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NFL · Final

49ers Dominate Dolphins in Convincing Win

Sunday, September 20, 2026, 4:25 PM ET · Levi's Stadium

San Francisco 49ers 35, Miami Dolphins 13, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Miami Dolphins vs San Francisco 49ers?

San Francisco 49ers beat Miami Dolphins 35-13 at Levi's Stadium on September 20, 2026.

Who was favored in Miami Dolphins vs San Francisco 49ers?

San Francisco 49ers were the favorite at DraftKings, moneyline -900 (about 90% implied). The favorite won.

The San Francisco 49ers showcased their dominance with a decisive 35-13 victory over the Miami Dolphins at Levi's Stadium. This matchup highlighted the stark contrast in the teams' recent performances, as the 49ers improved their season record to 3-0, while the Dolphins fell to 0-3. The 49ers entered the game with a strong home record of 2-0 and had been averaging 30.4 points per game over their last ten outings, while allowing just 21.4 points. In contrast, the Dolphins struggled on the road, with a record of 0-2 and an average of only 18.6 points scored per game in their last ten, while conceding an average of 23.6 points.

The 49ers had been on a one-game winning streak, having won their previous game against the Los Angeles Rams 27-7. Their strong offensive performance continued against the Dolphins, as they scored five touchdowns, demonstrating their ability to put points on the board consistently. Miami, on the other hand, faced their second consecutive loss, having lost their last game to the Las Vegas Raiders 13-27. The Dolphins' scoring woes were evident, as they managed only 13 points against a formidable 49ers defense.

At home, the 49ers maintained a solid record of 3-2, while the Dolphins struggled with a 1-3 record on the road. This game further emphasized the 49ers' strength at Levi's Stadium, where they have been difficult to beat. The matchup also marked a significant moment for both teams, as the 49ers looked to solidify their position in the league, while the Dolphins sought to turn their season around.

In terms of injuries, the 49ers had several players listed as questionable, including Demarcus Robinson (ankle), Mike Evans (hip), James Thompson Jr. (ankle), and Jack Jones (foot). Jordan Watkins was ruled out due to a coach's decision. The Dolphins also faced injury concerns, with Caleb Douglas (ankle), Robert Beal Jr. (hamstring), and Jaylen Wright (neck) all listed as questionable. Brady Cook and Jalen Tolbert were out due to coach's decisions, further complicating the Dolphins' roster.

The betting market reflected the 49ers' strong position, with DraftKings setting the spread at -12.5 in favor of San Francisco and a total of 44.5 points for the game. The odds indicated a clear expectation of a 49ers victory, with their moneyline set at -900. In contrast, the Dolphins' moneyline was listed at +600, highlighting the perceived disparity between the two teams.

Conditions at Levi's Stadium were favorable for football, contributing to a competitive atmosphere. Fans witnessed a well-rounded performance from the 49ers, who not only excelled offensively but also displayed a robust defense that limited the Dolphins' scoring opportunities.

Viewers were treated to a display of the 49ers' offensive prowess, characterized by efficient passing and a strong running game. The team's ability to capitalize on scoring chances was evident, as they converted several drives into touchdowns. The Dolphins, however, struggled to find their rhythm, unable to match the intensity and execution of the 49ers.

Overall, the game served as a reminder of the 49ers' potential as a playoff contender, while the Dolphins face significant challenges as they look to regroup and find their footing in the coming weeks.

What we said beforehand

The San Francisco 49ers will face off against the Miami Dolphins at Levi's Stadium on September 20, 2026, in a matchup that promises to be intriguing given the contrasting fortunes of both teams. The 49ers enter this game with a home record of 1-0, while the Dolphins are looking to bounce back from an away record of 0-1.

The 49ers have shown strong form recently, winning four of their last five games. Their most recent outing was a convincing victory against the Los Angeles Rams, where they won 27-7 on September 11, 2026. In their last five games, they have averaged 31.4 points scored while allowing 21.8 points. Notably, quarterback Brock Purdy has been a standout performer, throwing for 205 yards, three touchdowns, and one interception in their last game.

In contrast, the Dolphins have struggled, losing their last two games and holding a record of 1-4 in their last five outings. Their latest defeat came against the Las Vegas Raiders, where they lost 27-13 on September 13, 2026. Miami's offense has averaged just 15.8 points in their last five games, while their defense has allowed an average of 31.0 points.

Historically, the 49ers have been formidable at home, with a record of 8-2 in their last ten home games. They have averaged 30.4 points scored and allowed 21.4 points during this stretch. Meanwhile, the Dolphins have struggled on the road, with a 1-3 record in their last four away games. Their offensive struggles have been evident, as they have averaged just 18.6 points scored in their last ten games overall.

In terms of injuries, the 49ers will be without Jordan Watkins, Kurtis Rourke, Ephesians Prysock, Enrique Cruz Jr., and Tatum Bethune, all of whom are out due to coach's decisions. The Dolphins will also be missing key players, including Brady Cook, Jalen Tolbert, and Chop Robinson, who is out due to a concussion, along with Justin Joly and Marcellas Dial Jr., all due to coach's decisions.

The betting market reflects the 49ers' strong position, with DraftKings listing them as 12.5-point favorites. The total for the game is set at 44.5 points, with the over at -115 and the under at -105. The 49ers are priced at -900 on the moneyline, while the Dolphins sit at +600.

Weather conditions for the game are expected to be mild, with a temperature of 67°F and no precipitation forecasted. Wind gusts may reach up to 14 mph, which could play a role in the passing game.

As the game approaches, viewers should watch for how the 49ers' offense, led by Purdy and running back Christian McCaffrey, performs against a struggling Dolphins defense. Conversely, the Dolphins will need to find a way to generate offense, especially with Malik Willis at the helm, who has shown flashes of potential but has struggled to lead his team to victory in recent weeks.

Odds

BookSpreadTotalMoneyline
DraftKingsSF -12.5 44.5 o -115 / u -105 Miami Dolphins +600 · San Francisco 49ers -900

What these prices pay on $100 · What these numbers mean

Injury report

  • Demarcus RobinsonQuestionableAnkleSan Francisco 49ers
  • Mike EvansQuestionableHipSan Francisco 49ers
  • James Thompson Jr.QuestionableAnkleSan Francisco 49ers
  • Jack JonesQuestionableFootSan Francisco 49ers
  • Jordan WatkinsOutCoach's DecisionSan Francisco 49ers
  • Caleb DouglasQuestionableAnkleMiami Dolphins
  • Robert Beal Jr.QuestionableHamstringMiami Dolphins
  • Jaylen WrightQuestionableNeckMiami Dolphins
  • Brady CookOutCoach's DecisionMiami Dolphins
  • Jalen TolbertOutCoach's DecisionMiami Dolphins

Leaders

  • Passing yardsBrock Purdy20/22, 287 YDS, 2 TDSan Francisco 49ers
  • Rushing yardsBrock Purdy3 CAR, 30 YDS, 1 TDSan Francisco 49ers
  • Receiving yardsGeorge Kittle4 REC, 80 YDS, 1 TDSan Francisco 49ers
  • Passing yardsMalik Willis14/23, 197 YDS, 1 TDMiami Dolphins
  • Rushing yardsDe'Von Achane20 CAR, 74 YDSMiami Dolphins
  • Receiving yardsRyan Miller1 REC, 77 YDS, 1 TDMiami Dolphins

Recent form

San Francisco 49ers

Last 10: 8-2Streak W130.4 scored · 21.4 allowed per game3-2 at home

  • W27-7at Los Angeles RamsSep 11
  • L3-13vs Seattle SeahawksJan 4
  • W42-38vs Chicago BearsDec 29
  • W48-27at Indianapolis ColtsDec 23
  • W37-24vs Tennessee TitansDec 14
  • W26-8at Cleveland BrownsNov 30
  • W20-9vs Carolina PanthersNov 25
  • W41-22at Arizona CardinalsNov 16
  • L26-42vs Los Angeles RamsNov 9
  • W34-24at New York GiantsNov 2

Miami Dolphins

Last 10: 5-5Streak L218.6 scored · 23.6 allowed per game1-3 away

  • L13-27at Las Vegas RaidersSep 13
  • L10-38at New England PatriotsJan 4
  • W20-17vs Tampa Bay BuccaneersDec 28
  • L21-45vs Cincinnati BengalsDec 21
  • L15-28at Pittsburgh SteelersDec 16
  • W34-10at New York JetsDec 7
  • W21-17vs New Orleans SaintsNov 30
  • W16-13vs Washington CommandersNov 16
  • W30-13vs Buffalo BillsNov 9
  • L6-28vs Baltimore RavensOct 31

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Buffalo0627701.00022-0
New England116300.50011-1
New York130400.50011-1
Miami262260.00000-2
Seattle0174401.00022-0
San Francisco0206201.00022-0
Arizona145330.50011-1
Los Angeles12770.00000-1

Box score

StatMiami DolphinsSan Francisco 49ers
First downs1323
First downs passing816
First downs rushing46
First downs by penalty11
Third downs7-155-7
Fourth downs1-20-0
Offensive plays5649
Total yards284382
Yards per play5.17.8
Drives88
Net passing yards182287
Completions14/2320/22
Yards per pass6.713.0
Interceptions thrown00
Sacks allowed4-150-0
Rushing yards10295
Rushing attempts2927
Yards per rush3.53.5
Red zone trips0-25-5
Penalties7-507-78
Turnovers00
Fumbles lost00
Defensive touchdowns00
Time of possession30:1329:47

Win probability

Above the line favours San Francisco 49ers, below favours Miami Dolphins.

Venue

  • Levi's StadiumSanta Clara, CA
  • Attendance70878
  • OfficialsDino Paganelli, Dyrol Prioleau, Jeff Seeman, Keith Parham, Shawn Smith, Tra Blake, Jay Bilbo

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.