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NFL · Final

Rams Dominate Cardinals in Convincing Victory

Sunday, December 7, 2025, 4:25 PM ET · State Farm Stadium

Los Angeles Rams 45, Arizona Cardinals 17, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Los Angeles Rams vs Arizona Cardinals?

Los Angeles Rams beat Arizona Cardinals 45-17 at State Farm Stadium on December 7, 2025.

Who was favored in Los Angeles Rams vs Arizona Cardinals?

Los Angeles Rams were the favorite at DraftKings, moneyline -485 (about 83% implied). The favorite won.

The Los Angeles Rams delivered a commanding performance against the Arizona Cardinals, winning decisively with a final score of 45-17. This matchup highlighted the stark contrast in the teams' recent forms, with the Rams entering the game with a record of 10-3, while the Cardinals struggled at 3-10.

The Rams had been performing well, boasting a record of 7-3 over their last ten games, although they faced a setback in their most recent outing, losing 31-28 to the Carolina Panthers. Despite this loss, they averaged 28.7 points scored per game while allowing only 18.2 points, showcasing their offensive strength and defensive resilience. In contrast, the Cardinals had a dismal stretch, going 1-9 in their last ten games, including a four-game losing streak. They averaged 21.8 points scored but allowed 26.8 points, indicating significant defensive vulnerabilities.

Playing at home, the Cardinals had a record of 0-5, while their away record stood at 1-4. This home disadvantage was evident as they struggled to find form at State Farm Stadium. The Rams, on the other hand, had a solid away record of 3-2, further emphasizing their capability to perform outside of their home venue.

In their previous encounters, the teams were evenly matched with a record of 1-1 in their last two meetings. The Cardinals won the first game of the 2024 season 41-10 at home, while the Rams took the second match later that season with a narrow 13-9 victory on the road.

Injuries played a significant role in the game, particularly for the Cardinals. Key players such as James Conner and Zachary Carter were on Injured Reserve, while Jeremiyah Love and Will Johnson were listed as questionable. The Rams also dealt with injuries, including Alex Johnson on Injured Reserve and Myles Garrett and Puka Nacua both listed as questionable.

The betting market reflected the Rams' dominance, with DraftKings setting the spread at 9.5 points in favor of Los Angeles. The total points line was set at 49.5, with both the over and under priced at -110. The moneyline indicated significant confidence in the Rams, with odds of -485, while the Cardinals were at +370.

The game conditions were typical for December, with players needing to adapt to cooler temperatures. Fans were treated to a matchup that showcased the Rams' offensive prowess and the Cardinals' ongoing struggles. Viewers were encouraged to watch for the Rams' ability to exploit the Cardinals' defensive weaknesses, as well as the performance of the Cardinals' offense in trying to overcome their recent challenges.

Odds

BookSpreadTotalMoneyline
DraftKingsLAR -9.5 49.5 o -110 / u -110 Los Angeles Rams -485 · Arizona Cardinals +370

What these prices pay on $100 · What these numbers mean

Injury report

  • Jeremiyah LoveQuestionableAnkleArizona Cardinals
  • Zachary CarterInjured ReserveKneeArizona Cardinals
  • Will JohnsonQuestionableLower BodyArizona Cardinals
  • Tip ReimanOutAnkleArizona Cardinals
  • James ConnerInjured ReserveFootArizona Cardinals
  • Alex JohnsonInjured ReserveUndisclosedLos Angeles Rams
  • Myles GarrettQuestionableKneeLos Angeles Rams
  • Puka NacuaQuestionableGroinLos Angeles Rams
  • Justin DedichInjured ReserveUndisclosedLos Angeles Rams
  • Keagen TrostInjured ReserveHamstringLos Angeles Rams

Leaders

  • Passing yardsJacoby Brissett25/44, 271 YDS, 2 TD, 1 INTArizona Cardinals
  • Rushing yardsJacoby Brissett4 CAR, 22 YDSArizona Cardinals
  • Receiving yardsMichael Wilson11 REC, 142 YDS, 2 TDArizona Cardinals
  • Passing yardsMatthew Stafford22/31, 281 YDS, 3 TDLos Angeles Rams
  • Rushing yardsBlake Corum12 CAR, 128 YDS, 2 TDLos Angeles Rams
  • Receiving yardsPuka Nacua7 REC, 167 YDS, 2 TDLos Angeles Rams

Recent form

Arizona Cardinals

Last 10: 1-9Streak L421.8 scored · 26.8 allowed per game0-5 at home

  • L17-20at Tampa Bay BuccaneersNov 30
  • L24-27vs Jacksonville JaguarsNov 23
  • L22-41vs San Francisco 49ersNov 16
  • L22-44at Seattle SeahawksNov 9
  • W27-17at Dallas CowboysNov 4
  • L23-27vs Green Bay PackersOct 19
  • L27-31at Indianapolis ColtsOct 12
  • L21-22vs Tennessee TitansOct 5
  • L20-23vs Seattle SeahawksSep 26
  • L15-16at San Francisco 49ersSep 21

Los Angeles Rams

Last 10: 7-3Streak L128.7 scored · 18.2 allowed per game3-2 away

  • L28-31at Carolina PanthersNov 30
  • W34-7vs Tampa Bay BuccaneersNov 24
  • W21-19vs Seattle SeahawksNov 16
  • W42-26at San Francisco 49ersNov 9
  • W34-10vs New Orleans SaintsNov 2
  • W35-7at Jacksonville JaguarsOct 19
  • W17-3at Baltimore RavensOct 12
  • L23-26vs San Francisco 49ersOct 3
  • W27-20vs Indianapolis ColtsSep 28
  • L26-33at Philadelphia EaglesSep 21

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1

Box score

StatLos Angeles RamsArizona Cardinals
First downs3017
First downs passing1315
First downs rushing152
First downs by penalty20
Third downs3-84-12
Fourth downs0-00-1
Offensive plays6761
Total yards530314
Yards per play7.95.1
Drives1111
Net passing yards281263
Completions22/3125/44
Yards per pass9.15.6
Interceptions thrown01
Sacks allowed0-03-8
Rushing yards24951
Rushing attempts3614
Yards per rush6.93.6
Red zone trips3-42-4
Penalties5-307-42
Turnovers01
Fumbles lost00
Defensive touchdowns00
Time of possession35:0424:56

Win probability

Above the line favours Arizona Cardinals, below favours Los Angeles Rams.

Venue

  • State Farm StadiumGlendale, AZ
  • Attendance61970
  • OfficialsBarry Anderson, Ronald Torbert, Keith Washington, Ryan Dickson, Brian Bolinger, Frank LeBlanc, Courtney Brown

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.