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MLB · Final

Twins Outlast Guardians in High-Scoring Affair

Wednesday, July 22, 2026, 6:40 PM ET · Progressive Field

Minnesota Twins 10, Cleveland Guardians 6, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Minnesota Twins vs Cleveland Guardians?

Minnesota Twins beat Cleveland Guardians 10-6 at Progressive Field on July 22, 2026.

Who was favored in Minnesota Twins vs Cleveland Guardians?

Cleveland Guardians were the favorite at DraftKings, moneyline -137 (about 58% implied). The underdog won.

In a thrilling contest at Progressive Field, the Minnesota Twins triumphed over the Cleveland Guardians with a final score of 10-6. This victory allowed the Twins to take the series lead, now sitting at 3-2 against the Guardians in their recent matchups.

The Guardians entered this game with a home record of 54-49, showcasing a solid performance in their last ten games, where they recorded a 6-3-1 record and were riding a two-game winning streak. They averaged 4.2 runs scored per game while allowing only 3.3 runs during this stretch. Their recent victories included a 5-2 win over the Twins just a day prior, as well as a commanding 13-4 victory against the same team on July 20. However, their home record in the last five games stood at 2-2, indicating some inconsistency despite their overall strong performance.

On the other hand, the Minnesota Twins, with an away record of 50-53, have struggled recently, losing their last three games and posting a 5-5 record over their last ten. They averaged 3.6 runs scored per game while allowing 4.8 runs, which highlights their defensive vulnerabilities. Their last five games reflected a troubling trend, as they averaged just 3.2 runs scored while giving up 6.4 runs, underscoring their struggles on the road.

The injury situation for both teams played a role in the matchup. The Guardians were missing Slade Cecconi (15-Day-IL, arm), Rhys Hoskins (10-Day-IL, back), and Shawn Armstrong (60-Day-IL, calf). The Twins had their own challenges, with Byron Buxton (10-Day-IL, hip), Joe Ryan (15-Day-IL, lower body), Austin Martin (10-Day-IL, hamstring), Mike Paredes (60-Day-IL, oblique), and Mick Abel (60-Day-IL, elbow) all sidelined.

The betting odds from DraftKings indicated a slight favor towards the Guardians at -137, with a spread of -1.5 and a total set at 8.0 runs. The odds for the over were -109.0, while the under sat at -111.0, reflecting a competitive matchup expected to yield a decent number of runs.

As the game unfolded, the scoring began in the third inning when Bell grounded out, allowing Larnach to score. The Twins took a 4-3 lead in the fourth inning with Jackson's infield single, followed by Lee's impressive 401-foot homer that brought in two more runs. The Guardians responded with a run of their own, narrowing the gap to 7-4.

The Twins extended their lead in the eighth inning with Larnach's two-run single and Bell's subsequent single, pushing the score to 10-4. The Guardians attempted a comeback in the ninth, with Manzardo hitting a homer and another single bringing their total to six runs, but it was not enough to overcome the Twins' lead.

The game showcased the offensive capabilities of both teams, with the Twins capitalizing on their opportunities and the Guardians fighting back but ultimately falling short. This matchup highlighted the ongoing rivalry between the two teams, with the series now favoring the Twins as they look to build on this momentum.

Odds

BookSpreadTotalMoneyline
DraftKingsCLE -137 8 o -109 / u -111 Minnesota Twins +114 · Cleveland Guardians -137

What these prices pay on $100 · What these numbers mean

Injury report

  • Slade Cecconi15-Day-ILArmCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians
  • Byron Buxton10-Day-ILHipMinnesota Twins
  • Joe Ryan15-Day-ILLower BodyMinnesota Twins
  • Austin Martin10-Day-ILHamstringMinnesota Twins
  • Mike Paredes60-Day-ILObliqueMinnesota Twins
  • Mick Abel60-Day-ILElbowMinnesota Twins

Recent form

Cleveland Guardians

Last 10: 6-3-1Streak W24.2 scored · 3.3 allowed per game2-2 at home

  • W5-2vs Minnesota TwinsJul 21
  • W13-4vs Minnesota TwinsJul 20
  • L1-7vs Pittsburgh PiratesJul 19
  • L1-7vs Pittsburgh PiratesJul 18
  • D0-0vs Pittsburgh PiratesJul 17
  • W5-2at Miami MarlinsJul 12
  • W4-1at Miami MarlinsJul 11
  • W3-2at Miami MarlinsJul 10
  • W5-2at Minnesota TwinsJul 9
  • L5-6at Minnesota TwinsJul 8

Minnesota Twins

Last 10: 5-5Streak L33.6 scored · 4.8 allowed per game2-3 away

  • L2-5at Cleveland GuardiansJul 21
  • L4-13at Cleveland GuardiansJul 20
  • L1-10at Chicago CubsJul 19
  • W5-2at Chicago CubsJul 18
  • W4-2vs Los Angeles AngelsJul 12
  • L3-4vs Los Angeles AngelsJul 11
  • L2-5vs Cleveland GuardiansJul 9
  • W6-5vs Cleveland GuardiansJul 8
  • W3-1vs Cleveland GuardiansJul 7
  • W6-1at New York YankeesJul 5

Standings

TeamGames behindLostStreakWin %Won
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362

How the scoring went

  1. 1st Inning1-0Larnach homered to right center (404 feet).
  2. 1st Inning1-1Rocchio singled to left, Ramírez scored.
  3. 2nd Inning1-2Bailey singled to right, Manzardo scored.
  4. 2nd Inning1-3Ramírez reached on infield single to third, Bailey scored, Kwan to second.
  5. 3rd Inning2-3Lee singled to center, Jackson scored, Larnach to third.
  6. 3rd Inning3-3Bell grounded out to second, Larnach scored, Lee to second.
  7. 4th Inning4-3Jackson reached on infield single to third, Roden scored, Keaschall to second.
  8. 4th Inning7-3Lee homered to center (401 feet), Keaschall and Jackson scored.
  9. 4th Inning7-4Ramírez grounded into fielder's choice to second, Halpin scored, Kwan out at second.
  10. 8th Inning9-4Larnach singled to center, Keaschall scored and Roden scored, Jackson to second.
  11. 8th Inning10-4Bell singled to center, Jackson scored, Larnach to second.
  12. 8th Inning10-5Manzardo homered to right (344 feet).
  13. 9th Inning10-6Manzardo singled to right, Rocchio scored.

Win probability

Above the line favours Cleveland Guardians, below favours Minnesota Twins.

Venue

  • Progressive FieldCleveland, Ohio
  • Attendance22807
  • OfficialsWillie Traynor, Charlie Ramos, David Rackley, Nestor Ceja

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.