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NFL · Final

Falcons Defeat 49ers in Thrilling Matchup

Sunday, October 25, 2026, 1:00 PM ET · Mercedes-Benz Stadium

Atlanta Falcons 29, San Francisco 49ers 20, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won San Francisco 49ers vs Atlanta Falcons?

Atlanta Falcons beat San Francisco 49ers 29-20 at Mercedes-Benz Stadium on October 25, 2026.

Who was favored in San Francisco 49ers vs Atlanta Falcons?

San Francisco 49ers were the favorite at DraftKings, moneyline -142 (about 59% implied). The underdog won.

In an exciting NFL clash at Mercedes-Benz Stadium, the Atlanta Falcons emerged victorious against the San Francisco 49ers with a final score of 29-20. This result marks a significant turnaround for the Falcons, who had been struggling in recent weeks, while the 49ers, despite their strong season, faced a setback in this matchup.

The Falcons entered this game with a home record of 3-4 and had been on a two-game losing streak, having lost to the Chicago Bears and the Baltimore Ravens in their previous outings. Their performance at home had been inconsistent, with an average of 24.3 points scored and 24.1 points allowed over their last ten games. In contrast, the 49ers boasted an impressive away record of 6-1 and were riding a six-game winning streak, averaging 30.7 points scored while allowing only 21.2 points during that stretch.

Historically, the Falcons had struggled against the 49ers, losing their previous meeting in the 2025 season by a score of 10-20. This backdrop added to the intrigue of the matchup, as the Falcons sought to change their fortunes against a formidable opponent. The game was also marked by notable injuries, with the Falcons missing key players such as Avieon Terrell (back), Olamide Zaccheaus (shoulder), and Brian Robinson Jr. (hamstring), among others. The 49ers also faced significant absences, including Deebo Samuel Sr. (hamstring) and Marques Sigle (ankle).

The betting market, as provided by DraftKings, had the 49ers favored by 2.5 points, with a total set at 49.5. The odds indicated a competitive matchup, reflecting the 49ers' strong season but also acknowledging the Falcons' potential to capitalize on home-field advantage.

As the game unfolded, the Falcons demonstrated resilience and adaptability, effectively leveraging their home environment to secure the win. The conditions at Mercedes-Benz Stadium were conducive to a high-scoring affair, and the Falcons capitalized on their opportunities, ultimately outpacing the 49ers in a closely contested battle.

Viewers were treated to a display of strategic football, with both teams showcasing their strengths and attempting to exploit weaknesses. The Falcons' ability to score in critical moments proved decisive, allowing them to overcome their recent struggles and deliver a statement victory against a top-tier opponent.

What we said beforehand

The San Francisco 49ers come into their matchup against the Atlanta Falcons with an impressive record of 6-0, making them one of the last undefeated teams in the NFL. The game is set to take place at Mercedes-Benz Stadium on October 25, 2026, at 17:00 UTC. In contrast, the Falcons are struggling with a record of 2-4, having lost their last two games. This stark difference in performance sets the stage for an intriguing contest as the Falcons look to turn their season around against a formidable opponent.

In their last five games, the Falcons have recorded two wins and three losses. They achieved victories against the Green Bay Packers (35-14) and the New Orleans Saints (45-24), but suffered defeats against the Carolina Panthers (34-3), the Baltimore Ravens (30-23 in overtime), and the Chicago Bears (31-23). Atlanta has averaged 25.8 points scored per game in their last five outings but has also allowed an average of 26.6 points, indicating defensive vulnerabilities. At home, their record is 2-3, with an average of 24.3 points scored and 24.1 points allowed per game.

On the other hand, the 49ers are riding a six-game winning streak, having won all their games this season. Their recent victories include a 23-17 win against the Washington Commanders and a nail-biting 32-29 win over the Seattle Seahawks. San Francisco has been prolific on offense, averaging 30.0 points scored and allowing 20.6 points in their last five games. Their away record stands at 3-0, showcasing their ability to perform outside of their home turf.

Historically, the Falcons and 49ers have met once in the previous season, where the 49ers emerged victorious with a score of 20-10. This previous meeting adds an additional layer of motivation for the Falcons as they seek to avenge that loss.

In terms of injuries, the Falcons will be without several key players, including Avieon Terrell (back), Olamide Zaccheaus (shoulder), Brian Robinson Jr. (hamstring), and quarterback Andy Dalton, who is out due to a coach's decision. The absence of these players could significantly impact Atlanta's performance as they face a strong 49ers team. Similarly, the 49ers will also miss key contributors, including Deebo Samuel Sr. (hamstring), Marques Sigle (ankle), and Garret Wallow (hamstring), which could affect their offensive strategy.

The betting market reflects the 49ers' dominance, with DraftKings listing them as 2.5-point favorites. The total points line is set at 49.5, indicating expectations for a moderately high-scoring game. The odds for the 49ers to win straight up are -155, while the Falcons are listed at +130.

Weather conditions for the game are expected to be favorable, with a temperature of 68°F, no precipitation, and wind gusts reaching 21 mph. These conditions should not significantly hinder gameplay, allowing both teams to execute their strategies effectively.

As the game approaches, viewers should watch for how the Falcons' offense, led by quarterback Michael Penix Jr. and running back Bijan Robinson, adapts to the absence of key players. The 49ers' defense will be tested against a Falcons offense that has shown flashes of brilliance despite its recent struggles. Similarly, the 49ers' high-powered offense, spearheaded by quarterback Brock Purdy and running back Christian McCaffrey, will aim to exploit any weaknesses in the Falcons' defense. This matchup promises to be a compelling clash of contrasting fortunes as the Falcons strive to upset the undefeated 49ers.

Odds

BookSpreadTotalMoneyline
DraftKingsSF -2.5 49.5 o -115 / u -105 San Francisco 49ers -142 · Atlanta Falcons +120

What these prices pay on $100 · What these numbers mean

Injury report

  • Avieon TerrellOutBackAtlanta Falcons
  • Jack StrandOutCoach's DecisionAtlanta Falcons
  • Andy DaltonOutCoach's DecisionAtlanta Falcons
  • Olamide ZaccheausOutShoulderAtlanta Falcons
  • Brian Robinson Jr.OutHamstringAtlanta Falcons
  • Deebo Samuel Sr.OutHamstringSan Francisco 49ers
  • Marques SigleOutAnkleSan Francisco 49ers
  • Garret WallowOutHamstringSan Francisco 49ers
  • Kurtis RourkeOutCoach's DecisionSan Francisco 49ers
  • Luke GiffordOutGroinSan Francisco 49ers

Leaders

  • Passing yardsMichael Penix Jr.25/34, 213 YDS, 3 TDAtlanta Falcons
  • Rushing yardsBijan Robinson20 CAR, 63 YDSAtlanta Falcons
  • Receiving yardsDrake London7 REC, 66 YDS, 1 TDAtlanta Falcons
  • Passing yardsBrock Purdy27/40, 288 YDS, 1 TD, 2 INTSan Francisco 49ers
  • Rushing yardsKaelon Black12 CAR, 63 YDS, 1 TDSan Francisco 49ers
  • Receiving yardsGeorge Kittle8 REC, 88 YDSSan Francisco 49ers

Recent form

Atlanta Falcons

Last 10: 6-4Streak L224.3 scored · 24.1 allowed per game2-3 at home

  • L23-31vs Chicago BearsOct 18
  • L23-30vs Baltimore RavensOct 12
  • W45-24at New Orleans SaintsOct 6
  • W35-14at Green Bay PackersSep 25
  • L3-34vs Carolina PanthersSep 20
  • L13-20at Pittsburgh SteelersSep 13
  • W19-17vs New Orleans SaintsJan 4
  • W27-24vs Los Angeles RamsDec 30
  • W26-19at Arizona CardinalsDec 21
  • W29-28at Tampa Bay BuccaneersDec 12

San Francisco 49ers

Last 10: 9-1Streak W630.7 scored · 21.2 allowed per game3-0 away

  • W23-17vs Washington CommandersOct 20
  • W32-29at Seattle SeahawksOct 11
  • W24-14vs Denver BroncosOct 4
  • W36-30vs Arizona CardinalsSep 27
  • W35-13vs Miami DolphinsSep 20
  • W27-7at Los Angeles RamsSep 11
  • L3-13vs Seattle SeahawksJan 4
  • W42-38vs Chicago BearsDec 29
  • W48-27at Indianapolis ColtsDec 23
  • W37-24vs Tennessee TitansDec 14

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
San Francisco11391970.85766-1
Seattle31221480.50033-3
Arizona41781260.33322-4
Los Angeles41381350.33322-4
Carolina31661590.50033-3
Atlanta41731710.42933-4
Tampa Bay51511620.28622-5
New Orleans51941620.28622-5

Box score

StatSan Francisco 49ersAtlanta Falcons
First downs2621
First downs passing1711
First downs rushing76
First downs by penalty24
Third downs4-104-12
Fourth downs3-40-0
Offensive plays6563
Total yards400295
Yards per play6.24.7
Drives910
Net passing yards277213
Completions27/4025/34
Yards per pass6.66.3
Interceptions thrown20
Sacks allowed2-110-0
Rushing yards12382
Rushing attempts2329
Yards per rush5.32.8
Red zone trips2-22-5
Penalties7-555-39
Turnovers40
Fumbles lost20
Defensive touchdowns00
Time of possession29:1330:47

Win probability

Above the line favours Atlanta Falcons, below favours San Francisco 49ers.

Venue

  • Mercedes-Benz StadiumAtlanta, GA
  • Attendance72165
  • OfficialsGreg Wilson, Clay Martin, Eugene Hall, Steven Woods, Jerod Phillips, Brian Perry, Sean Woodson

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.