Lions Dominate Cardinals in Convincing Win
Sunday, October 11, 2026, 4:25 PM ET · State Farm Stadium
Detroit Lions 45, Arizona Cardinals 21, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won Detroit Lions vs Arizona Cardinals?
Detroit Lions beat Arizona Cardinals 45-21 at State Farm Stadium on October 11, 2026.
Who was favored in Detroit Lions vs Arizona Cardinals?
Detroit Lions were the favorite at DraftKings, moneyline -245 (about 71% implied). The favorite won.
In a decisive matchup at State Farm Stadium, the Detroit Lions triumphed over the Arizona Cardinals with a final score of 45-21. The Lions, now boasting a 4-2 record, showcased their offensive prowess, while the Cardinals fell to 1-5, continuing their struggles this season.
The Lions entered the game with a recent record of 4-6 over their last ten games, averaging 27.4 points scored and allowing 29.7 points. They had a mixed bag of results leading up to this game, including a loss to the Carolina Panthers just one week prior. However, their ability to score consistently has kept them competitive, as seen in their recent performances. In contrast, the Cardinals have been in a downward spiral, holding a record of 1-9 over their last ten games, with an average of 19.4 points scored and a staggering 32.2 points allowed. This marked their third consecutive loss, reflecting a troubling trend for the team.
At home, the Cardinals have struggled significantly, with a home record of 0-3 this season. Their only victory this year came on the road against the Los Angeles Chargers. The Lions, on the other hand, have performed better away, with a 3-2 record on the road, showcasing their ability to compete in hostile environments.
In terms of previous meetings, the Lions and Cardinals have faced off multiple times, but the recent trend has favored the Lions, who have consistently found ways to outscore the Cardinals. This game continued that trend, as the Lions dominated both offensively and defensively.
Injuries played a role in the game, particularly for the Cardinals, who were missing several key players. Wydett Williams Jr. was listed as questionable due to a concussion, while Carson Beck, Starling Thomas V, Andrew Wingard, and Andrew Billings were all ruled out for various reasons. The Lions also had their share of injury concerns, with Devin White and Tom Kennedy both listed as questionable, and Jackson Meeks, Mekhi Wingo, and Rock Ya-Sin ruled out.
The betting market, provided by DraftKings, had the Lions favored by 4.5 points, with a total set at 55.5. The odds reflected the Lions' stronger form and the Cardinals' struggles, indicating a clear expectation of a Lions victory.
Conditions on game day were typical for a fall evening in Arizona, with clear skies and a temperature conducive to football, allowing both teams to execute their game plans effectively.
Viewers were treated to a showcase of the Lions' offensive capabilities, as they displayed a balanced attack that kept the Cardinals' defense on their heels. The Cardinals, despite their struggles, managed to put up 21 points, but it was not enough to keep pace with the Lions, who capitalized on their opportunities and maintained control throughout the game.
What we said beforehand
The upcoming matchup between the Arizona Cardinals and the Detroit Lions at State Farm Stadium promises to be a compelling contest, particularly given the Cardinals' struggles this season. Currently, the Cardinals hold a home record of 1-3, while the Lions have fared slightly better with an away record of 2-2. This game, scheduled for October 11, 2026, at 20:25 UTC, will be crucial for both teams as they seek to improve their standings in the NFL.
The Cardinals have faced a challenging stretch, losing their last three games. Their recent results include a 36-24 loss to the New York Giants, a 36-30 defeat against the San Francisco 49ers, and a 31-7 loss to the Seattle Seahawks. Over their last five games, they have managed just one victory, which came against the Los Angeles Chargers (26-14). On average, the Cardinals have scored 21.4 points while allowing 30.8 points in their last five outings. Their overall performance at home has been particularly concerning, with an average of 19.4 points scored and 32.2 points allowed over their last ten home games.
In contrast, the Lions have shown a more balanced performance, with a record of 3-2 in their last five games. They recently lost to the Carolina Panthers (32-26) but secured victories against the New York Jets (31-24) and the New Orleans Saints (31-30 OT). The Lions have averaged 27.6 points scored and allowed 28.6 points in their last five games, indicating a tendency for high-scoring affairs. Their away record of 2-2 suggests they have been competitive on the road, although they have also faced challenges, particularly in their last outing.
Historically, the Cardinals have struggled at home, with a recent record of 1-9 in their last ten home games. This includes a streak of three consecutive losses at home, which could weigh heavily on their confidence as they prepare to face the Lions. The Lions, on the other hand, have had a more favorable record on the road, suggesting they might be able to capitalize on the Cardinals' vulnerabilities.
In terms of injuries, the Cardinals will be missing several key players, including Carson Beck, Starling Thomas V, Andrew Wingard, Marvin Harrison Jr., and Andrew Billings, all ruled out due to various reasons, including coach's decisions and injury. The Lions will also be without Jackson Meeks, Mekhi Wingo, Rock Ya-Sin (hamstring), Ahmed Hassanein, and Bishop Fitzgerald, all out for coach's decisions. The absence of these players could significantly impact both teams' strategies and performances.
The betting market has set the Lions as 5.5-point favorites according to DraftKings, with a total points line of 55.5 for the game. This indicates expectations of a relatively high-scoring matchup, reflecting both teams' recent offensive outputs.
Weather conditions for the game are expected to be warm, with a temperature around 87°F. There is a 61% chance of precipitation, and gusts could reach up to 25 mph. These conditions may influence the style of play, particularly in terms of passing and kicking games.
Viewers should watch for the performance of the Lions' quarterback Jared Goff, who has thrown for 1,214 yards and nine touchdowns this season. His ability to connect with star receiver Amon-Ra St. Brown, who has 303 receiving yards and five touchdowns, will be crucial. For the Cardinals, Jacoby Brissett leads the team with 818 passing yards and six touchdowns, while Michael Wilson has been a key target with 258 receiving yards and one touchdown. The effectiveness of the Cardinals' rushing game, led by Jeremiyah Love with 223 rushing yards and one touchdown, will also be a focal point as they look to establish a balanced attack.
As both teams prepare for this pivotal clash, the stakes are high, and the outcome could significantly affect their respective seasons.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | DET -4.5 | 55.5 o -110 / u -110 | Detroit Lions -245 · Arizona Cardinals +200 |
Injury report
- Wydett Williams Jr.QuestionableConcussionArizona Cardinals
- Carson BeckOutCoach's DecisionArizona Cardinals
- Starling Thomas VOutCoach's DecisionArizona Cardinals
- Andrew WingardOutKneeArizona Cardinals
- Andrew BillingsOutCoach's DecisionArizona Cardinals
- Devin WhiteQuestionableForearmDetroit Lions
- Tom KennedyQuestionableKneeDetroit Lions
- Jackson MeeksOutCoach's DecisionDetroit Lions
- Mekhi WingoOutCoach's DecisionDetroit Lions
- Rock Ya-SinOutHamstringDetroit Lions
Leaders
- Passing yardsJacoby Brissett29/47, 292 YDS, 3 TD, 1 INTArizona Cardinals
- Rushing yardsJeremiyah Love12 CAR, 22 YDSArizona Cardinals
- Receiving yardsKendrick Bourne5 REC, 70 YDSArizona Cardinals
- Passing yardsJared Goff19/30, 271 YDS, 3 TDDetroit Lions
- Rushing yardsJahmyr Gibbs25 CAR, 151 YDS, 2 TDDetroit Lions
- Receiving yardsSam LaPorta5 REC, 88 YDS, 1 TDDetroit Lions
Recent form
Arizona Cardinals
Last 10: 1-9Streak L319.4 scored · 32.2 allowed per game0-3 at home
- L24-36at New York GiantsOct 4
- L30-36at San Francisco 49ersSep 27
- L7-31vs Seattle SeahawksSep 20
- W26-14at Los Angeles ChargersSep 13
- L20-37at Los Angeles RamsJan 4
- L14-37at Cincinnati BengalsDec 28
- L19-26vs Atlanta FalconsDec 21
- L20-40at Houston TexansDec 14
- L17-45vs Los Angeles RamsDec 7
- L17-20at Tampa Bay BuccaneersNov 30
Detroit Lions
Last 10: 4-6Streak L127.4 scored · 29.7 allowed per game1-4 away
- L26-32at Carolina PanthersOct 5
- W31-24vs New York JetsSep 27
- L31-41at Buffalo BillsSep 18
- W31-30vs New Orleans SaintsSep 13
- W19-16at Chicago BearsJan 4
- L10-23at Minnesota VikingsDec 25
- L24-29vs Pittsburgh SteelersDec 21
- L34-41at Los Angeles RamsDec 14
- W44-30vs Dallas CowboysDec 5
- L24-31vs Green Bay PackersNov 27
Standings
| Team | Lost | Points against | Points for | Tied | Win % | Won | Overall |
|---|---|---|---|---|---|---|---|
| Minnesota | 0 | 64 | 109 | 0 | 1.000 | 5 | 5-0 |
| Green Bay | 2 | 112 | 104 | 0 | .600 | 3 | 3-2 |
| Chicago | 2 | 96 | 119 | 0 | .600 | 3 | 3-2 |
| Detroit | 2 | 148 | 164 | 0 | .600 | 3 | 3-2 |
| San Francisco | 0 | 93 | 154 | 0 | 1.000 | 5 | 5-0 |
| Seattle | 2 | 105 | 134 | 0 | .600 | 3 | 3-2 |
| Los Angeles | 2 | 83 | 85 | 0 | .500 | 2 | 2-2 |
| Arizona | 4 | 162 | 108 | 0 | .200 | 1 | 1-4 |
Box score
| Stat | Detroit Lions | Arizona Cardinals |
|---|---|---|
| First downs | 24 | 20 |
| First downs passing | 12 | 17 |
| First downs rushing | 10 | 2 |
| First downs by penalty | 2 | 1 |
| Third downs | 4-13 | 8-18 |
| Fourth downs | 4-4 | 2-3 |
| Offensive plays | 65 | 71 |
| Total yards | 412 | 327 |
| Yards per play | 6.3 | 4.6 |
| Drives | 11 | 12 |
| Net passing yards | 249 | 271 |
| Completions | 19/30 | 30/48 |
| Yards per pass | 7.5 | 5.1 |
| Interceptions thrown | 0 | 1 |
| Sacks allowed | 3-22 | 5-28 |
| Rushing yards | 163 | 56 |
| Rushing attempts | 32 | 18 |
| Yards per rush | 5.1 | 3.1 |
| Red zone trips | 4-4 | 3-4 |
| Penalties | 4-31 | 5-45 |
| Turnovers | 0 | 1 |
| Fumbles lost | 0 | 0 |
| Defensive touchdowns | 0 | 0 |
| Time of possession | 29:49 | 30:11 |
Win probability
Above the line favours Arizona Cardinals, below favours Detroit Lions.
Venue
- State Farm StadiumGlendale, AZ
- Attendance60968
- OfficialsDerick Bowers, Carl Cheffers, Martin Hankins, Nathan Jones, Dominique Pender, Derek Anderson, Quentin Givens
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