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NFL · Final

Bills Dominate Panthers in Convincing Win

Sunday, October 26, 2025, 1:00 PM ET · Bank of America Stadium

Buffalo Bills 40, Carolina Panthers 9, final. Our NFL picks are sealed as a hash before kickoff and settled in public, losses included.

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Quick answers

Who won Buffalo Bills vs Carolina Panthers?

Buffalo Bills beat Carolina Panthers 40-9 at Bank of America Stadium on October 26, 2025.

The Buffalo Bills delivered a commanding performance against the Carolina Panthers, winning decisively with a final score of 40-9. This matchup, held at Bank of America Stadium, showcased the Bills' offensive prowess and the Panthers' struggles, particularly in the second half. The Bills improved their record to 6-2, while the Panthers fell to 4-5.

Entering the game, the Bills had a strong away record of 5-2, although they were on a two-game losing streak. Their recent form included a record of 7-3 over the last ten games, with an average of 29.5 points scored and 23.7 points allowed. In contrast, the Panthers had been performing well at home, boasting a perfect 4-0 home record and a three-game winning streak leading up to this game. However, their overall record of 4-4 indicated inconsistency, with an average of 23.9 points scored and 26.8 points allowed.

The Panthers had faced a series of injuries that impacted their lineup. Key players such as Jonathon Brooks and Chuba Hubbard were listed as questionable due to general soreness and hamstring issues, respectively. Additionally, Brady Christensen, Ryan Hayes, and Bam Martin-Scott were on injured reserve, further complicating the Panthers' depth. The Bills also had injuries to contend with, including Khalil Shakir, Keon Coleman, and Ty Johnson, all of whom were questionable, while Tyrell Shavers was ruled out due to an ACL injury.

The conditions for the game were typical for late October, with the weather likely impacting play, although specific details were not provided. The betting market reflected the Bills' status as favorites, with odds indicating a strong likelihood of their victory.

In terms of previous meetings, the historical context was not detailed in the block, but the current season's performances suggested a clear disparity between the two teams. The Bills' ability to score, particularly in the first half, set the tone for the game, as they quickly established a lead that the Panthers could not overcome.

Viewers should have noted the Bills' offensive strategy, which effectively exploited the Panthers' defensive weaknesses, particularly in the secondary. The Panthers' inability to score touchdowns and their struggles in the red zone were critical factors that contributed to the final outcome. The game highlighted the Bills' potential as a playoff contender, while the Panthers were left to reassess their strategies moving forward.

Injury report

  • Jonathon BrooksQuestionableGeneral SorenessCarolina Panthers
  • Brady ChristensenInjured ReserveHamstringCarolina Panthers
  • Chuba HubbardQuestionableHamstringCarolina Panthers
  • Ryan HayesInjured ReserveUndisclosedCarolina Panthers
  • Bam Martin-ScottInjured ReserveHamstringCarolina Panthers
  • Khalil ShakirQuestionableUndisclosedBuffalo Bills
  • Keon ColemanQuestionableFootBuffalo Bills
  • Ty JohnsonQuestionableLower LegBuffalo Bills
  • Zane DurantInjured ReserveUndisclosedBuffalo Bills
  • Tyrell ShaversOutKnee - ACLBuffalo Bills

Leaders

  • Passing yardsAndy Dalton16/24, 175 YDS, 1 INTCarolina Panthers
  • Rushing yardsRico Dowdle8 CAR, 54 YDSCarolina Panthers
  • Receiving yardsTetairoa McMillan7 REC, 99 YDSCarolina Panthers
  • Passing yardsJosh Allen12/19, 163 YDS, 1 TDBuffalo Bills
  • Rushing yardsJames Cook III19 CAR, 216 YDS, 2 TDBuffalo Bills
  • Receiving yardsKhalil Shakir6 REC, 88 YDS, 1 TDBuffalo Bills

Recent form

Carolina Panthers

Last 10: 6-4Streak W323.9 scored · 26.8 allowed per game4-0 at home

  • W13-6at New York JetsOct 19
  • W30-27vs Dallas CowboysOct 12
  • W27-24vs Miami DolphinsOct 5
  • L13-42at New England PatriotsSep 28
  • W30-0vs Atlanta FalconsSep 21
  • L22-27at Arizona CardinalsSep 14
  • L10-26at Jacksonville JaguarsSep 7
  • W44-38at Atlanta FalconsJan 5
  • L14-48at Tampa Bay BuccaneersDec 29
  • W36-30vs Arizona CardinalsDec 22

Buffalo Bills

Last 10: 7-3Streak L229.5 scored · 23.7 allowed per game2-2 away

  • L14-24at Atlanta FalconsOct 13
  • L20-23vs New England PatriotsOct 6
  • W31-19vs New Orleans SaintsSep 28
  • W31-21vs Miami DolphinsSep 19
  • W30-10at New York JetsSep 14
  • W41-40vs Baltimore RavensSep 8
  • L16-23at New England PatriotsJan 5
  • W40-14vs New York JetsDec 29
  • W24-21vs New England PatriotsDec 22
  • W48-42at Detroit LionsDec 15

Standings

TeamLostPoints againstPoints forTiedWin %WonOverall
Buffalo0488801.00033-0
New England171501.50011-1-1
New York247390.33311-2
Miami363220.00000-3
Carolina189970.75033-1
Tampa Bay150400.66722-1
Atlanta145580.66722-1
New Orleans282470.33311-2

Box score

StatBuffalo BillsCarolina Panthers
First downs2319
First downs passing1011
First downs rushing125
First downs by penalty13
Third downs7-124-11
Fourth downs0-01-1
Offensive plays6059
Total yards410244
Yards per play6.84.1
Drives1011
Net passing yards165130
Completions14/2316/24
Yards per pass6.64.2
Interceptions thrown01
Sacks allowed2-207-45
Rushing yards245114
Rushing attempts3528
Yards per rush7.04.1
Red zone trips2-31-2
Penalties7-604-20
Turnovers03
Fumbles lost02
Defensive touchdowns00
Time of possession33:3226:28

Win probability

Above the line favours Carolina Panthers, below favours Buffalo Bills.

Venue

  • Bank of America StadiumCharlotte, NC
  • Attendance73505
  • OfficialsFrank Steratore, Craig Wrolstad, Rich Martinez, Danny Short, Brandon Cruse, Jeff Shears, Brett Bergman

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Fixture data from the league feeds. The report was written from the recorded facts for this game and nothing else.