San Francisco 49ers vs Dallas Cowboys prediction & odds

This game, scheduled for November 15, 2026, at 21:25 UTC, will see the Cowboys looking to leverage their home advantage against a formidable opponent.

The Cowboys have had a mixed bag in their last five games, recording two wins and three losses. Their most recent performance saw them secure a victory against the Indianapolis Colts with a score of 27-23 on November 8, 2026. Prior to that, they suffered losses to the Tampa Bay Buccaneers (24-16), Green Bay Packers (23-13), and Arizona Cardinals (33-30 in overtime). However, they did manage a significant win against the Philadelphia Eagles, where they triumphed 38-21. On average, the Cowboys have scored 24.8 points while allowing the same number in their last five outings.

In contrast, the 49ers have been on a roll, winning four of their last five games, including a decisive 38-17 victory over the Las Vegas Raiders on November 8, 2026. Their only recent setback came against the Atlanta Falcons, where they lost 29-20. Overall, the 49ers have averaged 27.4 points scored and allowed 21.2 points in their last five games. This performance underscores their offensive capabilities, led by quarterback Brock Purdy, who has thrown for 1,980 yards, 17 touchdowns, and 5 interceptions this season.

When it comes to home versus away performance, the Cowboys have a home record of 1-3 this season, while their away record stands at 3-3. The 49ers, on the other hand, boast a strong home record of 6-1 and an away record of 2-1, showcasing their ability to perform consistently regardless of the venue.

In terms of injuries, the Cowboys are dealing with several key players on the injury report. Jonathan Bullard is listed as questionable due to a calf injury, while Tyler Goodson is on injured reserve with a knee injury (ACL and MCL). Donovan Ezeiruaku is out with an ankle injury, and both Joey Porter Jr. and DaRon Bland are questionable, also dealing with ankle issues. The 49ers have their own injury concerns, with C.J. West, Nate Hobbs, and Gracen Halton all on injured reserve. Trent Williams and Renardo Green are both listed as questionable, with shoulder and back injuries, respectively.

The betting market, as provided by DraftKings, has placed the 49ers as 3.5-point favorites for this matchup, with a total set at 55.5 points. The odds indicate a competitive game, with the home money line for the Cowboys at 170.0 and the away money line for the 49ers at -205.

Weather conditions for the game are expected to be cool, with a temperature around 48°F, a 47% chance of precipitation, and wind gusts reaching 18 mph. These conditions could play a role in the game, potentially affecting passing and kicking strategies.

Fans watching this game should pay close attention to the performances of key players such as Dak Prescott for the Cowboys, who has thrown for 2,381 yards, 16 touchdowns, and 5 interceptions this season, and Christian McCaffrey for the 49ers, who has rushed for 457 yards and 9 touchdowns. The effectiveness of the Cowboys' defense against the 49ers' dynamic offense will also be a critical factor in determining the outcome of this matchup.