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NFL · Final

49ers Dominate Chargers with 41-17 Victory

Thursday, August 20, 2026, 10:00 PM ET · SoFi Stadium

San Francisco 49ers 41, Los Angeles Chargers 17, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won San Francisco 49ers vs Los Angeles Chargers?

San Francisco 49ers beat Los Angeles Chargers 41-17 at SoFi Stadium on August 20, 2026.

Who was favored in San Francisco 49ers vs Los Angeles Chargers?

Los Angeles Chargers were the favorite at DraftKings, moneyline -125 (about 56% implied). The underdog won.

The San Francisco 49ers delivered a commanding performance against the Los Angeles Chargers, winning 41-17 at SoFi Stadium. This matchup highlighted the contrasting fortunes of both teams, with the 49ers showcasing their offensive prowess while the Chargers struggled to keep pace.

Both teams entered the game with a record of 1-1, but the 49ers had been on a downward trajectory, losing their last two games prior to this matchup. In their last ten games, the 49ers had a record of 7-3, averaging 29.0 points scored and allowing 22.6 points per game. In contrast, the Chargers had a similar record of 7-3 over the same span, but their scoring average was lower at 20.7 points, with 17.4 points allowed. The Chargers had been more effective at home, boasting a home record of 3-1, while the 49ers had a solid away record of 4-0.

The game kicked off under favorable conditions, and the 49ers quickly established control. The Chargers were unable to find their rhythm, and their struggles were compounded by a series of injuries affecting key players. For the Chargers, Keaton Mitchell was listed as questionable, while Denzel Perryman, Kyle Kennard, Dalevon Campbell, and Isaiah World were all on injured reserve, with World ruled out due to a knee injury. The 49ers also faced injury challenges, with Sam Okuayinonu ruled out due to a foot injury, while Kyle Juszczyk, Nick Bosa, Mike Evans, and George Kittle were all listed as questionable.

The betting market reflected the expectations for this game, with DraftKings setting the spread at LAC -1.5 and a total of 38.5 points. The Chargers were favored to win at -125 on the moneyline, while the 49ers were priced at 105.

Throughout the game, the 49ers demonstrated their offensive capabilities, effectively utilizing their playmakers to build a commanding lead. The Chargers, despite their best efforts, could not mount a significant comeback. The final score of 41-17 underscored the 49ers' dominance in this matchup, as they capitalized on the Chargers' mistakes and exploited their defensive weaknesses.

As the game concluded, the Chargers faced a critical juncture in their season, needing to regroup and address the issues that led to their defeat, while the 49ers celebrated a much-needed victory to regain momentum.

Odds

BookSpreadTotalMoneyline
DraftKingsLAC -1.5 38.5 o -110 / u -110 San Francisco 49ers +105 · Los Angeles Chargers -125

What these prices pay on $100 · What these numbers mean

Injury report

  • Keaton MitchellQuestionableUndisclosedLos Angeles Chargers
  • Denzel PerrymanInjured ReserveUndisclosedLos Angeles Chargers
  • Kyle KennardInjured ReserveUndisclosedLos Angeles Chargers
  • Dalevon CampbellInjured ReserveLegLos Angeles Chargers
  • Isaiah WorldOutKneeLos Angeles Chargers
  • Sam OkuayinonuOutFootSan Francisco 49ers
  • Kyle JuszczykQuestionableFingerSan Francisco 49ers
  • Nick BosaQuestionableKnee - ACLSan Francisco 49ers
  • Mike EvansQuestionableGroinSan Francisco 49ers
  • George KittleQuestionableAchillesSan Francisco 49ers

Leaders

  • Passing yardsDJ Uiagalelei7/15, 80 YDS, 1 TDLos Angeles Chargers
  • Rushing yardsTrey Lance2 CAR, 42 YDSLos Angeles Chargers
  • Receiving yardsJerand Bradley1 REC, 28 YDS, 1 TDLos Angeles Chargers
  • Passing yardsMac Jones6/13, 89 YDSSan Francisco 49ers
  • Rushing yardsSincere McCormick6 CAR, 53 YDS, 1 TDSan Francisco 49ers
  • Receiving yardsKhaDarel Hodge4 REC, 46 YDSSan Francisco 49ers

Recent form

Los Angeles Chargers

Last 10: 7-3Streak W120.7 scored · 17.4 allowed per game3-1 at home

  • W27-7at Houston TexansAug 14
  • L3-19at Denver BroncosJan 4
  • L16-20vs Houston TexansDec 27
  • W34-17at Dallas CowboysDec 21
  • W16-13at Kansas City ChiefsDec 14
  • W22-19vs Philadelphia EaglesDec 9
  • W31-14vs Las Vegas RaidersNov 30
  • L6-35at Jacksonville JaguarsNov 16
  • W25-10vs Pittsburgh SteelersNov 10
  • W27-20at Tennessee TitansNov 2

San Francisco 49ers

Last 10: 7-3Streak L229 scored · 22.6 allowed per game4-0 away

  • L13-19vs Tennessee TitansAug 14
  • L3-13vs Seattle SeahawksJan 4
  • W42-38vs Chicago BearsDec 29
  • W48-27at Indianapolis ColtsDec 23
  • W37-24vs Tennessee TitansDec 14
  • W26-8at Cleveland BrownsNov 30
  • W20-9vs Carolina PanthersNov 25
  • W41-22at Arizona CardinalsNov 16
  • L26-42vs Los Angeles RamsNov 9
  • W34-24at New York GiantsNov 2

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1
Denver146740.66722-1
Los Angeles268620.33311-2
Las Vegas265480.33311-2
Kansas City245361.16700-2-1

Box score

StatSan Francisco 49ersLos Angeles Chargers
First downs208
First downs passing106
First downs rushing82
First downs by penalty20
Third downs6-162-14
Fourth downs1-11-3
Offensive plays7254
Total yards321229
Yards per play4.54.2
Drives1413
Net passing yards175161
Completions18/3618/33
Yards per pass4.94.7
Interceptions thrown20
Sacks allowed0-01-1
Rushing yards14668
Rushing attempts3620
Yards per rush4.13.4
Red zone trips4-40-1
Penalties6-417-47
Turnovers21
Fumbles lost01
Defensive touchdowns11
Time of possession32:5627:04

Win probability

Above the line favours Los Angeles Chargers, below favours San Francisco 49ers.

Venue

  • SoFi StadiumInglewood, CA
  • Attendance62156
  • OfficialsMax Causey, Frank Steratore, Craig Wrolstad, Rich Martinez, Brandon Cruse, Jeff Shears, John Braun

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.