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MLB · Final

Guardians Defeat Twins 5-2 in Key Matchup

Tuesday, July 21, 2026, 6:40 PM ET · Progressive Field

Cleveland Guardians 5, Minnesota Twins 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Minnesota Twins vs Cleveland Guardians?

Cleveland Guardians beat Minnesota Twins 5-2 at Progressive Field on July 21, 2026.

Who was favored in Minnesota Twins vs Cleveland Guardians?

Cleveland Guardians were the favorite at DraftKings, moneyline -162 (about 62% implied). The favorite won.

The Cleveland Guardians secured a 5-2 victory over the Minnesota Twins at Progressive Field, marking a crucial win in this tightly contested series, which is now tied 2-2. This game was notable not only for its implications in the standings but also for the performance of both teams, who have been battling it out throughout the season.

Cleveland entered the game with a home record of 54-48, while Minnesota held a record of 49-53 on the road. The Guardians have shown a solid home performance recently, going 5-4-1 in their last ten games, with an average of 3.8 runs scored and 3.4 runs allowed per game. They are currently on a one-game winning streak, having won their previous matchup against the Twins 13-4 just a day prior. In contrast, the Twins have struggled away from home, going 6-4 in their last ten games but recently lost their last two games, averaging 4.5 runs scored and 4.7 runs allowed.

In terms of their recent head-to-head matchups, Cleveland has edged Minnesota, winning 9 of the last 18 meetings, including two victories earlier in July. The Guardians prevailed 5-2 in their previous encounter on July 9 and also faced the Twins on July 8, where they lost a close game 5-6. This series has highlighted the competitive nature of both teams, with each game closely contested.

Injury concerns have also shaped the teams' performances. The Guardians are missing key players such as Slade Cecconi, Rhys Hoskins, and Shawn Armstrong due to various injuries, which could impact their depth. The Twins are also dealing with injuries to significant players, including Byron Buxton, Joe Ryan, and Austin Martin, all of whom are on the injured list. These absences have forced both teams to adjust their lineups and strategies.

The betting market, as provided by DraftKings, had the Guardians favored at -162 on the money line, with a spread of -1.5 and a total set at 8.0 runs. The odds indicate a clear expectation for the Guardians to perform well at home, which they did in this matchup.

The game conditions were favorable for baseball, with no significant weather issues reported. Fans watching the game were treated to a series of scoring plays that highlighted the Guardians' offensive capabilities. The Twins struck first in the first inning with a home run from Jeffers, but the Guardians quickly responded in the third inning with a double from Kwan, allowing Hedges to score. Rocchio then put Cleveland ahead with a single that brought Kwan home.

The fourth inning saw some defensive mishaps from the Guardians, allowing the Twins to tie the game 2-2 after Bell scored on an error. However, Cleveland regained the lead in the sixth inning with a sacrifice fly from Hedges, followed by another sacrifice fly from Halpin that extended their lead to 4-2. Bazzana capped off the scoring for the Guardians in the seventh inning with a single that brought Manzardo home, solidifying the 5-2 victory.

Overall, this game showcased the Guardians' resilience and ability to capitalize on their home field advantage, while the Twins will need to regroup and address their recent struggles as they continue their season.

Odds

BookSpreadTotalMoneyline
DraftKingsCLE -162 8 o -102 / u -118 Minnesota Twins +134 · Cleveland Guardians -162

What these prices pay on $100 · What these numbers mean

Injury report

  • Slade Cecconi15-Day-ILArmCleveland Guardians
  • Rhys Hoskins10-Day-ILBackCleveland Guardians
  • Shawn Armstrong60-Day-ILCalfCleveland Guardians
  • Byron Buxton10-Day-ILHipMinnesota Twins
  • Joe Ryan15-Day-ILLower BodyMinnesota Twins
  • Austin Martin10-Day-ILHamstringMinnesota Twins
  • Mike Paredes60-Day-ILObliqueMinnesota Twins
  • Mick Abel60-Day-ILElbowMinnesota Twins

Recent form

Cleveland Guardians

Last 10: 5-4-1Streak W13.8 scored · 3.4 allowed per game1-2 at home

  • W13-4vs Minnesota TwinsJul 20
  • L1-7vs Pittsburgh PiratesJul 19
  • L1-7vs Pittsburgh PiratesJul 18
  • D0-0vs Pittsburgh PiratesJul 17
  • W5-2at Miami MarlinsJul 12
  • W4-1at Miami MarlinsJul 11
  • W3-2at Miami MarlinsJul 10
  • W5-2at Minnesota TwinsJul 9
  • L5-6at Minnesota TwinsJul 8
  • L1-3at Minnesota TwinsJul 7

Minnesota Twins

Last 10: 6-4Streak L24.5 scored · 4.7 allowed per game3-2 away

  • L4-13at Cleveland GuardiansJul 20
  • L1-10at Chicago CubsJul 19
  • W5-2at Chicago CubsJul 18
  • W4-2vs Los Angeles AngelsJul 12
  • L3-4vs Los Angeles AngelsJul 11
  • L2-5vs Cleveland GuardiansJul 9
  • W6-5vs Cleveland GuardiansJul 8
  • W3-1vs Cleveland GuardiansJul 7
  • W6-1at New York YankeesJul 5
  • W11-4at New York YankeesJul 4

Standings

TeamGames behindLostStreakWin %Won
Chicago-66L1.52573
Cleveland369L1.50470
Minnesota6.573L1.47967
Detroit975W1.46064
Kansas City11.578L3.44362

How the scoring went

  1. 1st Inning1-0Jeffers homered to left (402 feet).
  2. 3rd Inning1-1Kwan doubled to center, Hedges scored.
  3. 3rd Inning1-2Rocchio singled to right, Kwan scored.
  4. 4th Inning2-2Bell scored on error, Lewis safe at first on fielding error by pitcher Messick, Lewis safe at second on throwing error by second baseman Bazzana.
  5. 6th Inning2-3Hedges hit sacrifice fly to left, Watson scored.
  6. 6th Inning2-4Halpin hit sacrifice fly to center, Bazzana scored, Arias to third. Cleveland Guardians challenged: call on the field was overturned.
  7. 7th Inning2-5Bazzana singled to left, Manzardo scored.

Win probability

Above the line favours Cleveland Guardians, below favours Minnesota Twins.

Venue

  • Progressive FieldCleveland, Ohio
  • Attendance19714
  • OfficialsNestor Ceja, Willie Traynor, Charlie Ramos, David Rackley

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.