ENSign in
NFL · Final

Jaguars Edge 49ers in Thrilling Finish

Sunday, September 28, 2025, 4:05 PM ET · Levi's Stadium

Jacksonville Jaguars 26, San Francisco 49ers 21, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

Next free pick (not the main pick)

The next free pick, for your email

Team, bet, price and the hash it was sealed under, on this page the moment you send. Lose or win, it stays public.

Unlock today's pick in Telegram →

or by email

Public record of the main pick, losses included: 115 won, 44 lost. See every pick

One free pick a day by email until you unsubscribe, in one click. 21+.

Get the daily free pick · See plans

Quick answers

Who won Jacksonville Jaguars vs San Francisco 49ers?

Jacksonville Jaguars beat San Francisco 49ers 26-21 at Levi's Stadium on September 28, 2025.

In a closely contested matchup at Levi's Stadium, the Jacksonville Jaguars defeated the San Francisco 49ers with a final score of 26-21. Both teams entered the game with a 3-1 record, making this clash significant as they sought to solidify their positions in the NFL standings. The Jaguars, riding a one-game winning streak, managed to outlast the 49ers, who were on a three-game winning streak, showcasing a thrilling back-and-forth battle.

The 49ers' recent form has been mixed, with a record of 4-6 over their last ten games, but they had shown improvement with their current three-game winning streak. Their scoring average during this stretch was 19.8 points per game, while they allowed an average of 26.3 points. In their last five games, the 49ers had a record of 3-2, averaging 23.4 points scored and 27.2 points allowed. At home, they had a record of 2-2, indicating their struggles to maintain dominance at Levi's Stadium.

Conversely, the Jaguars also recorded a 4-6 mark over their last ten games, with their latest victory snapping a streak of inconsistency. They averaged 18.8 points scored and allowed 22.2 points during this period. Their recent form showed signs of life with a 3-2 record in the last five games, where they averaged 22.6 points scored and only 18.0 points allowed. However, their away record of 1-4 highlighted their difficulties outside of Jacksonville.

In terms of previous meetings, this matchup was crucial as both teams aimed to establish a psychological edge. The injury report was significant, particularly for the 49ers, who had several key players listed as questionable, including Sam Okuayinonu (foot), Kyle Juszczyk (finger), Nick Bosa (knee - ACL), Mike Evans (groin), and George Kittle (Achilles). The Jaguars had LeQuint Allen Jr. (undisclosed), Bhayshul Tuten (illness), and Jakobi Meyers (hand) also listed as questionable, while Keivie Rose (undisclosed) and Carter Bradley (thumb) were on injured reserve.

The market had priced the 49ers as underdogs in this matchup, with a home win probability of 0.0, indicating a strong expectation for the Jaguars to come away with the victory. The game conditions were typical for a late September evening in California, with no significant weather disruptions reported.

Viewers were treated to a game that showcased the resilience of both teams, with the Jaguars ultimately prevailing. The final score of 26-21 reflects the competitive nature of the matchup, with the Jaguars managing to execute crucial plays down the stretch to secure the win.

Injury report

  • Sam OkuayinonuQuestionableFootSan Francisco 49ers
  • Kyle JuszczykQuestionableFingerSan Francisco 49ers
  • Nick BosaQuestionableKnee - ACLSan Francisco 49ers
  • Mike EvansQuestionableGroinSan Francisco 49ers
  • George KittleQuestionableAchillesSan Francisco 49ers
  • LeQuint Allen Jr.QuestionableUndisclosedJacksonville Jaguars
  • Bhayshul TutenQuestionableIllnessJacksonville Jaguars
  • Jakobi MeyersQuestionableHandJacksonville Jaguars
  • Keivie RoseInjured ReserveUndisclosedJacksonville Jaguars
  • Carter BradleyInjured ReserveThumbJacksonville Jaguars

Leaders

  • Passing yardsBrock Purdy22/38, 309 YDS, 2 TD, 2 INTSan Francisco 49ers
  • Rushing yardsChristian McCaffrey17 CAR, 49 YDSSan Francisco 49ers
  • Receiving yardsChristian McCaffrey6 REC, 92 YDS, 1 TDSan Francisco 49ers
  • Passing yardsTrevor Lawrence21/31, 174 YDS, 1 TDJacksonville Jaguars
  • Rushing yardsTravis Etienne Jr.19 CAR, 124 YDS, 1 TDJacksonville Jaguars
  • Receiving yardsBrian Thomas Jr.5 REC, 49 YDSJacksonville Jaguars

Recent form

San Francisco 49ers

Last 10: 4-6Streak W319.8 scored · 26.3 allowed per game2-2 at home

  • W16-15vs Arizona CardinalsSep 21
  • W26-21at New Orleans SaintsSep 14
  • W17-13at Seattle SeahawksSep 7
  • L24-47at Arizona CardinalsJan 5
  • L34-40vs Detroit LionsDec 31
  • L17-29at Miami DolphinsDec 22
  • L6-12vs Los Angeles RamsDec 13
  • W38-13vs Chicago BearsDec 8
  • L10-35at Buffalo BillsDec 2
  • L10-38at Green Bay PackersNov 24

Jacksonville Jaguars

Last 10: 4-6Streak W118.8 scored · 22.2 allowed per game1-4 away

  • W17-10vs Houston TexansSep 21
  • L27-31at Cincinnati BengalsSep 14
  • W26-10vs Carolina PanthersSep 7
  • L23-26at Indianapolis ColtsJan 5
  • W20-13vs Tennessee TitansDec 29
  • L14-19at Las Vegas RaidersDec 22
  • L25-32vs New York JetsDec 15
  • W10-6at Tennessee TitansDec 8
  • L20-23vs Houston TexansDec 1
  • L6-52at Detroit LionsNov 17

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Jacksonville154600.66722-1
Tennessee153530.66722-1
Indianapolis272351.16700-2-1
Houston365400.00000-3
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1

Box score

StatJacksonville JaguarsSan Francisco 49ers
First downs1822
First downs passing817
First downs rushing83
First downs by penalty22
Third downs4-148-13
Fourth downs1-10-1
Offensive plays6363
Total yards325389
Yards per play5.26.2
Drives1111
Net passing yards174306
Completions21/3122/38
Yards per pass5.67.8
Interceptions thrown02
Sacks allowed0-01-3
Rushing yards15183
Rushing attempts3224
Yards per rush4.73.5
Red zone trips1-21-3
Penalties12-905-54
Turnovers04
Fumbles lost02
Defensive touchdowns10
Time of possession32:3127:29

Win probability

Above the line favours San Francisco 49ers, below favours Jacksonville Jaguars.

Venue

  • Levi's StadiumSanta Clara, CA
  • Attendance70495
  • OfficialsClete Blakeman, James Coleman, Kent Payne, Jonah Monroe, Scott Campbell, Karina Tovar, Andy Warner

Elsewhere

Picks for NFL

NFL rules and settlement

Most days: one sealed pick, free, before kick-off. Your first day of the main pick is free any day: code FIRSTDAY, no card.

A short email on days we have a pick. One click to stop, any time. 21+.

Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.