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NFL · Final

49ers Defeat Titans 37-24 at Levi's Stadium

Sunday, December 14, 2025, 4:25 PM ET · Levi's Stadium

San Francisco 49ers 37, Tennessee Titans 24, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Tennessee Titans vs San Francisco 49ers?

San Francisco 49ers beat Tennessee Titans 37-24 at Levi's Stadium on December 14, 2025.

Who was favored in Tennessee Titans vs San Francisco 49ers?

San Francisco 49ers were the favorite at DraftKings, moneyline -950 (about 90% implied). The favorite won.

The San Francisco 49ers secured a convincing 37-24 victory over the Tennessee Titans at Levi's Stadium, showcasing their strength as they continue to push for a strong finish to the season. This win marks the 49ers' fourth consecutive victory, improving their record to 11-4, while the Titans fall to 2-13, highlighting the stark contrast in their seasons.

In recent form, the 49ers have been on a roll, winning six of their last ten games with a record of 6-4. They have averaged 24.8 points scored per game while allowing 22.0 points. Their last five games have seen them perform even better, with an average of 29.4 points scored and only 21.0 points allowed. The Titans, on the other hand, have struggled significantly, with a record of 2-8 in their last ten games. They have averaged just 15.0 points scored per game, while their defense has allowed an average of 26.3 points. Their recent form shows a slight improvement with a win in their last game, but the overall trend remains concerning.

At home, the 49ers have a record of 2-2, while they have excelled on the road with a 4-2 record. The Titans have not found success away from home, holding a 0-5 record in their last five road games. This matchup was particularly noteworthy as the Titans have struggled throughout the season, while the 49ers have been a formidable opponent, especially at home.

The two teams have faced each other previously, but the specifics of those encounters were not detailed in the provided information. However, the current season's context clearly indicates a dominant performance by the 49ers.

In terms of injuries, the 49ers had several players listed as questionable, including Sam Okuayinonu (foot), Kyle Juszczyk (finger), Nick Bosa (knee - ACL), Mike Evans (groin), and George Kittle (Achilles). For the Titans, Carnell Tate was also questionable with an undisclosed injury, while Kendell Brooks, Tanoh Kpassagnon, and Dorian Mausi were on injured reserve with undisclosed injuries. The impact of these injuries could have played a role in the game, particularly for the 49ers, who have key players dealing with health issues.

The betting market reflected the 49ers' dominance, with DraftKings listing them as 12.5-point favorites. The total for the game was set at 44.5, with odds of -112.0 for the over and -108.0 for the under. The moneyline indicated a strong belief in a 49ers victory, priced at -950.0 for the home team, while the Titans were listed at 625.0.

Conditions at Levi's Stadium were not specified in the block, but the home field advantage typically plays a significant role in NFL matchups. Fans watching the game would have seen a 49ers team that was efficient on offense and solid on defense, capitalizing on the Titans' struggles.

Overall, this game highlighted the disparity between the two teams in terms of current form, injuries, and home-field advantage, culminating in a decisive victory for the 49ers.

Odds

BookSpreadTotalMoneyline
DraftKingsSF -12.5 44.5 o -112 / u -108 Tennessee Titans +625 · San Francisco 49ers -950

What these prices pay on $100 · What these numbers mean

Injury report

  • Sam OkuayinonuQuestionableFootSan Francisco 49ers
  • Kyle JuszczykQuestionableFingerSan Francisco 49ers
  • Nick BosaQuestionableKnee - ACLSan Francisco 49ers
  • Mike EvansQuestionableGroinSan Francisco 49ers
  • George KittleQuestionableAchillesSan Francisco 49ers
  • Carnell TateQuestionableUndisclosedTennessee Titans
  • Kendell BrooksInjured ReserveUndisclosedTennessee Titans
  • Andre JamesQuestionableUndisclosedTennessee Titans
  • Tanoh KpassagnonInjured ReserveUndisclosedTennessee Titans
  • Dorian MausiInjured ReserveUndisclosedTennessee Titans

Leaders

  • Passing yardsBrock Purdy23/30, 295 YDS, 3 TDSan Francisco 49ers
  • Rushing yardsChristian McCaffrey22 CAR, 73 YDS, 1 TDSan Francisco 49ers
  • Receiving yardsRicky Pearsall6 REC, 96 YDSSan Francisco 49ers
  • Passing yardsCam Ward18/29, 170 YDS, 2 TDTennessee Titans
  • Rushing yardsTony Pollard14 CAR, 104 YDS, 1 TDTennessee Titans
  • Receiving yardsGunnar Helm4 REC, 49 YDS, 1 TDTennessee Titans

Recent form

San Francisco 49ers

Last 10: 6-4Streak W324.8 scored · 22 allowed per game2-2 at home

  • W26-8at Cleveland BrownsNov 30
  • W20-9vs Carolina PanthersNov 25
  • W41-22at Arizona CardinalsNov 16
  • L26-42vs Los Angeles RamsNov 9
  • W34-24at New York GiantsNov 2
  • L15-26at Houston TexansOct 26
  • W20-10vs Atlanta FalconsOct 20
  • L19-30at Tampa Bay BuccaneersOct 12
  • W26-23at Los Angeles RamsOct 3
  • L21-26vs Jacksonville JaguarsSep 28

Tennessee Titans

Last 10: 2-8Streak W115 scored · 26.3 allowed per game2-3 away

  • W31-29at Cleveland BrownsDec 7
  • L3-25vs Jacksonville JaguarsNov 30
  • L24-30vs Seattle SeahawksNov 23
  • L13-16vs Houston TexansNov 16
  • L20-27vs Los Angeles ChargersNov 2
  • L14-38at Indianapolis ColtsOct 26
  • L13-31vs New England PatriotsOct 19
  • L10-20at Las Vegas RaidersOct 12
  • W22-21at Arizona CardinalsOct 5
  • L0-26at Houston TexansSep 28

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Jacksonville154600.66722-1
Tennessee153530.66722-1
Indianapolis272351.16700-2-1
Houston365400.00000-3
Los Angeles0307401.00033-0
San Francisco148720.66722-1
Arizona31231080.25011-3
Seattle245321.16700-2-1

Box score

StatTennessee TitansSan Francisco 49ers
First downs1828
First downs passing818
First downs rushing97
First downs by penalty13
Third downs3-99-15
Fourth downs2-21-1
Offensive plays4970
Total yards306430
Yards per play6.26.1
Drives98
Net passing yards170292
Completions18/2923/30
Yards per pass5.99.1
Interceptions thrown00
Sacks allowed0-02-3
Rushing yards136138
Rushing attempts2038
Yards per rush6.83.6
Red zone trips2-34-6
Penalties7-576-30
Turnovers01
Fumbles lost01
Defensive touchdowns00
Time of possession22:5537:05

Win probability

Above the line favours San Francisco 49ers, below favours Tennessee Titans.

Venue

  • Levi's StadiumSanta Clara, CA
  • Attendance71042
  • OfficialsFrank Steratore, Craig Wrolstad, Rich Martinez, Danny Short, Brandon Cruse, Jeff Shears, Brett Bergman

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.