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NFL · Final

Titans Edge Cardinals in Nail-Biter Finish

Sunday, October 5, 2025, 4:05 PM ET · State Farm Stadium

Tennessee Titans 22, Arizona Cardinals 21, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Tennessee Titans vs Arizona Cardinals?

Tennessee Titans beat Arizona Cardinals 22-21 at State Farm Stadium on October 5, 2025.

In a closely contested game at State Farm Stadium, the Tennessee Titans narrowly defeated the Arizona Cardinals with a final score of 22-21. This matchup was particularly significant as it featured two teams struggling to find their footing in the NFL, with the Titans coming into the game with a 1-4 record and the Cardinals at 2-3. The Titans' victory marked a much-needed win, breaking a streak of ten consecutive losses, while the Cardinals continued their downward trend, now having lost their last three games.

The Cardinals' recent form had been concerning, as they entered the game on a two-game losing streak, having lost to the Seattle Seahawks (20-23) and the San Francisco 49ers (15-16). Their average scoring over the last ten games was 23.8 points, while they allowed an average of 21.7 points. At home, they had a record of 3-2, but their last five games showed a slight improvement with an average of 25.8 points scored and 19.6 points allowed.

On the other hand, the Titans were in a dire situation, having lost their last ten games, with an average of only 16.0 points scored and a staggering 29.0 points allowed during that stretch. Their away record stood at 0-5, and they had not won a game since their season opener. The Titans' last five games reflected their struggles, with an average of 13.0 points scored and 28.6 points allowed.

In terms of home and away performance, the Cardinals had shown some resilience at home, but the Titans had been unable to secure a win on the road. This game was critical for both teams, as they sought to turn their seasons around.

Injuries also played a role in the game. The Cardinals had several key players listed on the injury report, including Jeremiyah Love and Will Johnson, both of whom were questionable due to ankle and lower body injuries, respectively. Additionally, James Conner was on Injured Reserve with a foot injury, further impacting the Cardinals' offensive capabilities. For the Titans, Carnell Tate and Andre James were both listed as questionable, while several players, including Kendell Brooks and Tanoh Kpassagnon, were on Injured Reserve, limiting their depth.

The betting market indicated a challenging outlook for the Cardinals, with a home win probability of 0.0 according to the latest odds. This reflected the struggles both teams faced, but particularly highlighted the Titans' desperate need for a win.

Conditions at State Farm Stadium were typical for a fall evening, with clear skies and moderate temperatures, providing an ideal setting for football. Fans were treated to a competitive atmosphere as both teams fought hard for every yard.

As the game unfolded, viewers were encouraged to watch for the Titans' ability to capitalize on the Cardinals' defensive lapses, as well as the Cardinals' attempts to leverage their home-field advantage despite their recent struggles. The Titans' victory not only provided them with a much-needed boost but also left the Cardinals searching for answers as they look to rebound from their current form.

Injury report

  • Jeremiyah LoveQuestionableAnkleArizona Cardinals
  • Zachary CarterInjured ReserveKneeArizona Cardinals
  • Will JohnsonQuestionableLower BodyArizona Cardinals
  • Tip ReimanOutAnkleArizona Cardinals
  • James ConnerInjured ReserveFootArizona Cardinals
  • Carnell TateQuestionableUndisclosedTennessee Titans
  • Kendell BrooksInjured ReserveUndisclosedTennessee Titans
  • Andre JamesQuestionableUndisclosedTennessee Titans
  • Tanoh KpassagnonInjured ReserveUndisclosedTennessee Titans
  • Dorian MausiInjured ReserveUndisclosedTennessee Titans

Leaders

  • Passing yardsKyler Murray23/31, 220 YDSArizona Cardinals
  • Rushing yardsEmari Demercado3 CAR, 81 YDSArizona Cardinals
  • Receiving yardsMarvin Harrison Jr.4 REC, 98 YDSArizona Cardinals
  • Passing yardsCam Ward21/39, 265 YDS, 1 INTTennessee Titans
  • Rushing yardsTony Pollard14 CAR, 67 YDS, 1 TDTennessee Titans
  • Receiving yardsCalvin Ridley5 REC, 131 YDSTennessee Titans

Recent form

Arizona Cardinals

Last 10: 4-6Streak L223.8 scored · 21.7 allowed per game3-2 at home

  • L20-23vs Seattle SeahawksSep 26
  • L15-16at San Francisco 49ersSep 21
  • W27-22vs Carolina PanthersSep 14
  • W20-13at New Orleans SaintsSep 7
  • W47-24vs San Francisco 49ersJan 5
  • L9-13at Los Angeles RamsDec 29
  • L30-36at Carolina PanthersDec 22
  • W30-17vs New England PatriotsDec 15
  • L18-30vs Seattle SeahawksDec 8
  • L22-23at Minnesota VikingsDec 1

Tennessee Titans

Last 10: 0-10Streak L1016 scored · 29 allowed per game0-5 away

  • L0-26at Houston TexansSep 28
  • L20-41vs Indianapolis ColtsSep 21
  • L19-33vs Los Angeles RamsSep 14
  • L12-20at Denver BroncosSep 7
  • L14-23vs Houston TexansJan 5
  • L13-20at Jacksonville JaguarsDec 29
  • L30-38at Indianapolis ColtsDec 22
  • L27-37vs Cincinnati BengalsDec 15
  • L6-10vs Jacksonville JaguarsDec 8
  • L19-42at Washington CommandersDec 1

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Jacksonville154600.66722-1
Tennessee153530.66722-1
Indianapolis272351.16700-2-1
Houston365400.00000-3
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1

Box score

StatTennessee TitansArizona Cardinals
First downs2016
First downs passing128
First downs rushing67
First downs by penalty21
Third downs5-157-16
Fourth downs0-10-0
Offensive plays6564
Total yards327360
Yards per play5.05.6
Drives1312
Net passing yards249192
Completions21/3923/32
Yards per pass6.15.5
Interceptions thrown10
Sacks allowed2-163-28
Rushing yards78168
Rushing attempts2429
Yards per rush3.35.8
Red zone trips1-23-4
Penalties6-358-47
Turnovers23
Fumbles lost13
Defensive touchdowns00
Time of possession27:2032:40

Win probability

Above the line favours Arizona Cardinals, below favours Tennessee Titans.

Venue

  • State Farm StadiumGlendale, AZ
  • Attendance64280
  • OfficialsDino Paganelli, Dyrol Prioleau, Jeff Seeman, Boris Cheek, Shawn Smith, Tra Blake, Jay Bilbo

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.