49ers Dominate Colts in High-Scoring Contest
Monday, December 22, 2025, 8:15 PM ET · Lucas Oil Stadium
San Francisco 49ers 48, Indianapolis Colts 27, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.
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Quick answers
Who won San Francisco 49ers vs Indianapolis Colts?
San Francisco 49ers beat Indianapolis Colts 48-27 at Lucas Oil Stadium on December 22, 2025.
Who was favored in San Francisco 49ers vs Indianapolis Colts?
San Francisco 49ers were the favorite at DraftKings, moneyline -225 (about 69% implied). The favorite won.
In a decisive victory, the San Francisco 49ers defeated the Indianapolis Colts 48-27 at Lucas Oil Stadium. The 49ers, boasting an impressive away record of 11-4, continued their strong performance, extending their winning streak to five games. In contrast, the Colts fell to 8-8, having lost their last five games, marking a significant downturn in form.
The Colts entered the matchup struggling, with a recent record of 5-5 over their last ten games, and they had averaged 26.9 points scored while allowing 22.0 points per game. Their last five games showed a troubling trend, with an average of only 20.4 points scored and 24.4 points allowed. The Colts' home record stood at 4-1, but their away performances had been less favorable, with a 1-4 record in away games. The 49ers, on the other hand, had been in fine form, winning 7 of their last 10 games and averaging 26.4 points scored against 21.8 points allowed. Their last five games had seen them score an impressive average of 30.0 points while allowing just 21.0 points.
In terms of previous meetings, this matchup was particularly noteworthy due to the contrasting recent performances of both teams. The 49ers had been riding high on a four-game winning streak, which included a convincing 37-24 victory against the Tennessee Titans in their last outing. The Colts, however, had been unable to find their footing, suffering a narrow 18-16 loss to the Seattle Seahawks just a week prior.
Injuries played a role in the matchup, particularly for the Colts, who had several key players listed as questionable, including A.J. Haulcy, Alec Pierce, Tyler Warren, and Josh Downs, all dealing with various ailments. Additionally, Coleman Owen was on injured reserve with a concussion. The 49ers also faced injury concerns, with Sam Okuayinonu, Kyle Juszczyk, Nick Bosa, Mike Evans, and George Kittle all listed as questionable.
The betting market reflected the 49ers' strong form, with DraftKings pricing them as 4.5-point favorites. The total for the game was set at 46.5, indicating expectations for a high-scoring affair. The odds for the 49ers to win straight up were -225, while the Colts were at +185.
Conditions at Lucas Oil Stadium were conducive to an exciting game, with both teams looking to capitalize on their offensive strengths. Viewers were treated to a display of offensive prowess from the 49ers, who consistently found ways to exploit the Colts' defense. The Colts, despite their struggles, managed to put up a respectable score, but it was clear that the 49ers were in control throughout the game.
Overall, the matchup highlighted the stark contrast in form and performance between the two teams, with the 49ers solidifying their position as a formidable contender in the league while the Colts faced a challenging path ahead.
Odds
| Book | Spread | Total | Moneyline |
|---|---|---|---|
| DraftKings | SF -4.5 | 46.5 o -102 / u -118 | San Francisco 49ers -225 · Indianapolis Colts +185 |
Injury report
- A.J. HaulcyQuestionableAnkleIndianapolis Colts
- Alec PierceQuestionableAnkleIndianapolis Colts
- Tyler WarrenQuestionableGroinIndianapolis Colts
- Josh DownsQuestionableCalfIndianapolis Colts
- Coleman OwenInjured ReserveConcussionIndianapolis Colts
- Sam OkuayinonuQuestionableFootSan Francisco 49ers
- Kyle JuszczykQuestionableFingerSan Francisco 49ers
- Nick BosaQuestionableKnee - ACLSan Francisco 49ers
- Mike EvansQuestionableGroinSan Francisco 49ers
- George KittleQuestionableAchillesSan Francisco 49ers
Leaders
- Passing yardsPhilip Rivers23/35, 277 YDS, 2 TD, 1 INTIndianapolis Colts
- Rushing yardsJonathan Taylor16 CAR, 46 YDS, 1 TDIndianapolis Colts
- Receiving yardsAlec Pierce4 REC, 86 YDS, 2 TDIndianapolis Colts
- Passing yardsBrock Purdy25/34, 295 YDS, 5 TD, 1 INTSan Francisco 49ers
- Rushing yardsChristian McCaffrey21 CAR, 117 YDSSan Francisco 49ers
- Receiving yardsGeorge Kittle7 REC, 115 YDS, 1 TDSan Francisco 49ers
Recent form
Indianapolis Colts
Last 10: 5-5Streak L426.9 scored · 22 allowed per game4-1 at home
- L16-18at Seattle SeahawksDec 14
- L19-36at Jacksonville JaguarsDec 7
- L16-20vs Houston TexansNov 30
- L20-23at Kansas City ChiefsNov 23
- W31-25vs Atlanta FalconsNov 9
- L20-27at Pittsburgh SteelersNov 2
- W38-14vs Tennessee TitansOct 26
- W38-24at Los Angeles ChargersOct 19
- W31-27vs Arizona CardinalsOct 12
- W40-6vs Las Vegas RaidersOct 5
San Francisco 49ers
Last 10: 7-3Streak W426.4 scored · 21.8 allowed per game4-2 away
- W37-24vs Tennessee TitansDec 14
- W26-8at Cleveland BrownsNov 30
- W20-9vs Carolina PanthersNov 25
- W41-22at Arizona CardinalsNov 16
- L26-42vs Los Angeles RamsNov 9
- W34-24at New York GiantsNov 2
- L15-26at Houston TexansOct 26
- W20-10vs Atlanta FalconsOct 20
- L19-30at Tampa Bay BuccaneersOct 12
- W26-23at Los Angeles RamsOct 3
Standings
| Team | Lost | Points against | Points for | Tied | Win % | Won | Overall |
|---|---|---|---|---|---|---|---|
| Los Angeles | 0 | 30 | 74 | 0 | 1.000 | 3 | 3-0 |
| San Francisco | 1 | 48 | 72 | 0 | .667 | 2 | 2-1 |
| Arizona | 3 | 123 | 108 | 0 | .250 | 1 | 1-3 |
| Seattle | 2 | 45 | 32 | 1 | .167 | 0 | 0-2-1 |
| Jacksonville | 1 | 54 | 60 | 0 | .667 | 2 | 2-1 |
| Tennessee | 1 | 53 | 53 | 0 | .667 | 2 | 2-1 |
| Indianapolis | 2 | 72 | 35 | 1 | .167 | 0 | 0-2-1 |
| Houston | 3 | 65 | 40 | 0 | .000 | 0 | 0-3 |
Box score
| Stat | San Francisco 49ers | Indianapolis Colts |
|---|---|---|
| First downs | 28 | 19 |
| First downs passing | 20 | 13 |
| First downs rushing | 8 | 4 |
| First downs by penalty | 0 | 2 |
| Third downs | 7-11 | 5-10 |
| Fourth downs | 1-1 | 0-1 |
| Offensive plays | 66 | 58 |
| Total yards | 440 | 312 |
| Yards per play | 6.7 | 5.4 |
| Drives | 10 | 10 |
| Net passing yards | 295 | 254 |
| Completions | 25/34 | 23/36 |
| Yards per pass | 8.4 | 6.7 |
| Interceptions thrown | 1 | 1 |
| Sacks allowed | 1-0 | 2-23 |
| Rushing yards | 145 | 58 |
| Rushing attempts | 31 | 20 |
| Yards per rush | 4.7 | 2.9 |
| Red zone trips | 4-6 | 2-2 |
| Penalties | 2-36 | 6-45 |
| Turnovers | 1 | 2 |
| Fumbles lost | 0 | 1 |
| Defensive touchdowns | 1 | 0 |
| Time of possession | 33:05 | 26:55 |
Win probability
Above the line favours Indianapolis Colts, below favours San Francisco 49ers.
Venue
- Lucas Oil StadiumIndianapolis, IN
- Attendance66265
- OfficialsBarry Anderson, Ronald Torbert, Keith Washington, Ryan Dickson, Brian Bolinger, Frank LeBlanc, Courtney Brown
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