Los Angeles Rams vs Arizona Cardinals prediction & odds

The Arizona Cardinals will face the Los Angeles Rams at State Farm Stadium on November 15, 2026, in a matchup that promises to be compelling given their recent encounters. The Rams currently hold a 2-1 edge in their last three meetings, including a narrow defeat to the Cardinals earlier this season, where Arizona triumphed 18-16 on October 18. This fixture not only showcases a rivalry but also highlights contrasting fortunes as both teams vie for playoff positioning in the NFL.

Over their last five games, Arizona has recorded two wins and three losses, scoring an average of 18.2 points while allowing 27.6 points per game. Their recent form has seen them average just 19.8 points scored at home, which is concerning given the Rams' defensive capabilities.

Their last five games have yielded three wins and two losses, with an average of 25.8 points scored and 19.6 points allowed. The Rams have shown a stronger offensive output on the road, which could be pivotal in this matchup.

In terms of injuries, the Cardinals are dealing with several key players potentially missing the game. Hunter Long and Jayden Williams are both listed as questionable due to knee injuries, while Zachary Carter is on injured reserve with a knee issue. Additionally, Jon Gaines II and Hjalte Froholdt are out with an ankle and concussion, respectively. For the Rams, Steve Avila is out with a hamstring injury, and Trent McDuffie, Kam Curl, Davis Allen, and Myles Garrett are all questionable, which could impact their defensive strategy.

The betting market reflects the Rams as significant favorites, with DraftKings setting the spread at 9.5 points in favor of Los Angeles. The total for the game is set at 38.5 points, indicating expectations for a relatively low-scoring affair. The conditions for the game are expected to be favorable, with a temperature of 76°F and no precipitation, alongside light winds at 6 mph.

Viewers should watch for the performance of both quarterbacks, with Gardner Minshew II leading the Cardinals and Matthew Stafford at the helm for the Rams. Minshew has been effective in the passing game, while Stafford has a solid season with 2,374 passing yards and a notable touchdown-to-interception ratio. The effectiveness of the Rams' defense, particularly if they can capitalize on the Cardinals' injuries, will also be a focal point in this matchup.