Bills Secure Victory Over Chargers at Home
Sunday, September 27, 2026, 1:00 PM ET · Highmark Stadium
Quick answers
Who won Los Angeles Chargers vs Buffalo Bills?
Buffalo Bills beat Los Angeles Chargers 24-16 at Highmark Stadium on September 27, 2026.
Who was favored in Los Angeles Chargers vs Buffalo Bills?
Buffalo Bills were the favorite at DraftKings, moneyline -345 (about 78% implied). The favorite won.
In a decisive matchup at Highmark Stadium, the Buffalo Bills triumphed over the Los Angeles Chargers with a final score of 24-16. This victory solidifies the Bills' impressive home record, bringing them to 4-1 at home this season. Meanwhile, the Chargers continue to struggle, remaining winless on the road with a record of 0-4.
The Bills entered this game on a three-game winning streak, having averaged 31.0 points scored and 23.0 points allowed over their last ten games. Their recent form has been strong, with a record of 8-2 in their last ten outings. In contrast, the Chargers have faced significant challenges, losing their last four games and averaging only 18.1 points scored while allowing 19.9 points in the same span.
In terms of home and away performance, the Bills have excelled at home, winning all three of their games this season. Their scoring average at home stands at 29.4 points over the last five games, showcasing their offensive capabilities. On the other hand, the Chargers have struggled away from home, with a record of 0-3 this season and an average of just 16.2 points scored in their last five games.
The matchup was notable not only for the teams' records but also for the injuries affecting both squads. The Bills had several players on the injury report, including Christian Benford, who was listed as questionable due to a toe injury. Other players like Ar'maj Reed-Adams, Skyler Bell, T.J. Sanders, and Jalon Kilgore were all out for the game, affecting the depth of the team. The Chargers also faced challenges with Donte Jackson being questionable due to a concussion, while DJ Uiagalelei, Brenen Thompson, Dalvin Tomlinson, and Charlie Kolar were all ruled out.
The betting market reflected the expectations for this game, with DraftKings setting the odds at BUF -7, indicating a strong belief in the Bills' ability to secure a comfortable win. The total for the game was set at 50.5, suggesting an expectation for a moderately high-scoring affair. The moneyline odds were -345 for the Bills and +275 for the Chargers, further emphasizing the disparity in confidence between the two teams.
Conditions at Highmark Stadium were conducive to a solid performance, and the Bills capitalized on their home-field advantage. Fans witnessed a game that highlighted the Bills' offensive strength against a Chargers defense that has struggled in recent weeks.
As the game unfolded, viewers were treated to a display of the Bills' offensive prowess, which has been a hallmark of their play this season. The final score of 24-16 not only reflects the outcome but also encapsulates the current trajectories of both teams as they navigate through the season.
What we said beforehand
The Buffalo Bills enter their upcoming game against the Los Angeles Chargers with a perfect home record of 2-0 this season, while the Chargers are struggling with an away record of 0-2. This matchup at Highmark Stadium on September 27, 2026, promises to be an intriguing clash given the contrasting fortunes of both teams.
The Bills have been in excellent form, winning their last five games, including victories over the Carolina Panthers (29-14), Cleveland Browns (31-7), Pittsburgh Steelers (28-27), Houston Texans (36-31), and Detroit Lions (41-31). They have averaged 31.0 points scored at home and have a current winning streak of three games. In their last ten home games, they hold an impressive record of 8-2, with an average of 29.4 points scored and 20.6 points allowed in their last five.
Conversely, the Chargers have faced significant challenges, losing their last four games. Their recent results include a win against the Houston Texans (27-7) followed by losses to the San Francisco 49ers (41-17), Los Angeles Rams (20-18), Arizona Cardinals (26-14), and Las Vegas Raiders (26-14). They have averaged only 16.2 points scored in their last five games, indicating a struggle to find offensive rhythm. Their overall record in the last ten games stands at 5-5, with a concerning away record of 0-2 this season.
In terms of previous meetings, there is no specific data provided in the block, but the current form of both teams suggests that the Bills will be favored in this matchup. The Bills have demonstrated a strong home advantage, while the Chargers have yet to secure a win on the road this season.
Injuries may also play a crucial role in the outcome of this game. The Bills will be without Skyler Bell, Ar'maj Reed-Adams, T.J. Sanders, Jalon Kilgore, and Jude Bowry, all of whom are listed as out. The Chargers will also be missing several key players, including Brenen Thompson, Dalvin Tomlinson, Charlie Kolar, Elijah Molden, and Alex Harkey, all of whom are out as well. The absence of these players could impact both teams' strategies and performance.
The betting market reflects the Bills' strong position, with DraftKings listing the Bills as 7-point favorites. The total points line is set at 50.5, with odds of -105 for the over and -115 for the under. The moneyline shows the Bills at -325 and the Chargers at +260, further emphasizing the Bills' status as the favored team.
Weather conditions for the game are expected to be sunny with a temperature of 66°F, a 55% chance of precipitation, and wind gusts of up to 15 mph. These conditions could influence gameplay, particularly in terms of passing and kicking.
Viewers should watch for Josh Allen's performance, as he leads the Bills with 582 passing yards and five touchdowns this season. James Cook III has also been a standout, leading the team in rushing with 192 yards and one touchdown. For the Chargers, Justin Herbert has thrown for 401 yards, with two touchdowns and three interceptions, indicating a need for improvement in his decision-making. Omarion Hampton leads the Chargers in rushing with 137 yards and two touchdowns.
As the Bills look to maintain their perfect home record and the Chargers aim to turn their season around, this matchup is set to be a compelling contest in the NFL.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | BUF -7 | 50.5 o -110 / u -110 | Los Angeles Chargers +275 · Buffalo Bills -345 |
Injury report
- Christian BenfordQuestionableToeBuffalo Bills
- Ar'maj Reed-AdamsOutElbowBuffalo Bills
- Skyler BellOutCoach's DecisionBuffalo Bills
- T.J. SandersOutBuffalo Bills
- Jalon KilgoreOutCoach's DecisionBuffalo Bills
- Donte JacksonQuestionableConcussionLos Angeles Chargers
- DJ UiagaleleiOutCoach's DecisionLos Angeles Chargers
- Brenen ThompsonOutQuadricepsLos Angeles Chargers
- Dalvin TomlinsonOutHamstringLos Angeles Chargers
- Charlie KolarOutForearmLos Angeles Chargers
Leaders
- Passing yardsJosh Allen16/26, 204 YDS, 2 INTBuffalo Bills
- Rushing yardsJames Cook III24 CAR, 154 YDS, 1 TDBuffalo Bills
- Receiving yardsDJ Moore6 REC, 67 YDSBuffalo Bills
- Passing yardsJustin Herbert20/34, 226 YDS, 1 TD, 1 INTLos Angeles Chargers
- Rushing yardsOmarion Hampton15 CAR, 56 YDSLos Angeles Chargers
- Receiving yardsTre' Harris6 REC, 76 YDSLos Angeles Chargers
Recent form
Buffalo Bills
Last 10: 8-2Streak W331 scored · 23 allowed per game4-1 at home
- W41-31vs Detroit LionsSep 18
- W36-31at Houston TexansSep 13
- W35-8vs New York JetsJan 4
- L12-13vs Philadelphia EaglesDec 28
- W23-20at Cleveland BrownsDec 21
- W35-31at New England PatriotsDec 14
- W39-34vs Cincinnati BengalsDec 7
- W26-7at Pittsburgh SteelersNov 30
- L19-23at Houston TexansNov 21
- W44-32vs Tampa Bay BuccaneersNov 16
Los Angeles Chargers
Last 10: 5-5Streak L418.1 scored · 19.9 allowed per game2-2 away
- L14-26vs Las Vegas RaidersSep 20
- L14-26vs Arizona CardinalsSep 13
- L3-19at Denver BroncosJan 4
- L16-20vs Houston TexansDec 27
- W34-17at Dallas CowboysDec 21
- W16-13at Kansas City ChiefsDec 14
- W22-19vs Philadelphia EaglesDec 9
- W31-14vs Las Vegas RaidersNov 30
- L6-35at Jacksonville JaguarsNov 16
- W25-10vs Pittsburgh SteelersNov 10
Standings
| Team | Lost | Points against | Points for | Tied | Win % | Won | Overall |
|---|---|---|---|---|---|---|---|
| Kansas City | 0 | 50 | 88 | 0 | 1.000 | 3 | 3-0 |
| Las Vegas | 0 | 27 | 53 | 0 | 1.000 | 2 | 2-0 |
| Denver | 1 | 44 | 30 | 0 | .500 | 1 | 1-1 |
| Los Angeles | 3 | 76 | 44 | 0 | .000 | 0 | 0-3 |
| Buffalo | 0 | 78 | 101 | 0 | 1.000 | 3 | 3-0 |
| New York | 2 | 61 | 64 | 0 | .333 | 1 | 1-2 |
| New England | 2 | 51 | 36 | 0 | .333 | 1 | 1-2 |
| Miami | 3 | 86 | 36 | 0 | .000 | 0 | 0-3 |
Box score
| Stat | Los Angeles Chargers | Buffalo Bills |
|---|---|---|
| First downs | 20 | 22 |
| First downs passing | 11 | 10 |
| First downs rushing | 6 | 11 |
| First downs by penalty | 3 | 1 |
| Third downs | 6-15 | 6-12 |
| Fourth downs | 0-1 | 2-2 |
| Offensive plays | 64 | 63 |
| Total yards | 348 | 350 |
| Yards per play | 5.4 | 5.6 |
| Drives | 11 | 11 |
| Net passing yards | 217 | 174 |
| Completions | 20/34 | 16/26 |
| Yards per pass | 6.0 | 5.8 |
| Interceptions thrown | 1 | 2 |
| Sacks allowed | 2-9 | 4-30 |
| Rushing yards | 131 | 176 |
| Rushing attempts | 28 | 33 |
| Yards per rush | 4.7 | 5.3 |
| Red zone trips | 1-4 | 3-4 |
| Penalties | 7-50 | 10-88 |
| Turnovers | 1 | 5 |
| Fumbles lost | 0 | 3 |
| Defensive touchdowns | 0 | 0 |
| Time of possession | 31:22 | 28:38 |
Win probability
Above the line favours Buffalo Bills, below favours Los Angeles Chargers.
Venue
- Highmark StadiumOrchard Park, NY
- Attendance60361
- OfficialsClete Blakeman, James Coleman, Greg Meyer, Kent Payne, Tab Slaughter, Karina Tovar, Andy Warner
Elsewhere
- Allen, Bills outlast Chargers 24-16 despite committing 5 turnovers
- Los Angeles Chargers vs. Buffalo Bills: Game Highlights
- Tennessee Titans vs. New York Giants: Game Highlights
- Kenneth Walker III has 2 TDs as Chiefs beat Dolphins 24-10 after De'Von Achane exits with injury
- Lawrence throws 3 TD passes as Jaguars rout Patriots and raise more questions about Maye
- Week 3 NFL highlights: Best plays, moments, touchdowns, more