a competitive atmosphere as the teams took the field.
As the game unfolded, the scoring plays were pivotal in determining the outcome. The Guardians struck first in the 1st inning when Steven Kwan homered to right field, followed by a sacrifice fly from Josh Naylor that brought in another run, giving Cleveland an early 2-0 lead. However, the Twins responded in the 3rd inning with a single from Clemens that allowed Buxton to score, narrowing the gap to 2-1.
The turning point came in the 6th inning when the Twins took the lead for the first time, with Lee hitting a homer to right center, scoring Keaschall. The 7th inning saw the Twins extend their lead significantly when Lewis homered to left center, bringing in both Clemens and Martin to score, ultimately leading to a 6-2 advantage.
The final score reflected the Twins' resilience and ability to capitalize on their opportunities, while the Guardians were left to regroup after a strong start that ultimately fizzled out. This victory was a much-needed boost for the Twins as they look to finish the season on a high note.
Injury report
- Byron Buxton10-Day-ILHipMinnesota Twins
- Joe Ryan15-Day-ILLower BodyMinnesota Twins
- Austin Martin10-Day-ILHamstringMinnesota Twins
- Mike Paredes60-Day-ILObliqueMinnesota Twins
- Mick Abel60-Day-ILElbowMinnesota Twins
- Slade Cecconi15-Day-ILArmCleveland Guardians
- Rhys Hoskins10-Day-ILBackCleveland Guardians
- Shawn Armstrong60-Day-ILCalfCleveland Guardians
Recent form
Minnesota Twins
Last 10: 4-6Streak L35.7 scored · 6.7 allowed per game2-4 at home
- L2-6vs Cleveland GuardiansSep 20
- L5-10vs New York YankeesSep 17
- L9-10vs New York YankeesSep 16
- W7-0vs New York YankeesSep 15
- L4-6vs Arizona DiamondbacksSep 14
- W9-8vs Arizona DiamondbacksSep 13
- L2-12at Los Angeles AngelsSep 10
- W12-3at Los Angeles AngelsSep 9
- W5-1at Kansas City RoyalsSep 7
- L2-11at Kansas City RoyalsSep 6
Cleveland Guardians
Last 10: 9-1Streak W83.8 scored · 1.7 allowed per game4-0 away
- W6-2at Minnesota TwinsSep 20
- W3-1at Detroit TigersSep 18
- W4-0at Detroit TigersSep 17
- W7-5at Detroit TigersSep 16
- W3-2vs Chicago White SoxSep 14
- W3-1vs Chicago White SoxSep 13
- W4-0vs Chicago White SoxSep 12
- W3-2vs Kansas City RoyalsSep 11
- L3-4vs Kansas City RoyalsSep 10
- W2-0vs Kansas City RoyalsSep 9
Standings
| Team | Games behind | Lost | Streak | Win % | Won |
|---|---|---|---|---|---|
| Chicago | - | 66 | L1 | .525 | 73 |
| Cleveland | 3 | 69 | L1 | .504 | 70 |
| Minnesota | 6.5 | 73 | L1 | .479 | 67 |
| Detroit | 9 | 75 | W1 | .460 | 64 |
| Kansas City | 11.5 | 78 | L3 | .443 | 62 |
How the scoring went
- 1st Inning1-0Kwan homered to right (373 feet).
- 1st Inning2-0Naylor hit sacrifice fly to center, Valera scored.
- 3rd Inning2-1Clemens singled to left, Buxton scored.
- 6th Inning2-3Lee homered to right center (411 feet), Keaschall scored.
- 7th Inning2-6Lewis homered to left center (402 feet), Clemens scored and Martin scored.
Win probability
Above the line favours Minnesota Twins, below favours Cleveland Guardians.
Venue
- Target FieldMinneapolis, Minnesota
- Attendance22526
- OfficialsNick Mahrley, Vic Carapazza, Mark Ripperger, Jacob Metz
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These two, other days
- Cleveland Guardians Defeat Minnesota Twins 9-2Sep 13, 2026
- Twins Edge Guardians in Close ContestSep 12, 2026
- Cleveland Guardians Defeat Minnesota Twins 5-2Sep 11, 2026
- Twins Triumph Over Guardians in Extra InningsJul 23, 2026
- Twins Outlast Guardians in High-Scoring AffairJul 22, 2026