Miami Dolphins vs Indianapolis Colts prediction & odds

The upcoming matchup between the Indianapolis Colts and the Miami Dolphins at Lucas Oil Stadium on November 15, 2026, presents a clash of two teams struggling to find their footing this season. This game is particularly interesting as it features two franchises looking to break out of lengthy losing streaks, with the Colts on a five-game losing streak and the Dolphins having lost their last two games.

In their last five games, the Colts have faced a tough schedule, suffering losses to the Pittsburgh Steelers (34-22), Tennessee Titans (26-20), Minnesota Vikings (16-10), Jacksonville Jaguars (42-7), and Dallas Cowboys (27-23). During this stretch, they have averaged 16.4 points scored per game while allowing 29.0 points.

The Dolphins, meanwhile, have experienced a similar fate. Their recent games include losses to the Minnesota Vikings (15-10), Cincinnati Bengals (31-24), a narrow victory over the New York Jets (28-25), and losses to the New England Patriots (24-19) and Detroit Lions (19-9). In their last five outings, they have averaged 18.0 points scored and allowed 22.8 points per game. Their away record mirrors their struggles, with a 1-4 mark and an average of 15.6 points scored while allowing 25.5 points.

Historically, the Colts have had the upper hand in their previous meeting against the Dolphins, winning decisively 33-8 on September 7, 2025. This recent success could provide a psychological advantage for the Colts as they prepare to face Miami again.

In terms of injuries, both teams are dealing with significant player absences. The Colts will be without Akeem Davis-Gaither (knee), Mo Alie-Cox (groin), Will Mallory (hamstring), Jalen Travis (knee), and Jaylon Carlies (neck), all of whom are either on injured reserve or out for the game. The Dolphins will also be missing several key players, including Darrell Baker Jr. (knee), Aaron Brewer (concussion), and Jared Wayne (quadriceps), while Chris Bell (knee) is listed as doubtful. Additionally, Malik Willis is on injured reserve for Miami.

The betting lines from DraftKings indicate that the Colts are favored by 4.5 points, with a total set at 37.5. The Colts' moneyline is -218, while the Dolphins sit at +180. This reflects the market's view of the Colts as the stronger team, despite their struggles this season.

Weather conditions for the game are expected to be cool, with a temperature of 46°F and wind gusts up to 10 mph, which could impact the passing game for both teams.

Fans tuning into this matchup should watch for the performance of Colts quarterback Daniel Jones, who has thrown for 1,722 yards with 6 touchdowns and 10 interceptions this season. Additionally, Jonathan Taylor leads the Colts in rushing with 656 yards and 8 touchdowns. For the Dolphins, Malik Willis has been the starting quarterback, accumulating 1,396 passing yards with 6 touchdowns and 6 interceptions before being placed on injured reserve. Ollie Gordon II leads Miami in rushing with 463 yards and 4 touchdowns.

As both teams seek to turn their seasons around, this matchup promises to be a critical moment for the Colts and Dolphins, who are desperate for a win to regain some momentum.