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MLB · Final

Pirates Claim Series Victory Over Cardinals

Thursday, May 21, 2026, 1:15 PM ET · Busch Stadium

Pittsburgh Pirates 6, St. Louis Cardinals 2, final. Our MLB picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Pittsburgh Pirates vs St. Louis Cardinals?

Pittsburgh Pirates beat St. Louis Cardinals 6-2 at Busch Stadium on May 21, 2026.

Who was favored in Pittsburgh Pirates vs St. Louis Cardinals?

Pittsburgh Pirates were the favorite at DraftKings, moneyline -120 (about 55% implied). The favorite won.

In a decisive matchup at Busch Stadium, the Pittsburgh Pirates defeated the St. Louis Cardinals 6-2, clinching the series 2-1. This victory was significant for the Pirates, who improved their away record to 27-24, while the Cardinals fell to 28-22 at home. The game showcased a strong performance from the Pirates, who capitalized on their recent momentum, having won their last game against the Cardinals just the previous day.

The Pirates entered this game with a record of 4-6 over their last ten games, but they managed to secure a win in their most recent outing, demonstrating a slight resurgence in form. Their scoring average during this stretch was 5.1 runs per game, while they allowed an average of 5.3 runs. In contrast, the Cardinals have struggled recently, posting a 5-5 record in their last ten games and suffering a loss in their last match against the Pirates, where they were shut out 0-7. The Cardinals averaged 3.4 runs scored and 3.9 runs allowed during this period, indicating their offensive struggles.

At home, the Cardinals held a record of 2-3 in their last five games, averaging 3.2 runs scored and allowing 5.0 runs. The Pirates, on the other hand, had a more balanced away record of 2-2 in their last five games, with an average of 4.4 runs scored and 6.4 runs allowed. These statistics reflect the challenges both teams faced heading into this contest.

In terms of head-to-head matchups, the Pirates have had the upper hand recently, winning 11 of the last 19 meetings against the Cardinals. This included victories earlier in the season, with the Pirates winning 10-5 and 5-4 in their previous encounters, showcasing their offensive capabilities against the Cardinals' pitching staff.

Injuries played a role in the game, particularly for the Cardinals, who were missing several key players. Everson Pereira and Masyn Winn were on the 10-day injured list, while Ramon Urias was day-to-day with an arm issue. Andre Pallante was also on the 15-day injured list due to an elbow injury, and JJ Wetherholt was on the 10-day injured list with a wrist issue. The Pirates were not without their own injury concerns, with Konnor Griffin and Mitch Keller on the 60-day injured list, and Ryan O'Hearn on the 10-day injured list with a quadriceps injury.

The betting market reflected the Pirates' recent form, with DraftKings pricing the Pirates at -120 and the Cardinals at -101 on the money line. The spread was set at 1.5 runs, with a total of 7.0 runs for the game. The odds for the over were -112.0, while the under was priced at -107.0, indicating a competitive expectation for the game.

Conditions at Busch Stadium were conducive to baseball, and fans were treated to an exciting game. The scoring began in the first inning when Lowe homered to left field, giving the Pirates an early lead. The Cardinals responded in the third inning with a homer from Herrera, but the Pirates quickly regained control in the fourth inning with a fielder's choice that allowed Griffin to score.

The Pirates continued to build their lead with a two-run single from Ozuna in the sixth inning, followed by a homer from Davis in the seventh. The Cardinals managed to score again in the eighth inning, but it was too little too late as the Pirates secured the victory.

Overall, this game highlighted the Pirates' ability to capitalize on their recent form and the Cardinals' ongoing struggles, particularly in the face of injuries. The series win for the Pirates not only boosts their confidence but also places them in a stronger position within the league.

Odds

BookSpreadTotalMoneyline
DraftKingsPIT -120 7 o -112 / u -107 Pittsburgh Pirates -120 · St. Louis Cardinals -101

What these prices pay on $100 · What these numbers mean

Injury report

  • Everson Pereira10-Day-ILHandSt. Louis Cardinals
  • Ramon UriasDay-To-DayArmSt. Louis Cardinals
  • Masyn Winn10-Day-ILThumbSt. Louis Cardinals
  • Andre Pallante15-Day-ILElbowSt. Louis Cardinals
  • JJ Wetherholt10-Day-ILWristSt. Louis Cardinals
  • Konnor Griffin60-Day-ILFingerPittsburgh Pirates
  • Ryan O'Hearn10-Day-ILQuadricepsPittsburgh Pirates
  • Mitch Keller60-Day-ILArmPittsburgh Pirates
  • Endy Rodriguez60-Day-ILHipPittsburgh Pirates

Recent form

St. Louis Cardinals

Last 10: 5-5Streak L13.4 scored · 3.9 allowed per game2-3 at home

  • L0-7vs Pittsburgh PiratesMay 20
  • W9-6vs Pittsburgh PiratesMay 19
  • L0-2vs Kansas City RoyalsMay 17
  • W5-4vs Kansas City RoyalsMay 16
  • L2-6at AthleticsMay 14
  • W6-4at AthleticsMay 13
  • L2-3at San Diego PadresMay 10
  • W6-0at San Diego PadresMay 9
  • W2-1at San Diego PadresMay 8
  • L2-6vs Milwaukee BrewersMay 6

Pittsburgh Pirates

Last 10: 4-6Streak W15.1 scored · 5.3 allowed per game2-2 away

  • W7-0at St. Louis CardinalsMay 20
  • L6-9at St. Louis CardinalsMay 19
  • L0-6vs Philadelphia PhilliesMay 17
  • L0-6vs Philadelphia PhilliesMay 16
  • L9-11vs Philadelphia PhilliesMay 15
  • W7-2vs Colorado RockiesMay 14
  • L4-10vs Colorado RockiesMay 13
  • W3-1vs Colorado RockiesMay 12
  • W13-3at San Francisco GiantsMay 10
  • L2-5at San Francisco GiantsMay 9

Standings

TeamGames behindLostStreakWin %Won
Milwaukee-53W2.62187
Chicago962L2.55778
St. Louis1770W2.50070
Pittsburgh1972L1.48668
Cincinnati2073W2.47967

How the scoring went

  1. 1st Inning1-0Lowe homered to left (342 feet).
  2. 3rd Inning1-1Herrera homered to left center (408 feet).
  3. 4th Inning2-1Mangum grounded into fielder's choice to second, Griffin scored, Ozuna out at second.
  4. 6th Inning4-1Ozuna singled to left, Horwitz scored and Griffin scored.
  5. 7th Inning5-1Davis homered to left (375 feet).
  6. 7th Inning6-1Reynolds grounded out to shortstop, Cruz scored, Lowe to second.
  7. 8th Inning6-2Walker singled to left, Herrera scored, Burleson to second.

Win probability

Above the line favours St. Louis Cardinals, below favours Pittsburgh Pirates.

Venue

  • Busch StadiumSt. Louis, Missouri
  • Attendance27705
  • OfficialsJames Hoye, Tyler Jones, D.J. Reyburn, John Libka

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.