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NFL · Final

Bills Edge Lions in High-Scoring Showdown

Thursday, September 17, 2026, 8:15 PM ET · Highmark Stadium

Quick answers

Who won Detroit Lions vs Buffalo Bills?

Buffalo Bills beat Detroit Lions 41-31 at Highmark Stadium on September 17, 2026.

Who was favored in Detroit Lions vs Buffalo Bills?

Buffalo Bills were the favorite at DraftKings, moneyline -245 (about 71% implied). The favorite won.

In an electrifying matchup at Highmark Stadium, the Buffalo Bills triumphed over the Detroit Lions with a final score of 41-31. This victory solidifies the Bills' strong start to the season, improving their home record to 3-1 and extending their winning streak to two games. The game showcased a high-scoring affair, reflecting both teams' offensive capabilities.

The Bills entered the game with a home record of 2-0 and a recent form of 7-3 over their last ten games, averaging 28.2 points scored per game while allowing 22.9. Their last five games saw them achieving an impressive average of 28.2 points scored and 20.6 points allowed. In contrast, the Lions, with an away record of 1-1, had a more balanced recent form, holding a 5-5 record over their last ten games with an average of 27.3 points scored and 26.5 points allowed. They also came into the game riding a two-game winning streak, having recently defeated the New Orleans Saints 31-30.

The matchup was particularly significant given the teams' contrasting performances at home and away. The Bills have been dominant at home, while the Lions have struggled to find consistency on the road. Previous meetings between these two teams have often been competitive, but this game was marked by a significant offensive display from both sides.

In terms of injuries, the Bills faced several challenges, with DJ Moore listed as questionable due to a shoulder injury, and key players such as T.J. Sanders, Ed Oliver, and Ty Johnson ruled out for the game. The Lions also had notable absences, including Mekhi Wingo and Jimmy Rolder, both out due to coach's decisions, while Avonte Maddox was questionable with a foot injury.

The betting market, as provided by DraftKings, had the Bills favored with a spread of -5.5 and a total set at 54.5. The odds reflected confidence in the Bills' ability to secure a victory at home, with a moneyline of -245 for the Bills and +200 for the Lions.

Conditions at Highmark Stadium were conducive to scoring, which was evident in the final score. The game featured a fast pace and explosive plays, making it a thrilling spectacle for fans. Viewers were treated to a showcase of offensive talent, with both teams displaying their ability to move the ball effectively.

Overall, the Bills' victory not only highlights their strong home performance but also sets a tone for the remainder of the season as they continue to build momentum.

What we said beforehand

The upcoming matchup between the Buffalo Bills and the Detroit Lions at Highmark Stadium promises to be an exciting encounter, with both teams entering the game with a 1-0 record this season. The Bills are coming off a narrow victory against the Houston Texans, winning 36-31, while the Lions edged out the New Orleans Saints in a thrilling 31-30 overtime win. This game will not only showcase the talents of both teams but also highlight their respective strengths and weaknesses as they look to build momentum early in the season.

The Buffalo Bills have displayed a strong offensive performance in their recent outings, averaging 28.2 points per game over their last five games, while allowing an average of 20.6 points. Their most recent game saw quarterback Josh Allen throw for 334 yards and 2 touchdowns against the Texans, highlighting his ability to lead the offense effectively. The Bills have a solid home record of 3-1 in their last four games at Highmark Stadium, and they are currently on a two-game winning streak.

On the other hand, the Detroit Lions have also shown promise, averaging 27.3 points scored per game over their last ten contests, although they have allowed an average of 26.5 points. Their recent win against the Saints featured quarterback Jared Goff passing for 206 yards and 2 touchdowns, while running back Jahmyr Gibbs had an impressive outing with 156 rushing yards and 2 touchdowns. The Lions have a mixed away record of 2-3, but they are also riding a two-game winning streak, which adds to the intrigue of this matchup.

In terms of injuries, the Bills will be without several key players, including Skyler Bell, T.J. Sanders, Ed Oliver, Ty Johnson, and Ar'maj Reed-Adams, all of whom are out due to various reasons, including coach's decisions and injuries. The Lions will also be missing Mekhi Wingo, Ennis Rakestraw Jr., Jimmy Rolder, Ahmed Hassanein, and Keith Abney II, all out due to coach's decisions. The absence of these players could significantly impact both teams' strategies and depth.

Weather conditions for the game are expected to be mostly cloudy with a temperature around 67°F. There is a 100% chance of precipitation, which could potentially affect the gameplay, particularly in terms of passing and kicking. Wind gusts are expected to be mild at 3 mph, which should not significantly influence the game.

The betting market has set the Bills as 5.5-point favorites, according to DraftKings, with a total points line of 54.5. The odds reflect a competitive matchup, and the spread indicates that the Bills are expected to win by over a field goal. The moneyline odds show the Bills at -238, while the Lions are positioned at +195, suggesting that the Bills are favored to secure a victory.

As the game approaches, viewers should watch for the performance of both quarterbacks, Allen and Goff, as they look to lead their respective offenses. Additionally, the effectiveness of the running games, particularly with Gibbs for the Lions and James Cook III for the Bills, will be crucial in determining the outcome of the contest. With both teams looking to establish their presence early in the season, this matchup is set to be a thrilling display of NFL action.

Odds

BookSpreadTotalMoneyline
DraftKingsBUF -5.5 54.5 o -118 / u -102 Detroit Lions +200 · Buffalo Bills -245

What these prices pay on $100 · What these numbers mean

Injury report

  • DJ MooreQuestionableShoulderBuffalo Bills
  • Skyler BellOutCoach's DecisionBuffalo Bills
  • T.J. SandersOutKneeBuffalo Bills
  • Ed OliverOutHipBuffalo Bills
  • Ty JohnsonOutHamstringBuffalo Bills
  • Avonte MaddoxQuestionableFootDetroit Lions
  • Mekhi WingoOutCoach's DecisionDetroit Lions
  • Ennis Rakestraw Jr.OutCoach's DecisionDetroit Lions
  • Jimmy RolderOutCoach's DecisionDetroit Lions
  • Ahmed HassaneinOutCoach's DecisionDetroit Lions

Leaders

  • Passing yardsJosh Allen20/31, 248 YDS, 3 TDBuffalo Bills
  • Rushing yardsJames Cook III21 CAR, 135 YDS, 1 TDBuffalo Bills
  • Receiving yardsDalton Kincaid7 REC, 95 YDS, 1 TDBuffalo Bills
  • Passing yardsJared Goff26/38, 327 YDS, 4 TDDetroit Lions
  • Rushing yardsJahmyr Gibbs16 CAR, 52 YDSDetroit Lions
  • Receiving yardsAmon-Ra St. Brown9 REC, 142 YDS, 2 TDDetroit Lions

Recent form

Buffalo Bills

Last 10: 7-3Streak W228.2 scored · 22.9 allowed per game3-1 at home

  • W36-31at Houston TexansSep 13
  • W35-8vs New York JetsJan 4
  • L12-13vs Philadelphia EaglesDec 28
  • W23-20at Cleveland BrownsDec 21
  • W35-31at New England PatriotsDec 14
  • W39-34vs Cincinnati BengalsDec 7
  • W26-7at Pittsburgh SteelersNov 30
  • L19-23at Houston TexansNov 21
  • W44-32vs Tampa Bay BuccaneersNov 16
  • L13-30at Miami DolphinsNov 9

Detroit Lions

Last 10: 5-5Streak W227.3 scored · 26.5 allowed per game2-3 away

  • W31-30vs New Orleans SaintsSep 13
  • W19-16at Chicago BearsJan 4
  • L10-23at Minnesota VikingsDec 25
  • L24-29vs Pittsburgh SteelersDec 21
  • L34-41at Los Angeles RamsDec 14
  • W44-30vs Dallas CowboysDec 5
  • L24-31vs Green Bay PackersNov 27
  • W34-27vs New York GiantsNov 23
  • L9-16at Philadelphia EaglesNov 17
  • W44-22at Washington CommandersNov 9

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Minnesota0223901.00011-0
Chicago0375901.00011-0
Detroit171620.50011-1
Green Bay139220.00000-1
Buffalo0627701.00022-0
New York0102301.00011-0
Miami127130.00000-1
New England113100.00000-1

Box score

StatDetroit LionsBuffalo Bills
First downs2434
First downs passing1914
First downs rushing215
First downs by penalty35
Third downs4-119-12
Fourth downs2-20-0
Offensive plays6269
Total yards355446
Yards per play5.76.5
Drives99
Net passing yards289243
Completions26/3820/31
Yards per pass6.97.4
Interceptions thrown00
Sacks allowed4-382-5
Rushing yards66203
Rushing attempts2036
Yards per rush3.35.6
Red zone trips3-45-5
Penalties10-585-46
Turnovers00
Fumbles lost00
Defensive touchdowns00
Time of possession26:1533:45

Win probability

Above the line favours Buffalo Bills, below favours Detroit Lions.

Venue

  • Highmark StadiumOrchard Park, NY
  • Attendance60644
  • OfficialsDerick Bowers, Ronald Torbert, Keith Washington, Roy Ellison, Ryan Dickson, Thomas Eaton, Courtney Brown

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.