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NFL · Final

49ers Edge Saints in Close Contest at Caesars Superdome

Sunday, September 14, 2025, 1:00 PM ET · Caesars Superdome

San Francisco 49ers 26, New Orleans Saints 21, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won San Francisco 49ers vs New Orleans Saints?

San Francisco 49ers beat New Orleans Saints 26-21 at Caesars Superdome on September 14, 2025.

In a tightly contested matchup at Caesars Superdome, the San Francisco 49ers emerged victorious against the New Orleans Saints, finishing the game with a score of 26-21. This result marks a continuation of the Saints' struggles, as they have now lost five consecutive games, while the 49ers improved to a 2-0 record on the road this season.

The Saints entered the game with a home record of 0-2 and a troubling recent form, having lost their last five games with an average of just 12.2 points scored and 25.2 points allowed over that span. Their overall record in the last ten games stands at 3-7, with an average of 16.6 points scored and 21.2 points allowed. The last time they played at home, they fell to the Arizona Cardinals with a score of 13-20. Their home performance this season has been particularly disappointing, as they have only managed to win 2 of their last 6 home games.

On the other hand, the 49ers have shown resilience, winning their last game against the Seattle Seahawks 17-13, and they now hold a record of 3-7 over their last ten games. Their scoring average is slightly higher than the Saints at 19.6 points per game, but they have also been allowing more points, averaging 26.7 points against. The 49ers' away record stands at 2-4, indicating that while they have struggled on the road, they have managed to secure key victories.

In terms of injuries, the Saints faced significant challenges with several players on the injury report. Kendre Miller was listed as questionable with an undisclosed issue, while Lorenzo Styles Jr., Michael Heldman, Jaylan Ford, and David Long Jr. were all placed on injured reserve. The 49ers also had notable injuries, with Sam Okuayinonu, Kyle Juszczyk, Nick Bosa, Mike Evans, and George Kittle all listed as questionable, which could have impacted their performance.

The betting market reflected the competitive nature of this matchup, with the odds indicating a close game. The 49ers were favored to win, reflecting their recent form and overall performance. The exact odds were not provided, but the market suggested a clear expectation of a challenging contest.

Conditions during the game were typical for a late summer evening in New Orleans, with warm temperatures expected to influence the pace of play. Fans in attendance were treated to an exciting atmosphere as both teams battled for supremacy.

Viewers should have kept an eye on the performance of key players, particularly the quarterbacks and running backs, as their contributions would likely be pivotal in determining the outcome. Additionally, the effectiveness of the defenses in stopping big plays would be crucial, especially given the scoring averages of both teams.

Ultimately, the game showcased the competitive spirit of the NFL, with the 49ers continuing their winning ways while the Saints look to regroup and address their ongoing struggles.

Injury report

  • Kendre MillerQuestionableUndisclosedNew Orleans Saints
  • Lorenzo Styles Jr.Injured ReserveCalfNew Orleans Saints
  • Michael HeldmanInjured ReserveUndisclosedNew Orleans Saints
  • Jaylan FordInjured ReserveUndisclosedNew Orleans Saints
  • David Long Jr.Injured ReserveUndisclosedNew Orleans Saints
  • Sam OkuayinonuQuestionableFootSan Francisco 49ers
  • Kyle JuszczykQuestionableFingerSan Francisco 49ers
  • Nick BosaQuestionableKnee - ACLSan Francisco 49ers
  • Mike EvansQuestionableGroinSan Francisco 49ers
  • George KittleQuestionableAchillesSan Francisco 49ers

Leaders

  • Passing yardsSpencer Rattler25/34, 207 YDS, 3 TDNew Orleans Saints
  • Rushing yardsAlvin Kamara21 CAR, 99 YDSNew Orleans Saints
  • Receiving yardsChris Olave6 REC, 54 YDSNew Orleans Saints
  • Passing yardsMac Jones26/39, 279 YDS, 3 TDSan Francisco 49ers
  • Rushing yardsChristian McCaffrey13 CAR, 55 YDSSan Francisco 49ers
  • Receiving yardsJauan Jennings5 REC, 89 YDS, 1 TDSan Francisco 49ers

Recent form

New Orleans Saints

Last 10: 3-7Streak L516.6 scored · 21.2 allowed per game2-4 at home

  • L13-20vs Arizona CardinalsSep 7
  • L19-27at Tampa Bay BuccaneersJan 5
  • L10-25vs Las Vegas RaidersDec 29
  • L0-34at Green Bay PackersDec 24
  • L19-20vs Washington CommandersDec 15
  • W14-11at New York GiantsDec 8
  • L14-21vs Los Angeles RamsDec 1
  • W35-14vs Cleveland BrownsNov 17
  • W20-17vs Atlanta FalconsNov 10
  • L22-23at Carolina PanthersNov 3

San Francisco 49ers

Last 10: 3-7Streak W119.6 scored · 26.7 allowed per game2-4 away

  • W17-13at Seattle SeahawksSep 7
  • L24-47at Arizona CardinalsJan 5
  • L34-40vs Detroit LionsDec 31
  • L17-29at Miami DolphinsDec 22
  • L6-12vs Los Angeles RamsDec 13
  • W38-13vs Chicago BearsDec 8
  • L10-35at Buffalo BillsDec 2
  • L10-38at Green Bay PackersNov 24
  • L17-20vs Seattle SeahawksNov 17
  • W23-20at Tampa Bay BuccaneersNov 10

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1
Carolina189970.75033-1
Tampa Bay150400.66722-1
Atlanta145580.66722-1
New Orleans282470.33311-2

Box score

StatSan Francisco 49ersNew Orleans Saints
First downs2321
First downs passing1512
First downs rushing56
First downs by penalty33
Third downs8-154-11
Fourth downs0-01-2
Offensive plays6867
Total yards344307
Yards per play5.14.6
Drives1111
Net passing yards267186
Completions26/3925/34
Yards per pass6.45.0
Interceptions thrown00
Sacks allowed3-123-21
Rushing yards77121
Rushing attempts2630
Yards per rush3.04.0
Red zone trips2-23-3
Penalties5-407-45
Turnovers11
Fumbles lost11
Defensive touchdowns00
Time of possession30:4529:15

Win probability

Above the line favours New Orleans Saints, below favours San Francisco 49ers.

Venue

  • Caesars SuperdomeNew Orleans, LA
  • Attendance70078
  • OfficialsDino Paganelli, Dyrol Prioleau, Jeff Seeman, Boris Cheek, Shawn Smith, Tra Blake, Jay Bilbo

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.